Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation. | Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation. Pei W, Yin W, Yu T, Zhang X, Zhang Q, Yang X, Shi C, Shen W, Liu G. | 10/3/2024 |
PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum. | PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum. Tanaka M, Takeshita K, Kunita A, Hasegawa K, Ushiku T. | 08/5/2024 |
Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms. | Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms. Itoh T, Omori Y, Seino M, Hirose K, Date F, Ono Y, Mizukami Y, Aoki S, Ishida M, Mizuma M, Morikawa T, Higuchi R, Honda G, Okamura Y, Kinoshita K, Unno M, Furukawa T. | 01/26/2024 |
Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems. | Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems. Maimaitiaili Y, Fukumura Y, Hirabayashi K, Kinowaki Y, Naito Y, Saito A, Rong L, Nakahodo J, Yao T. | 01/11/2023 |
Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC. | Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC. Huang Y, Feng L, Bao Y, Zhang Y, Liang J, Mao Q, Li J, Jiang C., Free PMC Article | 05/7/2022 |
Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene. | Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene. Khamse S, Jafarian Z, Bozorgmehr A, Tavakoli M, Afshar H, Keshavarz M, Moayedi R, Ohadi M., Free PMC Article | 02/12/2022 |
The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF. | The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF. Jessulat M, Amin S, Hooshyar M, Malty R, Moutaoufik MT, Zilocchi M, Istace Z, Phanse S, Aoki H, Omidi K, Burnside D, Samanfar B, Aly KA, Golshani A, Babu M., Free PMC Article | 10/9/2021 |
PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A. | PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A. Espiard S, Drougat L, Settas N, Haydar S, Bathon K, London E, Levy I, Faucz FR, Calebiro D, Bertherat J, Li D, Levine MA, Stratakis CA., Free PMC Article | 10/2/2021 |
Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. | Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, Hildebrand MS, Coleman M, Bahlo M, Bennett MF, Schneider AL, Scheffer IE, Kibæk M, Kristiansen BS, Issa MY, Mehrez MI, Ismail S, Tenorio J, Li G, Skålhegg BS, Otaify GA, Temtamy S, Aglan M, Jønch AE, De Luca A, Mortier G, Cormier-Daire V, Ziegler A, Wallis M, Lapunzina P, Herberg FW, Taylor SS, Ruiz-Perez VL., Free PMC Article | 12/12/2020 |
MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB. | MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB. Wang Y, Wang B, Zhou H, Zhang X, Qian X, Cui J., Free PMC Article | 09/26/2020 |
We identified fusions in PRKACA and PRKACB genes in pancreatic and biliary IOPNs, as well as in PDACs and pancreatic cyst fluid and bile duct cells from the same patients. These fusions might be used to identify patients at risk for IOPNs and their associated invasive carcinomas. | Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct. Singhi AD, Wood LD, Parks E, Torbenson MS, Felsenstein M, Hruban RH, Nikiforova MN, Wald AI, Kaya C, Nikiforov YE, Favazza L, He J, McGrath K, Fasanella KE, Brand RE, Lennon AM, Furlan A, Dasyam AK, Zureikat AH, Zeh HJ, Lee K, Bartlett DL, Slivka A., Free PMC Article | 04/11/2020 |
Cbeta2 subunit of protein kinase A mRNA was up-regulated in prostate cancer and low expression of Cbeta2 mRNA in prostate cancer biopsies correlated with poor survival. | Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness. Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS. | 03/3/2018 |
analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 | Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi. Susuki-Miyata S, Miyata M, Lee BC, Xu H, Kai H, Yan C, Li JD., Free PMC Article | 07/4/2015 |
The gene polymorphism loci rs12132032 in PRKACB maybe a potential risk factor for anencephaly in Chinese population from Shanxi, while gender susceptibility may influence the correlation. | Association between PKA gene polymorphism and NTDs in high risk Chinese population in Shanxi. Wu J, Lu X, Wang Z, Shangguan S, Chang S, Li R, Wu L, Bao Y, Niu B, Wang L, Zhang T., Free PMC Article | 08/9/2014 |
The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified. | Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Erlbruch A, Hung CW, Seidler J, Borrmann K, Gesellchen F, König N, Kübler D, Herberg FW, Lehmann WD, Bossemeyer D. | 12/4/2010 |
activated by podophyllotoxin | Podophyllotoxin induces CREB phosphorylation and CRE-driven gene expression via PKA but not MAPKs. Chen YQ, Xie X. | 09/20/2010 |
Observational study and genome-wide association study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity. Liu YJ, Guo YF, Zhang LS, Pei YF, Yu N, Yu P, Papasian CJ, Deng HW., Free PMC Article | 06/30/2010 |
PGE(2)-induced CYP1B1 expression is mediated by ligand-independent activation of the ERalpha pathway as a result of the activation of ERK, Akt, and PKA in breast cancer cells. | Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. Han EH, Kim HG, Hwang YP, Song GY, Jeong HG. | 06/28/2010 |
Data show that PI3K activation and PIP3 production lead to recruitment of the PKB/beta-arrestin/PDE4 complex to the membrane via the PKB PH domain, resulting in degradation of the TCR-induced cAMP pool and allowing full T-cell activation to proceed. | Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. Bjørgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, Okkenhaug K, Houslay MD, Taskén K., Free PMC Article | 04/12/2010 |
Data show that Phosphorylation of The(197) in the activation loop on protein kinase A decreased the K(m) by approximately 15- and 7-fold for kemptide and ATP, respectively. | Global consequences of activation loop phosphorylation on protein kinase A. Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL Jr, Taylor SS., Free PMC Article | 04/12/2010 |
Results suggest that PKA can negatively regulate ERalpha, at least in part, through FoxH1. | PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity. Yum J, Jeong HM, Kim S, Seo JW, Han Y, Lee KY, Yeo CY. | 01/21/2010 |
Report expression of protein kinase A and C subunits in post-mortem prefrontal cortex from persons with major depression and normal controls. | Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls. Shelton RC, Hal Manier D, Lewis DA., Free PMC Article | 01/21/2010 |
Findings show that PKIB and PKA-C kinase can have critical functions of aggressive phenotype of PCs through Akt phosphorylation and that they should be a promising molecular target for PC treatment. | Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways. Chung S, Furihata M, Tamura K, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H. | 01/21/2010 |
In human primary pigmented nodular adrenocortical disease tissues, dexamethasone paradoxically stimulates cortisol release through a glucocorticoid receptor-mediated effect on PKA catalytic subunits. | The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits. Louiset E, Stratakis CA, Perraudin V, Griffin KJ, Libé R, Cabrol S, Fève B, Young J, Groussin L, Bertherat J, Lefebvre H., Free PMC Article | 01/21/2010 |
Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. | Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Fenne IS, Hoang T, Hauglid M, Sagen JV, Lien EA, Mellgren G. | 01/21/2010 |