| MITOFUSIN 1 AS A MARKER FOR EMBRYO QUALITY AND DEVELOPMENT IN RELEVANCE TO ICSI OUTCOME IN INFERTILE FEMALES. | MITOFUSIN 1 AS A MARKER FOR EMBRYO QUALITY AND DEVELOPMENT IN RELEVANCE TO ICSI OUTCOME IN INFERTILE FEMALES.
Khalil R, Mossa H, Jwad M. | 02/14/2024 |
| Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease. | Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease.
Kırmızıgül ÖA, Sabanci A, Dişli F, Yıldız S, Milward MR, Aral K. | 02/2/2024 |
| Mitofusin 1 overexpression rescues the abnormal mitochondrial dynamics caused by the Mitofusin 2 K357T mutation in vitro. | Mitofusin 1 overexpression rescues the abnormal mitochondrial dynamics caused by the Mitofusin 2 K357T mutation in vitro.
Stavropoulos F, Georgiou E, Schiza N, Bell S, Baloh RH, Kleopa KA, Sargiannidou I. | 09/8/2023 |
| LncRNA gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type II epithelial cells by positively regulating MFN1 in an in vitro model of hyperoxia-induced acute lung injury. | LncRNA gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type II epithelial cells by positively regulating MFN1 in an in vitro model of hyperoxia-induced acute lung injury.
Liu G, Yin C, Qian M, Xiao X, Wu H, Fu F., Free PMC Article | 06/1/2023 |
| Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus. | Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus.
Becker YLC, Gagné JP, Julien AS, Lévesque T, Allaeys I, Gougeard N, Rubio V, Boisvert FM, Jean D, Wagner E, Poirier GG, Fortin PR, Boilard É. | 07/2/2022 |
| Associations between OPA1, MFN1, and MFN2 polymorphisms and primary open angle glaucoma in Polish participants of European ancestry. | Associations between OPA1, MFN1, and MFN2 polymorphisms and primary open angle glaucoma in Polish participants of European ancestry.
Milanowski P, Kosior-Jarecka E, Łukasik U, Wróbel-Dudzińska D, Milanowska J, Khor CC, Aung T, Kocki J, Żarnowski T. | 04/30/2022 |
| Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca(2+) levels. | Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca(2+) levels.
Fatiga FF, Wang LJ, Hsu T, Capuno JI, Fu CY. | 03/19/2022 |
| The effect of gestational diabetes on the expression of mitochondrial fusion proteins in placental tissue. | The effect of gestational diabetes on the expression of mitochondrial fusion proteins in placental tissue.
Kolac UK, Kurek Eken M, Ünübol M, Donmez Yalcin G, Yalcin A. | 03/5/2022 |
| Analysis of mitochondrial regulatory transcripts in publicly available datasets with validation in placentae from pre-term, post-term and fetal growth restriction pregnancies. | Analysis of mitochondrial regulatory transcripts in publicly available datasets with validation in placentae from pre-term, post-term and fetal growth restriction pregnancies.
Bartho LA, O'Callaghan JL, Fisher JJ, Cuffe JSM, Kaitu'u-Lino TJ, Hannan NJ, Clifton VL, Perkins AV. | 02/26/2022 |
| Role of the lipid transport protein StarD7 in mitochondrial dynamics. | Role of the lipid transport protein StarD7 in mitochondrial dynamics.
Rojas ML, Cruz Del Puerto MM, Flores-Martín J, Racca AC, Kourdova LT, Miranda AL, Panzetta-Dutari GM, Genti-Raimondi S. | 01/8/2022 |
| Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy. | Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy.
Ning Y, Cai Y, Dai Y, Li F, Mo S, Werz O, Chen X., Free PMC Article | 11/27/2021 |
| Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy. | Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy.
Hsiao YT, Shimizu I, Wakasugi T, Yoshida Y, Ikegami R, Hayashi Y, Suda M, Katsuumi G, Nakao M, Ozawa T, Izumi D, Kashimura T, Ozaki K, Soga T, Minamino T., Free PMC Article | 10/30/2021 |
| Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway. | Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway.
Liu HJ, Qin Y, Zhao ZH, Zhang Y, Yang JH, Zhai DH, Cui F, Luo C, Lu MX, Liu PP, Xu HW, Li K, Sun B, Chen S, Zhou HG, Yang C, Sun T., Free PMC Article | 06/5/2021 |
| The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism. | The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism.
Tolosa-Díaz A, Almendro-Vedia VG, Natale P, López-Montero I., Free PMC Article | 02/13/2021 |
| Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth. | Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth.
Li M, Wang L, Wang Y, Zhang S, Zhou G, Lieshout R, Ma B, Liu J, Qu C, Verstegen MMA, Sprengers D, Kwekkeboom J, van der Laan LJW, Cao W, Peppelenbosch MP, Pan Q., Free PMC Article | 01/16/2021 |
| Our results reveal a critical involvement of mitochondrial dynamics in hepatocellular carcinoma (HCC) metastasis via modulating glucose metabolic reprogramming. MFN1 may serve as a novel potential therapeutic target for HCC | MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming.
Zhang Z, Li TE, Chen M, Xu D, Zhu Y, Hu BY, Lin ZF, Pan JJ, Wang X, Wu C, Zheng Y, Lu L, Jia HL, Gao S, Dong QZ, Qin LX., Free PMC Article | 07/18/2020 |
| This study elucidates an essential role of MFN1 in stem cell fate determination to mediate EMT-associated stemness. | Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin.
Wu MJ, Chen YS, Kim MR, Chang CC, Gampala S, Zhang Y, Wang Y, Chang CY, Yang JY, Chang CJ. | 06/6/2020 |
| Human Mfn1 contains internal N-Terminal mitochondrial targeting sequence (MTS) localized in the loop region between the two helices of the conserved transmembrane domain. Internal MTS is a shared feature of all opisthokont mitofusins. It facilitates anchoring and targeting of these proteins to the mitochondrial membrane. | Identification and characterization of signal peptide of Mitofusin1 (Mfn1).
Sinha S, Aradhyam GK. | 11/9/2019 |
| Structural basis for how MFN1 mediates homotypic membrane fusion. | Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion.
Yan L, Qi Y, Huang X, Yu C, Lan L, Guo X, Rao Z, Hu J, Lou Z. | 07/27/2019 |
| heptad repeat domain of Mitofusin proteins induces membrane fusion and possesses a conserved amphipathic helix that folds upon interaction with the lipid bilayer surface. | The heptad repeat domain 1 of Mitofusin has membrane destabilization function in mitochondrial fusion.
Daste F, Sauvanet C, Bavdek A, Baye J, Pierre F, Le Borgne R, David C, Rojo M, Fuchs P, Tareste D., Free PMC Article | 04/6/2019 |
| The mRNA upregulation of Mitofusin 1 and 2 provides first insight into the complex changes of mitochondrial dynamics in cardiomyocytes of patients with reversible heart failure due to tachycardiomyopathy. | Mitochondrial Dynamics in Tachycardiomyopathy.
Heinzmann D, Klingel K, Müller K, Kumbrink J, Kirchner T, Schreieck J, Gawaz M, Seizer P. | 03/23/2019 |
| The results lead to a revised understanding of Mfn 1 as single-spanning outer membrane proteins with an Nout-Cin orientation, providing functional insight into the IMS contribution to redox-regulated fusion events. | A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space.
Mattie S, Riemer J, Wideman JG, McBride HM., Free PMC Article | 12/22/2018 |
| The results may suggest that TP53BP1 and MFN1 frameshift mutations and their intratumoral heterogeneity (ITH) could contribute to cancer development by inhibiting the TSG activities. | Intratumoral heterogeneity for frameshift mutations of TP53BP1 and MFN1 genes in colorectal cancers.
Choi EJ, Kim MS, Yoo NJ, Lee SH. | 11/3/2018 |
| The results show that a metabolic shift from glycolysis in young to mitochondrial respiration in old normal human fibroblasts occurs during chronological lifespan, and MFN1 and OPA1 regulate this process. | Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging.
Son JM, Sarsour EH, Kakkerla Balaraju A, Fussell J, Kalen AL, Wagner BA, Buettner GR, Goswami PC., Free PMC Article | 05/19/2018 |
| mitochondria elongation under hypoxic condition is regulated through SIRT1-mediated MFN1 deacetylation and accumulation. | Mitochondria elongation is mediated through SIRT1-mediated MFN1 stabilization.
Oanh NTK, Park YY, Cho H. | 05/19/2018 |