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    DEPDC1 DEP domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 55635, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1alpha pathway.

    DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway.
    Di SC, Chen WJ, Yang W, Zhang XM, Dong KQ, Tian YJ, Sun Y, Qian C, Chen JX, Liu ZC, Gong ZX, Chu J, Zhou W, Pan XW, Cui XG., Free PMC Article

    09/3/2024
    Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.

    Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.
    Lv M, Li X, Yin Z, Yang H, Zhou B., Free PMC Article

    04/5/2024
    DEPDC1 as a crucial factor in the progression of human osteosarcoma.

    DEPDC1 as a crucial factor in the progression of human osteosarcoma.
    Shen L, Li H, Liu R, Zhou C, Bretches M, Gong X, Lu L, Zhang Y, Zhao K, Ning B, Yang SY, Zhang A., Free PMC Article

    03/24/2023
    DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway.

    DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway.
    Yang M, Zhang H, Gao S, Huang W., Free PMC Article

    03/6/2023
    Glycolysis-Related Gene Analyses Indicate That DEPDC1 Promotes the Malignant Progression of Oral Squamous Cell Carcinoma via the WNT/beta-Catenin Signaling Pathway.

    Glycolysis-Related Gene Analyses Indicate That DEPDC1 Promotes the Malignant Progression of Oral Squamous Cell Carcinoma via the WNT/β-Catenin Signaling Pathway.
    Huang G, Chen S, Washio J, Paka Lubamba G, Takahashi N, Li C., Free PMC Article

    03/1/2023
    Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1.

    Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1.
    Sharen G, Li X, Sun J, Zhang L, Xi W, Zhao X, Han F, Jia L, A R, Cheng H, Hou M., Free PMC Article

    11/5/2022
    FOXO3amodulated DEPDC1 promotes malignant progression of nephroblastoma via the Wnt/betacatenin signaling pathway.

    FOXO3a‑modulated DEPDC1 promotes malignant progression of nephroblastoma via the Wnt/β‑catenin signaling pathway.
    Geng G, Li Q, Guo X, Ni Q, Xu Y, Ma Z, Wang Y, Ming M., Free PMC Article

    07/23/2022
    Long non-coding RNA DEPDC1-AS1 promotes proliferation and migration of human gastric cancer cells HGC-27 via the human antigen R-F11R pathway.

    Long non-coding RNA DEPDC1-AS1 promotes proliferation and migration of human gastric cancer cells HGC-27 via the human antigen R-F11R pathway.
    Xu W, Wang J, Xu J, Li S, Zhang R, Shen C, Xie M, Zheng B, Gu M., Free PMC Article

    04/30/2022
    Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression.

    Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression.
    Tian C, Abudoureyimu M, Lin X, Chu X, Wang R., Free PMC Article

    02/5/2022
    [DEPDC1 is Highly Expressed in Lung Adenocarcinoma and Promotes Tumor Cell Proliferation].

    [DEPDC1 is Highly Expressed in Lung Adenocarcinoma and Promotes Tumor Cell Proliferation].
    Shen J, Xi M., Free PMC Article

    01/29/2022
    Long noncoding RNA KTN1 antisense RNA 1exerts an oncogenic function in lung adenocarcinoma by regulating DEP domain containing 1 expression via activating epithelial-mesenchymal transition.

    Long noncoding RNA KTN1 antisense RNA 1exerts an oncogenic function in lung adenocarcinoma by regulating DEP domain containing 1 expression via activating epithelial-mesenchymal transition.
    Li YY, Li W, Chang GZ, Li YM.

    10/30/2021
    Overexpression of gene DEP domain containing 1 and its clinical prognostic significance in colorectal cancer.

    Overexpression of gene DEP domain containing 1 and its clinical prognostic significance in colorectal cancer.
    Shen X, Han J., Free PMC Article

    10/30/2021
    DEPDC1 upregulation promotes cell proliferation and predicts poor prognosis in patients with gastric cancer.

    DEPDC1 upregulation promotes cell proliferation and predicts poor prognosis in patients with gastric cancer.
    Gong Z, Chu H, Chen J, Jiang L, Gong B, Zhu P, Zhang C, Wang Z, Zhang W, Wang J, Li C, Zhao H.

    10/9/2021
    DEP Domain Containing 1 Promotes Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Enhancing Expression of Suppressor of Zest 12.

    DEP Domain Containing 1 Promotes Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Enhancing Expression of Suppressor of Zest 12.
    Wang Q, Jiang S, Liu J, Ma G, Zheng J, Zhang Y.

    10/9/2021
    ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A.

    ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A.
    Wang Y, Wu J, Luo W, Zhang H, Shi G, Shen Y, Zhu Y, Ma C, Dai B, Ye D, Zhu Y., Free PMC Article

    09/25/2021
    DEPDC1 up-regulates RAS expression to inhibit autophagy in lung adenocarcinoma cells.

    DEPDC1 up-regulates RAS expression to inhibit autophagy in lung adenocarcinoma cells.
    Wang W, Li A, Han X, Wang Q, Guo J, Wu Y, Wang C, Huang G., Free PMC Article

    06/26/2021
    MicroRNA-374c-5p inhibits the development of breast cancer through TATA-box binding protein associated factor 7-mediated transcriptional regulation of DEP domain containing 1.

    MicroRNA-374c-5p inhibits the development of breast cancer through TATA-box binding protein associated factor 7-mediated transcriptional regulation of DEP domain containing 1.
    Hao S, Tian W, Chen Y, Wang L, Jiang Y, Gao B, Luo D., Free PMC Article

    09/5/2020
    High DEPDC1 expression is associated with hepatocellular carcinoma cell proliferation, invasion and angiogenesis.

    DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.
    Guo W, Li H, Liu H, Ma X, Yang S, Wang Z., Free PMC Article

    01/25/2020
    DEPDC1, negatively regulated by miR-26b, promotes cell proliferation and tumor growth via up-regulating FOXM1 expression, implying an important underlying mechanism of regulating the progression of triple negative breast cancer.

    DEPDC1, negatively regulated by miR-26b, facilitates cell proliferation via the up-regulation of FOXM1 expression in TNBC.
    Zhang L, Du Y, Xu S, Jiang Y, Yuan C, Zhou L, Ma X, Bai Y, Lu J, Ma J.

    11/2/2019
    High expression of DEPDC1 in tumor tissue appears to be associated with tumor progression and poor prognosis

    Prognostic Value of DEPDC1 Expression in Tumor and Non-tumor Tissue of Patients With Hepatocellular Carcinoma.
    Amisaki M, Yagyu T, Uchinaka EI, Morimoto M, Hanaki T, Watanabe J, Tokuyasu N, Sakamoto T, Honjo S, Fujiwara Y.

    08/10/2019
    Differential DEP domain containing 1 (DEPDC1) expression level shows diagnostic and prognostic significance in liver hepatocellular carcinoma (LIHC) samples.

    DEP domain containing 1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis.
    Qu D, Cui F, Lu D, Yang Y, Xu Y., Free PMC Article

    01/19/2019
    Our results demonstrated that increased expression of SDP35/DEPDC1A and XPT1/DEPDC1B correlates with metastatic progression of metastatic soft tissue sarcoma

    Prognostic role of XTP1/DEPDC1B and SDP35/DEPDC1A in high grade soft-tissue sarcomas.
    Pollino S, Benassi MS, Pazzaglia L, Conti A, Bertani N, Righi A, Piccinni-Leopardi M, Picci P, Perris R.

    10/6/2018
    The results of this study suggest that DEPDC1 represents a target molecule for the treatment of glioma.

    Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells.
    Kikuchi R, Sampetrean O, Saya H, Yoshida K, Toda M.

    04/21/2018
    DEPDC1a, but not DEPDC1b, was required for the integrity of centrosome and organization of the bipolar spindle

    Phosphorylation of DEPDC1 at Ser110 is required to maintain centrosome organization during mitosis.
    Chen D, Ito S, Hyodo T, Asano-Inami E, Yuan H, Senga T.

    10/21/2017
    DEPDC1 mRNA and protein expression levels were dramatically increased in prostate cancer tissues and cell lines. Overexpression of DEPDC1 promoted, but depletion of DEPDC1 inhibited cell proliferation by regulating the G1-S phase cell cycle transition.

    DEPDC1 promotes cell proliferation and tumor growth via activation of E2F signaling in prostate cancer.
    Huang L, Chen K, Cai ZP, Chen FC, Shen HY, Zhao WH, Yang SJ, Chen XB, Tang GX, Lin X.

    08/12/2017
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