| MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma. | MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma.
Meng L, Gao J, Mo W, Wang B, Shen H, Cao W, Ding M, Diao W, Chen W, Zhang Q, Shu J, Dai H, Guo H., Free PMC Article | 12/20/2023 |
| Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome. | Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome.
Zhou W, Yu C, Long Y., Free PMC Article | 05/31/2023 |
| Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA. | Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA.
Zhang Y, Luo M, Cui X, O'Connell D, Yang Y., Free PMC Article | 09/17/2022 |
| Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes. | Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
Sharma I, Deng F, Liao Y, Kanwar YS., Free PMC Article | 10/24/2020 |
| MIOX-induced oxidant stress and tunicamycin-induced endoplasmic reticulum stress are interlinked, and both of the events may feed into each other to amplify the tubulointerstitial injury. | Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.
Tominaga T, Sharma I, Fujita Y, Doi T, Wallner AK, Kanwar YS., Free PMC Article | 11/30/2019 |
| increased MIOX expression in the kidney contributes to tubular damage in DN (Diabetic Nephropathy). The concentration of MIOX in the serum and urine may serve as a new biomarker for the early diagnosis of DN. | The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy.
Gao P, Xu B, Song P, Zhu X, Yuan S, Kanwar YS, Sun L. | 03/2/2019 |
| Our results suggest that serum MIOX levels do not change in polycystic ovary syndrome. It was, therefore, concluded that myoinositol deficiency observed in PCOS was not related to the level of MIOX enzyme which cleaves myoinositol. | Does myo-inositol oxygenase, the only enzyme to catalyze myo-inositol in vivo, play a role in the etiology of polycystic ovarian syndrome?
Mertoglu C, Gunay M, Gul V, Kulhan M, Aktas M, Coban TA. | 09/22/2018 |
| these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy. | High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
Sharma I, Dutta RK, Singh NK, Kanwar YS., Free PMC Article | 05/27/2017 |
| Data suggest that MIOX expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of MIOX activity is related to phosphorylation of serine/threonine residues. | Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
Tominaga T, Dutta RK, Joladarashi D, Doi T, Reddy JK, Kanwar YS., Free PMC Article | 06/4/2016 |
| results demonstrated that the polymorphism (rs761745) in the promoter region of myo-inositol oxygenase(MIOX) gene may be associated with the development of type 1 diabetes mellitus in our studied population | Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.
Yang B, Hodgkinson A, Millward BA, Demaine AG, Yang B, Hodgkinson A, Millward BA, Demaine AG. | 02/5/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.
Yang B, Hodgkinson A, Millward BA, Demaine AG, Yang B, Hodgkinson A, Millward BA, Demaine AG. | 12/2/2009 |
| Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa protein. | Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney.
Arner RJ, Prabhu KS, Reddy CC. | 01/21/2010 |
| expression of MIOX is up-regulated by a positive feedback mechanism where xylitol, one of the products of MI catabolism via the glucuronate-xylulose pathway, induces an overexpression of MIOX | Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells.
Prabhu KS, Arner RJ, Vunta H, Reddy CC. | 01/21/2010 |
| myo-inositol oxygenase (MIOX) | myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol.
Arner RJ, Prabhu KS, Thompson JT, Hildenbrandt GR, Liken AD, Reddy CC., Free PMC Article | 02/19/2002 |