| IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer. | IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer.
Yuan SF, Su CW, Chan LP, Nguyen HDH, Chen YK, Du JK, Cheng KH, Wang YY. | 09/24/2024 |
| Transcription-coupled DNA-protein crosslink repair by CSB and CRL4[CSA]-mediated degradation. | Transcription-coupled DNA-protein crosslink repair by CSB and CRL4(CSA)-mediated degradation.
van Sluis M, Yu Q, van der Woude M, Gonzalo-Hansen C, Dealy SC, Janssens RC, Somsen HB, Ramadhin AR, Dekkers DHW, Wienecke HL, Demmers JJPG, Raams A, Davó-Martínez C, Llerena Schiffmacher DA, van Toorn M, Häckes D, Thijssen KL, Zhou D, Lammers JG, Pines A, Vermeulen W, Pothof J, Demmers JAA, van den Berg DLC, Lans H, Marteijn JA., Free PMC Article | 08/14/2024 |
| Endometrial senescence is mediated by interleukin 17 receptor B signaling. | Endometrial senescence is mediated by interleukin 17 receptor B signaling.
Kawamura K, Matsumura Y, Kawamura T, Araki H, Hamada N, Kuramoto K, Yagi H, Onoyama I, Asanoma K, Kato K., Free PMC Article | 07/17/2024 |
| CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1. | CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1.
Deng J, Zhang T, Liu F, Han Q, Li Q, Guo X, Ma Y, Li L, Shao G. | 05/28/2022 |
| IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE. | IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE.
Liu S, Sun Y, Tang Y, Hu R, Zhou Q, Li X. | 12/4/2021 |
| MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival. | MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.
Bacher S, Stekman H, Farah CM, Karger A, Kracht M, Schmitz ML., Free PMC Article | 10/16/2021 |
| IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination. | IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination.
Bie Q, Song H, Chen X, Yang X, Shi S, Zhang L, Zhao R, Wei L, Zhang B, Xiong H, Zhang B., Free PMC Article | 10/16/2021 |
| Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses. | Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.
Bing N, Zhou H, Chen X, Hirose T, Kochi Y, Tsuchida Y, Ishigaki K, Sumitomo S, Fujio K, Zhang B, Valdez H, Vincent MS, Martin D, Clark JD., Free PMC Article | 08/14/2021 |
| An IMiD-induced SALL4 degron system for selective degradation of target proteins. | An IMiD-induced SALL4 degron system for selective degradation of target proteins.
Yamanaka S, Shoya Y, Matsuoka S, Nishida-Fukuda H, Shibata N, Sawasaki T., Free PMC Article | 06/26/2021 |
| CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. | CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.
Lidak T, Baloghova N, Korinek V, Sedlacek R, Balounova J, Kasparek P, Cermak L., Free PMC Article | 06/19/2021 |
| IL17RB predicts the prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer. | IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer.
Song Y, Ji B, Jiang CX, Chen ZM, Yao NH, Mukaida N, Huang H. | 05/2/2020 |
| Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. | Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
Liu H, Lu W, He H, Wu J, Zhang C, Gong H, Yang C. | 04/18/2020 |
| Using CRISPR-Cas9-mediated IL17RB-CreERT2 knockin human organoids, study showed that IL17RB marks human colorectal cancer stem cells by lineage tracing, and that long-term targeting of IL17RB+ cells strongly suppressed the tumor growth in vivo. This study identifies IL17RB+ cancer stem cells and preclinically validates them as a cancer therapeutic target. | Lineage tracing and targeting of IL17RB(+) tuft cell-like human colorectal cancer stem cells.
Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H., Free PMC Article | 04/11/2020 |
| As the ligase activity of CRL4Cdt2 depends on proliferating cell nuclear antigen (PCNA) loading onto DNA, the present results suggest that the DNA-binding domain facilitates the CRL4Cdt2-mediated recognition and ubiquitination of substrates bound to PCNA on chromatin. | A DNA-binding domain in the C-terminal region of Cdt2 enhances the DNA synthesis-coupled CRL4Cdt2 ubiquitin ligase activity for Cdt1.
Mazian MA, Suenaga N, Ishii T, Hayashi A, Shiomi Y, Nishitani H. | 08/3/2019 |
| IL-17RB was up-regulated in lung cancer tissue and associated with lymph node metastasis and distant metastasis, as well as poor patient survival. 17RB activation is required for IL-17B-mediated ERK phosphorylation. | A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis.
Yang YF, Lee YC, Lo S, Chung YN, Hsieh YC, Chiu WC, Yuan SF. | 05/18/2019 |
| The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients. | Detection of gene expression in sentinel lymph node of primary breast cancer patients.
Soleimani S, Alizadeh Shargh S, Keramatinia A, Mehrvar N, Mansouri N, Doosti A, Mortazavi-Tabatabaei SA, Hashemi M, Movafagh A. | 09/22/2018 |
| The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells. | Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.
Bie Q, Sun C, Gong A, Li C, Su Z, Zheng D, Ji X, Wu Y, Guo Q, Wang S, Xu H., Free PMC Article | 02/17/2018 |
| IL-17RB can enhance thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression, suggesting that IL-17RB may act as a potential therapeutic target for thyroid cancer therapy. | IL-17RB enhances thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression.
Ren L, Xu Y, Liu C, Wang S, Qin G. | 11/11/2017 |
| IL-4 signaling up-regulates the IL-25 axis in human monocytic cells, and IL-25 may provide autocrine signals in monocytes and macrophages to sustain IL-17Rb expression and predispose to alternative activation. | IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling.
Weathington NM, Kanth SM, Gong Q, Londino J, Hoji A, Rojas M, Trudeau J, Wenzel S, Mallampalli RK., Free PMC Article | 09/23/2017 |
| Our results identify a biochemical role for WDTC1 and extend the functional range of the CRL4 complex to the suppression of fat accumulation. | The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.
Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y., Free PMC Article | 08/19/2017 |
| Atopic IL-17RB(+) DCs can be up-regulated by LPS and promote a TH2-type response, implying that the IL-25/IL-17RB pathway may represent a potential molecular mechanism underlying the regulation of ECs on DCs in allergic airway disease. | The T(H)2-polarizing function of atopic interleukin 17 receptor B-positive dendritic cells up-regulated by lipopolysaccharide.
Zheng R, Chen FH, Gao WX, Wang D, Yang QT, Wang K, Lai YY, Deng J, Jiang LJ, Sun YQ, Shi JB. | 08/5/2017 |
| IL-17RB(+) granulocytes and T2M cells from peripheral blood were increased in subjects with asthma, and the 2 cell types correlated with degree of airflow obstruction. | IL-17RB(+) granulocytes are associated with airflow obstruction in asthma.
Li L, Lukacs NW, Schaller MA, Petersen B, Baptist AP., Free PMC Article | 07/29/2017 |
| collectively, this study uncovers a new role for CRL4CDT2 in protecting genomic integrity against replication stress via regulated proteolysis of PCNA-associated SDE2 and provides insights into how an integrated UBL domain within linear polypeptide sequence controls protein stability and function. | PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress.
Jo U, Cai W, Wang J, Kwon Y, D'Andrea AD, Kim H., Free PMC Article | 05/13/2017 |
| This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW} | The role of IL17B-IL17RB signaling pathway in breast cancer.
Alinejad V, Dolati S, Motallebnezhad M, Yousefi M. | 03/18/2017 |
| The Breast Cancer Index (BCI) is a continuous risk index model of two previously described biomarkers: molecular grade index (MGI) and HOXB13:IL17BR (H:I) ratio | Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study.
Sgroi DC, Chapman JA, Badovinac-Crnjevic T, Zarella E, Binns S, Zhang Y, Schnabel CA, Erlander MG, Pritchard KI, Han L, Shepherd LE, Goss PE, Pollak M., Free PMC Article | 10/8/2016 |