| miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum. | miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum.
| 02/28/2024 |
| Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration. | Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.
Chen F, Lei L, Chen S, Zhao Z, Huang Y, Jiang G, Guo X, Li Z, Zheng Z, Wang J., Free PMC Article | 01/9/2024 |
| SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas. | SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.
Tanaka I, Dayde D, Tai MC, Mori H, Solis LM, Tripathi SC, Fahrmann JF, Unver N, Parhy G, Jain R, Parra ER, Murakami Y, Aguilar-Bonavides C, Mino B, Celiktas M, Dhillon D, Casabar JP, Nakatochi M, Stingo F, Baladandayuthapani V, Wang H, Katayama H, Dennison JB, Lorenzi PL, Do KA, Fujimoto J, Behrens C, Ostrin EJ, Rodriguez-Canales J, Hase T, Fukui T, Kajino T, Kato S, Yatabe Y, Hosoda W, Kawaguchi K, Yokoi K, Chen-Yoshikawa TF, Hasegawa Y, Gazdar AF, Wistuba II, Hanash S, Taguchi A., Free PMC Article | 03/26/2022 |
| Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone. | Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.
He Y, Cheng D, Lian C, Liu Y, Luo W, Wang Y, Ma C, Wu Q, Tian P, He D, Jia Z, Lv X, Zhang X, Pan Z, Lu J, Xiao Y, Zhang P, Liang Y, Yang Q, Hu G., Free PMC Article | 02/5/2022 |
| Clinical Significance of Serglycin Expression in Human Breast Cancer Patients. | Clinical Significance of Serglycin Expression in Human Breast Cancer Patients.
Hosoya K, Nosaka K, Sakabe T, Wakahara M, Oshima Y, Suzuki Y, Nakamura H, Umekita Y. | 01/15/2022 |
| The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a beta-catenin-dependent manner. | The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.
Cao L, Luo FF, Huang HB, Huang TJ, Hu H, Zheng LS, Wang J, Peng LX, Qian CN, Huang BJ., Free PMC Article | 12/25/2021 |
| Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study. | Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study.
Li Y, Chen H, Lu H, Zou Z, Li Y. | 12/18/2021 |
| The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy. | The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy.
Wang L, Han Y, Wang X., Free PMC Article | 11/6/2021 |
| SRGN, a new identified shear-stress-responsive gene in endothelial cells. | SRGN, a new identified shear-stress-responsive gene in endothelial cells.
Ma Q, Gu W, Li T, Zhang K, Cui Y, Qu K, Wang N, Humphry R, Durkan C, Qiu J, Wang G. | 05/22/2021 |
| SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression. | SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression.
Zhang Z, Qiu N, Yin J, Zhang J, Liu H, Guo W, Liu M, Liu T, Chen D, Luo K, Li H, He Z, Liu J, Zheng G., Free PMC Article | 02/20/2021 |
| The role of SRGN in the survival and immune infiltrates of skin cutaneous melanoma (SKCM) and SKCM-metastasis patients. | The role of SRGN in the survival and immune infiltrates of skin cutaneous melanoma (SKCM) and SKCM-metastasis patients.
Wang X, Xiong H, Liang D, Chen Z, Li X, Zhang K., Free PMC Article | 12/19/2020 |
| Proteoglycan SRGN promotes NSCLC cell migration via the binding of its GAG motif to CD44. SRGN/CD44 interaction induces Rho-family GTPase-mediated cytoskeleton reorganization and facilitates Src-mediated focal adhesion turnover, leading to increased cell migration. | Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44.
Guo JY, Chiu CH, Wang MJ, Li FA, Chen JY., Free PMC Article | 06/6/2020 |
| Serglycin is increased in human chondrocytes after interleukin-1beta stimulation. It binds CD44 receptor to amplify the inflammatory response. | Serglycin as part of IL-1β induced inflammation in human chondrocytes.
Scuruchi M, D'Ascola A, Avenoso A, Mandraffino G G, Campo S S, Campo GM. | 02/29/2020 |
| The current study suggests that increased maternal serum serglycin is associated with fetal growth restriction in early-onset preeclampsia. | Increased levels of serum serglycin and agrin is associated with adverse perinatal outcome in early onset preeclampsia.
Gumus Guler B, Ozler S. | 02/15/2020 |
| Results show that serglycin associates with an aggressive mesenchymal phenotype in breast cancer cells that is accompanied by increased proteolytic potential, drug resistance and inflammatory response. IL-8 is highlighted as a key inflammatory mediator interconnected with serglycin in breast cancer cells that evokes an invasive phenotype via activation of various downstream signaling pathways. | Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling.
Bouris P, Manou D, Sopaki-Valalaki A, Kolokotroni A, Moustakas A, Kapoor A, Iozzo RV, Karamanos NK, Theocharis AD. | 07/6/2019 |
| SRGN overexpression promoted colorectal cancer cell migration and invasion and SRGN was physically binding to a hypoxia response element in its promoter region. | SRGN Promotes Colorectal Cancer Metastasis as a Critical Downstream Target of HIF-1α.
Xu Y, Xu J, Yang Y, Zhu L, Li X, Zhao W. | 09/15/2018 |
| SRGN secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44 | Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.
Guo JY, Hsu HS, Tyan SW, Li FY, Shew JY, Lee WH, Chen JY., Free PMC Article | 09/2/2017 |
| Extracellular spce serglycin upregulated CD44 receptor expression to maintain nasopharyngeal carcinoma stemness by interacting with CD44 and activating the MAPK/beta-catenin pathway. | Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis.
Chu Q, Huang H, Huang T, Cao L, Peng L, Shi S, Zheng L, Xu L, Zhang S, Huang J, Li X, Qian C, Huang B., Free PMC Article | 09/2/2017 |
| SRGN expression is significantly upregulated in human masticatory mucosa during wound healing | Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN. | 03/22/2017 |
| Patients with NPC with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases. | Serglycin expression: An independent marker of distant metastases in nasopharyngeal carcinoma.
Chia CS, Ong WS, Li XJ, Soong YL, Chong FT, Tan HK, Soo KC, Qian CN, Teh BT, Iyer NG. | 12/17/2016 |
| The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression | Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines.
Korpetinou A, Papachristou DJ, Lampropoulou A, Bouris P, Labropoulou VT, Noulas A, Karamanos NK, Theocharis AD., Free PMC Article | 09/10/2016 |
| These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development. | Serglycin in Quiescent and Proliferating Primary Endothelial Cells.
Reine TM, Vuong TT, Rutkovskiy A, Meen AJ, Vaage J, Jenssen TG, Kolset SO., Free PMC Article | 06/28/2016 |
| These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells. | Serglycin secretion is part of the inflammatory response in activated primary human endothelial cells in vitro.
Reine TM, Vuong TT, Jenssen TG, Kolset SO. | 09/6/2014 |
| The reduced expression of SRGN was accompanied by elevated levels of E-cadherin. | Serglycin (SRGN) overexpression predicts poor prognosis in hepatocellular carcinoma patients.
He L, Zhou X, Qu C, Tang Y, Zhang Q, Hong J. | 09/6/2014 |
| These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. | Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization.
Purushothaman A, Toole BP., Free PMC Article | 04/26/2014 |