| HES6 Mediates Oxidative Phosphorylation Pathway to Promote Immune Infiltration of CD8 + T Cells in Lung Adenocarcinoma. | HES6 Mediates Oxidative Phosphorylation Pathway to Promote Immune Infiltration of CD8 + T Cells in Lung Adenocarcinoma.
Chen Z, Wang Y, Tang W, Xu S, Yu H, Chen Z. | 10/9/2024 |
| The novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis. | The novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis.
Wang Z, Wang P, Zhang J, Gong H, Zhang X, Song J, Nie L, Peng Y, Li Y, Peng H, Cui Y, Li H, Hu B, Mi J, Liang L, Liu H, Zhang J, Ye M, Yazdanbakhsh K, Mohandas N, An X, Han X, Liu J., Free PMC Article | 06/13/2023 |
| ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease. | ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease.
Bai Z, Luo Y, Tian L., Free PMC Article | 10/8/2022 |
| Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease. | Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.
Pandiani C, Strub T, Nottet N, Cheli Y, Gambi G, Bille K, Husser C, Dalmasso M, Béranger G, Lassalle S, Magnone V, Pédeutour F, Irondelle M, Maschi C, Nahon-Estève S, Martel A, Caujolle JP, Hofman P, LeBrigand K, Davidson I, Baillif S, Barbry P, Ballotti R, Bertolotto C., Free PMC Article | 02/26/2022 |
| High HES6 expression is associated with metastasis in colorectal cancer. | Overexpression of HES6 has prognostic value and promotes metastasis via the Wnt/β-catenin signaling pathway in colorectal cancer.
Xu Y, Liu X, Zhang H, Zhu Z, Wu X, Wu X, Li S, Song L, Xu X., Free PMC Article | 11/10/2018 |
| prostate cancer-specific up-regulation of NOTCH3 and HES6, is reported. | HES6 promotes prostate cancer aggressiveness independently of Notch signalling.
Carvalho FL, Marchionni L, Gupta A, Kummangal BA, Schaeffer EM, Ross AE, Berman DM., Free PMC Article | 04/2/2016 |
| HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer. | DOT1L-HES6 fusion drives androgen independent growth in prostate cancer.
Annala M, Kivinummi K, Leinonen K, Tuominen J, Zhang W, Visakorpi T, Nykter M., Free PMC Article | 05/23/2015 |
| HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1. | HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.
Ramos-Montoya A, Lamb AD, Russell R, Carroll T, Jurmeister S, Galeano-Dalmau N, Massie CE, Boren J, Bon H, Theodorou V, Vias M, Shaw GL, Sharma NL, Ross-Adams H, Scott HE, Vowler SL, Howat WJ, Warren AY, Wooster RF, Mills IG, Neal DE., Free PMC Article | 12/27/2014 |
| HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility. | HES6 enhances the motility of alveolar rhabdomyosarcoma cells.
Wickramasinghe CM, Domaschenz R, Amagase Y, Williamson D, Missiaglia E, Shipley J, Murai K, Jones PH. | 01/26/2013 |
| HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. | HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.
Haapa-Paananen S, Kiviluoto S, Waltari M, Puputti M, Mpindi JP, Kohonen P, Tynninen O, Haapasalo H, Joensuu H, Perälä M, Kallioniemi O. | 04/28/2012 |
| Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells. | Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation.
Hartman J, Lam EW, Gustafsson JA, Ström A., Free PMC Article | 07/12/2010 |
| These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed. | Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response.
Glubb DM, Joyce PR, Kennedy MA, Glubb DM, Joyce PR, Kennedy MA. | 01/21/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response.
Glubb DM, Joyce PR, Kennedy MA, Glubb DM, Joyce PR, Kennedy MA. | 06/24/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | A common variant in DRD3 receptor is associated with autism spectrum disorder.
de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM. | 01/11/2009 |
| the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways. | Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body.
Eun B, Lee Y, Hong S, Kim J, Lee HW, Kim K, Sun W, Kim H. | 01/21/2010 |
| ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter | Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells.
Scheffer D, Sage C, Corey DP, Pingault V. | 01/21/2010 |
| Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation. | The conserved WRPW motif of Hes6 mediates proteasomal degradation.
Kang SA, Seol JH, Kim J. | 01/21/2010 |
| Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity. | Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.
Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S., Free PMC Article | 01/21/2010 |
| Differentially expressed in metastatic colon carcinoma | Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array.
Swearingen ML, Sun D, Bourner M, Weinstein EJ. | 01/21/2010 |
| Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. | Impaired expression of Notch signaling genes in aged human skeletal muscle.
Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D. | 01/21/2010 |
| Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin expression | HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion.
Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F., Free PMC Article | 01/21/2010 |