| Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state. | Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state.
Siebert V, Silber M, Heuten E, Muhle-Goll C, Lemberg MK., Free PMC Article | 10/15/2022 |
| Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies. | Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.
Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R. | 06/19/2021 |
| Proapoptotic Mitochondrial Carrier Homolog Protein PSAP Mediates Death Receptor 6 Induced Apoptosis. | Proapoptotic Mitochondrial Carrier Homolog Protein PSAP Mediates Death Receptor 6 Induced Apoptosis.
Zhang J, Zhao ZJ, Fu X, Niu H, Hu C, Dong Y, Cui MZ, Zhang F, Zeng L, Xu X. | 05/8/2021 |
| PARL Protease: A Glimpse at Intramembrane Proteolysis in the Inner Mitochondrial Membrane. | PARL Protease: A Glimpse at Intramembrane Proteolysis in the Inner Mitochondrial Membrane.
Lysyk L, Brassard R, Touret N, Lemieux MJ. | 02/2/2021 |
| PARL preserves mitochondrial membrane homeostasis via STARD7 processing and is emerging as a critical regulator of protein localization between mitochondria and the cytosol | PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria.
Saita S, Tatsuta T, Lampe PA, König T, Ohba Y, Langer T., Free PMC Article | 10/27/2018 |
| Study confirmed that common variants in PARL and PINK1 were associated with leprosy. Furthermore, PARL and PINK1 could physically interact with each other and were involved in the highly connected network formed by reported leprosy susceptibility genes. | Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China.
Wang D, Zhang DF, Feng JQ, Li GD, Li XA, Yu XF, Long H, Li YY, Yao YG., Free PMC Article | 05/12/2018 |
| PDK2/PARL senses defects in mitochondrial bioenergetics. | The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism.
Shi G, McQuibban GA. | 12/2/2017 |
| Adipogenic process can be dissected into 3 stages according to the participation of PARL-PINK1-Parkin system. Findings reveal the sequential adipogenic events directed by PARL-PINK1-Parkin system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease | Role of PARL-PINK1-Parkin pathway in adipocyte differentiation.
Shiau MY, Lee PS, Huang YJ, Yang CP, Hsiao CW, Chang KY, Chen HW, Chang YH. | 09/23/2017 |
| These findings enrich the allelic spectrum of ABCC5 in PACG. We identified no tagging SNP responsible for the association of the whole region. | Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese.
Tang FY, Ma L, Tam POS, Pang CP, Tham CC, Chen LJ. | 08/26/2017 |
| These results reveal a pro-apoptotic function of PARL and identify PARL-mediated Smac processing and cytochrome c release facilitated by OPA1-dependent cristae remodelling as two independent pro-apoptotic pathways in mitochondria. | PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T. | 06/24/2017 |
| Its mutations are a rare cause of PD and genetic variants are neither strong nor common risk factors in Parkinson disease. | Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease.
Wüst R, Maurer B, Hauser K, Woitalla D, Sharma M, Krüger R. | 12/17/2016 |
| pathogenic PINK1 mutants which are not cleaved by PARL affect PINK1 kinase activity and the ability to induce PARK2-mediated mitophagy. | Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Meissner C, Lorenz H, Hehn B, Lemberg MK., Free PMC Article | 06/28/2016 |
| Common genetic variants of the PINK1 and PARL genes are unlikely to be involved in schizophrenia. | Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese.
Li X, Zhang W, Zhang C, Yi Z, Zhang DF, Gong W, Tang J, Wang D, Lu W, Chen X, Fang Y, Yao YG. | 05/23/2015 |
| the frequency of the haplotype AAC, and AAT were significantly higher in the unaffected cases and the frequencies of haplotype GGT were significantly higher in LHON cases | Identification of the variants in PARL, the nuclear modifier gene, responsible for the expression of LHON patients in Thailand.
Istikharah R, Tun AW, Kaewsutthi S, Aryal P, Kunhapan B, Katanyoo W, Chuenkongkaew W, Lertrit P. | 02/15/2014 |
| Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. | Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
Sekine S, Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda K, Ichijo H., Free PMC Article | 01/5/2013 |
| p.S77N variant, and, possibly, mutations in the PARL protein overall, are not a frequent cause of autosomal recessive early-onset Parkinson's disease | The p.S77N presenilin-associated rhomboid-like protein mutation is not a frequent cause of early-onset Parkinson's disease.
Heinitz S, Klein C, Djarmati A. | 06/2/2012 |
| work provides unexpected insights into the structural determinants regulating Parl stability and activity in vivo, and reveals a complex cascade of proteolytic events controlling the function of the protease in the mitochondrion | Structural and mechanistic basis of Parl activity and regulation.
Jeyaraju DV, McBride HM, Hill RB, Pellegrini L., Free PMC Article | 11/19/2011 |
| PARL deficiency impairs PARKIN recruitment to mitochondria. | Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease.
Shi G, Lee JR, Grimes DA, Racacho L, Ye D, Yang H, Ross OA, Farrer M, McQuibban GA, Bulman DE. | 08/13/2011 |
| the PARL-catalyzed removal of the Pink1 signal sequence in the canonical import pathway acts as a cellular checkpoint for mitochondrial integrity | The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.
Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK. | 07/2/2011 |
| Mitochondrial protease PARL cleaves PINK1 at position A103. | PINK1 cleavage at position A103 by the mitochondrial protease PARL.
Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, Wood NW., Free PMC Article | 05/28/2011 |
| Data show that no association between PARL gene SNPs and LHON in Chinese patients with m.11778G>A. | No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A.
Zhang AM, Jia X, Zhang Q, Yao YG. | 11/6/2010 |
| variants of PARL are suggested to influence cell death by apoptosis which has long been believed to intrigue the neurodegeneration of LHON. | Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand.
Phasukkijwatana N, Kunhapan B, Stankovich J, Chuenkongkaew WL, Thomson R, Thornton T, Bahlo M, Mushiroda T, Nakamura Y, Mahasirimongkol S, Tun AW, Srisawat C, Limwongse C, Peerapittayamongkol C, Sura T, Suthammarak W, Lertrit P. | 07/5/2010 |
| Results suggest that genetic variation within PARL influences mitochondrial abundance and integrity. | Genetic variation in PARL influences mitochondrial content.
Curran JE, Jowett JB, Abraham LJ, Diepeveen LA, Elliott KS, Dyer TD, Kerr-Bayles LJ, Johnson MP, Comuzzie AG, Moses EK, Walder KR, Collier GR, Blangero J, Kissebah AH., Free PMC Article | 02/15/2010 |
| results indicate a different function and mechanism of Hax1 in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 processing. | Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis.
Jeyaraju DV, Cisbani G, De Brito OM, Koonin EV, Pellegrini L., Free PMC Article | 01/21/2010 |
| Genetic variation of PARL may indicate earlier onset of type 2 diabetes and increased susceptibility to nephropathy and cardiovascular complications. | The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population.
Hatunic M, Stapleton M, Hand E, DeLong C, Crowley VE, Nolan JJ. | 01/21/2010 |