| A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells. | A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.
Schmit MM, Baxley RM, Wang L, Hinderlie P, Kaufman M, Simon E, Raju A, Miller JS, Bielinsky AK., Free PMC Article | 02/5/2024 |
| MCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer. | MCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer.
Chen D, Zhong N, Guo Z, Ji Q, Dong Z, Zheng J, Ma Y, Zhang J, He Y, Song T., Free PMC Article | 11/1/2023 |
| Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation. | Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation.
Caballero M, Ge T, Rebelo AR, Seo S, Kim S, Brooks K, Zuccaro M, Kanagaraj R, Vershkov D, Kim D, Smogorzewska A, Smolka M, Benvenisty N, West SC, Egli D, Mace EM, Koren A., Free PMC Article | 09/17/2022 |
| Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer. | Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer.
Mughal MJ, Chan KI, Mahadevappa R, Wong SW, Wai KC, Kwok HF., Free PMC Article | 07/23/2022 |
| Prognostic significance and function of MCM10 in human hepatocellular carcinoma. | Prognostic significance and function of MCM10 in human hepatocellular carcinoma.
Chen YR, Li YT, Wang MQ, Zhu SL. | 02/19/2022 |
| Aberrant MCM10 SUMOylation induces genomic instability mediated by a genetic variant associated with survival of esophageal squamous cell carcinoma. | Aberrant MCM10 SUMOylation induces genomic instability mediated by a genetic variant associated with survival of esophageal squamous cell carcinoma.
Tian J, Lu Z, Niu S, Zhang S, Ying P, Wang L, Zhang M, Cai Y, Dong T, Zhu Y, Zhong R, Wang Z, Chang J, Miao X., Free PMC Article | 02/12/2022 |
| BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage. | BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage.
Kang Z, Fu P, Alcivar AL, Fu H, Redon C, Foo TK, Zuo Y, Ye C, Baxley R, Madireddy A, Buisson R, Bielinsky AK, Zou L, Shen Z, Aladjem MI, Xia B., Free PMC Article | 11/6/2021 |
| Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening. | Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening.
Baxley RM, Leung W, Schmit MM, Matson JP, Yin L, Oram MK, Wang L, Taylor J, Hedberg J, Rogers CB, Harvey AJ, Basu D, Taylor JC, Pagnamenta AT, Dreau H, Craft J, Ormondroyd E, Watkins H, Hendrickson EA, Mace EM, Orange JS, Aihara H, Stewart GS, Blair E, Cook JG, Bielinsky AK., Free PMC Article | 04/3/2021 |
| MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells. | MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells.
Murayama T, Takeuchi Y, Yamawaki K, Natsume T, Li M, Marcela RN, Nishimura T, Kogure Y, Nakata A, Tominaga K, Sasahara A, Yano M, Ishikawa S, Ohta T, Ikeda K, Horie-Inoue K, Inoue S, Seki M, Suzuki Y, Sugano S, Enomoto T, Tanabe M, Tada KI, Kanemaki MT, Okamoto K, Tojo A, Gotoh N., Free PMC Article | 03/20/2021 |
| Knockdown of MCM10 Gene Impairs Glioblastoma Cell Proliferation, Migration and Invasion and the Implications for the Regulation of Tumorigenesis. | Knockdown of MCM10 Gene Impairs Glioblastoma Cell Proliferation, Migration and Invasion and the Implications for the Regulation of Tumorigenesis.
Kang P, Han Z, Liao Z, Zhang H, Jia W, Tian Y. | 01/9/2021 |
| High MCM10 expression is associated with lung adenocarcinoma. | Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma.
Li S, Jiang Z, Li Y, Xu Y., Free PMC Article | 04/18/2020 |
| MCM10 is highly expressed in lung cancer (LC) clinical specimens and significantly associated with recurrence, pathological stage and worse overall survival. MCM10 knockdown in A549 and H661 cell lines significantly suppressed cell viability, clone formation and induced G1 phase arrest by regulating the expression of CCND1. Results indicated a combined effect of MCM10CCND1 in predicting the prognosis of LC patients. | Minichromosome maintenance protein 10 as a marker for proliferation and prognosis in lung cancer.
Wang M, Xie S, Yuan W, Xie T, Jamal M, Huang J, Yin Q, Song H, Zhang Q. | 04/4/2020 |
| decreased expression of beta-catenin and cyclin Dl was detected in MCM10 short hairpin RNA cells, implying that MCM10 might induce breast cancer metastasis via the Wnt/beta-catenin pathway.MCM10 can be defined as a potential diagnostic tool and a promising target for breast carcinoma. | MCM10 facilitates the invaded/migrated potentials of breast cancer cells via Wnt/β-catenin signaling and is positively interlinked with poor prognosis in breast carcinoma.
Yang WD, Wang L. | 07/27/2019 |
| MCM10 was significantly upregulated in prostate cancer (PCa). We found increased MCM10 expression was significantly associated with advanced clinical stage and high Gleason score PCa. higher MCM10 expression was associated with a poorer patient prognosis in PCa. Furthermore, loss of function assays showed that MCM10 knockdown inhibited cell proliferation and colony formation, but promoted cell apoptosis. | Overexpression of MCM10 promotes cell proliferation and predicts poor prognosis in prostate cancer.
Cui F, Hu J, Ning S, Tan J, Tang H., Free PMC Article | 06/1/2019 |
| Results show that MCM10 is significantly upregulated in urothelial carcinoma (UC), and associated with tumor aggressiveness. Its knockdown significantly suppressed cell proliferation in UC cell lines. | MCM10 overexpression implicates adverse prognosis in urothelial carcinoma.
Li WM, Huang CN, Ke HL, Li CC, Wei YC, Yeh HC, Chang LL, Huang CH, Liang PI, Yeh BW, Chan TC, Li CF, Wu WJ., Free PMC Article | 02/24/2018 |
| Data suggest that interaction of Mcm10 with Mcm2-7 multimer requires Mcm10 domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 on chromatin; Mcm10 conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7-binding domain are required for full activity of Mcm10. | The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.
Izumi M, Mizuno T, Yanagi KI, Sugimura K, Okumura K, Imamoto N, Abe T, Hanaoka F., Free PMC Article | 08/26/2017 |
| RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells. | RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells.
Im JS, Park SY, Cho WH, Bae SH, Hurwitz J, Lee JK., Free PMC Article | 01/2/2016 |
| MCM10 is the natural substrate of the Cul4-DDB1[VprBP] E3 ubiquitin ligase whose degradation is regulated by VprBP, but Vpr enhances the proteasomal degradation of MCM10 by interacting with VprBP. | HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.
Romani B, Shaykh Baygloo N, Aghasadeghi MR, Allahbakhshi E., Free PMC Article | 10/3/2015 |
| Loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. [Review] | MCM10: one tool for all-Integrity, maintenance and damage control.
Thu YM, Bielinsky AK., Free PMC Article | 01/17/2015 |
| Mcm10 utilizes a modular architecture to act as a replisome scaffold, which helps to define possible roles in origin DNA melting, Pol alpha recruitment and coordination of enzymatic activities during elongation. | Structural biology of replication initiation factor Mcm10.
Du W, Stauffer ME, Eichman BF., Free PMC Article | 02/22/2014 |
| Data suggest that CDC45 and MCM10 (minichromosome maintenance complex component 10) directly interact and establish a mutual co-operation in DNA binding; key domains appear to interact and then interact with DNA inside cells or in cell-free systems. | The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties.
Di Perna R, Aria V, De Falco M, Sannino V, Okorokov AL, Pisani FM, De Felice M. | 11/16/2013 |
| This report shows that human Mcm10 is an acetylated protein regulated by SIRT1, which binds and deacetylates Mcm10 both in vivo and in vitro, and modulates Mcm10 stability and ability to bind DNA. | Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation.
Fatoba ST, Tognetti S, Berto M, Leo E, Mulvey CM, Godovac-Zimmermann J, Pommier Y, Okorokov AL., Free PMC Article | 06/22/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| High doses of ionizing gamma radiation and exposure to a combination of DNA-damaging chemicals do not decrease Mcm10 protein levels, demonstrating that Mcm10 down-regulation is triggered only by UV-specific damage | Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10.
Sharma A, Kaur M, Kar A, Ranade SM, Saxena S., Free PMC Article | 04/19/2010 |
| MCM10 interacts directly with RECQ4 and regulates its DNA unwinding activity. | MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.
Xu X, Rochette PJ, Feyissa EA, Su TV, Liu Y., Free PMC Article | 01/21/2010 |