| Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/beta-catenin signaling pathway. | Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway.
Bi Y, Zhang L, Song Y, Sun L, Mulholland MW, Yin Y, Zhang W., | 03/27/2024 |
| Identification of LGR4 as a prognostic biomarker in KRAS-mutant lung adenocarcinoma: Evidence from integrated bioinformatics analysis. | Identification of LGR4 as a prognostic biomarker in KRAS-mutant lung adenocarcinoma: Evidence from integrated bioinformatics analysis.
Dodin Y., Free PMC Article | 11/27/2023 |
| LGR4 promotes tumorigenesis by activating TGF-beta1/Smad signaling pathway in multiple myeloma. | LGR4 promotes tumorigenesis by activating TGF-β1/Smad signaling pathway in multiple myeloma.
Yi Z, Ma T, Liu J, Tie W, Li Y, Bai J, Li L, Zhang L. | 09/6/2023 |
| LGR4: A New Receptor Member in Endocrine and Metabolic Diseases. | LGR4: A New Receptor Member in Endocrine and Metabolic Diseases.
Zhang N, Yuan M, Wang J., Free PMC Article | 07/19/2023 |
| Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation. | Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation.
Lucas C, Sauter KS, Steigert M, Mallet D, Wilmouth J, Olabe J, Plotton I, Morel Y, Aeberli D, Wagner F, Clevers H, Pandey AV, Val P, Roucher-Boulez F, Flück CE., Free PMC Article | 03/6/2023 |
| Bioinformatics Analysis of LGR4 in Colon Adenocarcinoma as Potential Diagnostic Biomarker, Therapeutic Target and Promoting Immune Cell Infiltration. | Bioinformatics Analysis of LGR4 in Colon Adenocarcinoma as Potential Diagnostic Biomarker, Therapeutic Target and Promoting Immune Cell Infiltration.
Wu L, Tian X, Du H, Liu X, Wu H., Free PMC Article | 09/3/2022 |
| RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis. | RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.
Yue Z, Niu X, Yuan Z, Qin Q, Jiang W, He L, Gao J, Ding Y, Liu Y, Xu Z, Li Z, Yang Z, Li R, Xue X, Gao Y, Yue F, Zhang XH, Hu G, Wang Y, Li Y, Chen G, Siwko S, Gartland A, Wang N, Xiao J, Liu M, Luo J., Free PMC Article | 02/19/2022 |
| Clinical Significance of Stem Cell Biomarkers EpCAM, LGR5 and LGR4 mRNA Levels in Lymph Nodes of Colon Cancer Patients. | Clinical Significance of Stem Cell Biomarkers EpCAM, LGR5 and LGR4 mRNA Levels in Lymph Nodes of Colon Cancer Patients.
AbdelMageed M, Ismail HTH, Olsson L, Lindmark G, Hammarström ML, Hammarström S, Sitohy B., Free PMC Article | 02/5/2022 |
| LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families. | LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families.
Shi SQ, Li SS, Zhang XY, Wei Z, Fu WZ, He JW, Hu YQ, Li M, Zheng LL, Zhang ZL., Free PMC Article | 12/25/2021 |
| LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation. | LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation.
Wang Y, Wang H, Guo J, Gao J, Wang M, Xia M, Wen Y, Su P, Yang M, Liu M, Shi L, Cheng T, Zhou W, Zhou J. | 06/5/2021 |
| The Role of LGR4 (GPR48) in Normal and Cancer Processes. | The Role of LGR4 (GPR48) in Normal and Cancer Processes.
Ordaz-Ramos A, Rosales-Gallegos VH, Melendez-Zajgla J, Maldonado V, Vazquez-Santillan K., Free PMC Article | 05/29/2021 |
| LGR4 deficiency results in delayed puberty through impaired Wnt/beta-catenin signaling. | LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling.
Mancini A, Howard SR, Marelli F, Cabrera CP, Barnes MR, Sternberg MJ, Leprovots M, Hadjidemetriou I, Monti E, David A, Wehkalampi K, Oleari R, Lettieri A, Vezzoli V, Vassart G, Cariboni A, Bonomi M, Garcia MI, Guasti L, Dunkel L., Free PMC Article | 05/22/2021 |
| MicroRNA137 regulates hypoxiamediated migration and epithelialmesenchymal transition in prostate cancer by targeting LGR4 via the EGFR/ERK signaling pathway. | MicroRNA‑137 regulates hypoxia‑mediated migration and epithelial‑mesenchymal transition in prostate cancer by targeting LGR4 via the EGFR/ERK signaling pathway.
Zhang H, Liang F, Yue J, Liu P, Wang J, Wang Z, Li H, Cheng D, Du J, Zhang K, Du P. | 05/8/2021 |
| LGR4 maintains HGSOC cell epithelial phenotype and stem-like traits. | LGR4 maintains HGSOC cell epithelial phenotype and stem-like traits.
Wang Z, Yin P, Sun Y, Na L, Gao J, Wang W, Zhao C. | 04/24/2021 |
| Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia. | Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia.
Salik B, Yi H, Hassan N, Santiappillai N, Vick B, Connerty P, Duly A, Trahair T, Woo AJ, Beck D, Liu T, Spiekermann K, Jeremias I, Wang J, Kavallaris M, Haber M, Norris MD, Liebermann DA, D'Andrea RJ, Murriel C, Wang JY. | 03/13/2021 |
| LGR4 overexpression is associated with clinical parameters and poor prognosis of serous ovarian cancer. | LGR4 overexpression is associated with clinical parameters and poor prognosis of serous ovarian cancer.
Zeng Z, Ji N, Yi J, Lv J, Yuan J, Lin Z, Liu L, Feng X. | 02/6/2021 |
| Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells. | Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells.
Liang F, Zhang H, Cheng D, Gao H, Wang J, Yue J, Zhang N, Wang J, Wang Z, Zhao B. | 02/6/2021 |
| Association between LGR4 polymorphisms and peak bone mineral density and body composition. | Association between LGR4 polymorphisms and peak bone mineral density and body composition.
Yu WJ, Zhang Z, Fu WZ, He JW, Wang C, Zhang ZL. | 10/3/2020 |
| MicroRNA-34a negatively controls LGR4, thereby inhibiting the migration and invasion of uveal melanoma cells. Ultimately, both miR-34a and LGR4 impact the aggressiveness of uveal melanoma with alterations in the markers of the epithelial-mesenchymal transition. | The Interplay of MicroRNA-34a, LGR4, EMT-Associated Factors, and MMP2 in Regulating Uveal Melanoma Cells.
Hou Q, Han S, Yang L, Chen S, Chen J, Ma N, Wang C, Tang J, Chen X, Chen F, Dong XDE, Tu L. | 01/25/2020 |
| our studies demonstrate that Rspo2-LGR4 is crucial for the growth, migration and invasion, EMT and stem-like properties of TSCC cells. These actions occur through the activation of Wnt/beta-catenin signaling pathway. | R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling.
Zhang L, Song Y, Ling Z, Li Y, Ren X, Yang J, Wang Z, Xia J, Zhang W, Cheng B., Free PMC Article | 12/21/2019 |
| High expression of LGR4 is associated with Primary intestinal-type carcinomas than diffuse tumours. | Immunoexpression of LGR4 and Β-Catenin in Gastric Cancer and Normal Gastric Mucosa.
Souza SM, Valiente AEF, Sá KM, Juanes CC, Rodrigues BJ, Farias ACC, Campelo CC, Silva PGB, Almeida PRC., Free PMC Article | 07/13/2019 |
| The miR-193a-3p regulates osteoblast differentiation by modulating LGR4/ATF4 signaling and suggests that the miR-193a-3p/LGR4/ATF4 regulation axis may play an important role in regulating bone remodeling. | Down-regulation of miR-193a-3p promotes osteoblast differentiation through up-regulation of LGR4/ATF4 signaling.
Wang W, Chen J, Hui Y, Huang M, Yuan P. | 05/18/2019 |
| findings support a crucial role of the Wnt signaling component LGR4 in breast cancer initiation, metastasis, and breast cancer stem cell. | LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.
Yue Z, Yuan Z, Zeng L, Wang Y, Lai L, Li J, Sun P, Xue X, Qi J, Yang Z, Zheng Y, Fang Y, Li D, Siwko S, Li Y, Luo J, Liu M., Free PMC Article | 01/12/2019 |
| Loss of LGR4 abrogated RSPO3-regulated osteogenesis and RSPO3-induced ERK1/2 signalling inhibition. | RSPO3-LGR4 Regulates Osteogenic Differentiation Of Human Adipose-Derived Stem Cells Via ERK/FGF Signalling.
Zhang M, Zhang P, Liu Y, Lv L, Zhang X, Liu H, Zhou Y., Free PMC Article | 11/10/2018 |
| Luciferase reporter assay was performed to confirm that LGR4 is a direct target gene of miR-137 with a potential binding site in the 3'UTR of LGR4. | MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression.
Liu X, Xu X. | 10/13/2018 |