| There is no correlation between single CHDH rs893363 and CHDH rs2289205 polymorphisms and the incidence of intrauterine fetal death. | Polymorphic variants of genes involved in choline pathway and the risk of intrauterine fetal death.
Drews K, Różycka A, Barlik M, Klejewski A, Kurzawińska G, Wolski H, Majchrzycki M, Gryszczyńska A, Kamiński A, Seremak-Mrozikiewicz A. | 08/4/2018 |
| CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous brains of bipolar disorder genome-wide association studies | Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.
Chang H, Li L, Peng T, Grigoroiu-Serbanescu M, Bergen SE, Landén M, Hultman CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Cichon S, Nöthen MM, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Rietschel M, Swedish Bipolar Study Group, MooDS Consortium, Xiao X, Li M. | 05/12/2018 |
| In genotypic combination analysis considering PEMT -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342). | Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment.
Jaiswal SK, Sukla KK, Chauhan A, Lakhotia AR, Kumar A, Rai AK. | 01/13/2018 |
| CHDH is not a substrate of PARK2 but interacts with SQSTM1 independently of PARK2 to recruit SQSTM1 into depolarized mitochondria | Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Park S, Choi SG, Yoo SM, Son JH, Jung YK., Free PMC Article | 09/26/2015 |
| the PEMT -774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality | Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration.
Lazaros L, Xita N, Hatzi E, Kaponis A, Makrydimas G, Takenaka A, Sofikitis N, Stefos T, Zikopoulos K, Georgiou I., Free PMC Article | 01/26/2013 |
| The rs12676 single nucleotide polymorphism is associated with altered sperm motility patterns and dysmorphic mitochondrial structure in sperm. | Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function.
Johnson AR, Lao S, Wang T, Galanko JA, Zeisel SH., Free PMC Article | 09/8/2012 |
| CHDH and PLD2 as novel candidate genes, the nucleotide variants of which could be associated with the risk of tooth agenesis. | Polymorphisms in CHDH gene and the risk of tooth agenesis.
Mostowska A, Biedziak B, Dunin-Wilczynska I, Komorowska A, Jagodzinski PP. | 07/2/2011 |
| CHDH A119C and MTHFR C677T play an important role in modulating the homocysteine levels in Indian population. | Single nucleotide polymorphisms in homocysteine metabolism pathway genes: association of CHDH A119C and MTHFR C677T with hyperhomocysteinemia.
Kumar J, Garg G, Kumar A, Sundaramoorthy E, Sanapala KR, Ghosh S, Karthikeyan G, Ramakrishnan L, Indian Genome Variation Consortium, Sengupta S. | 03/8/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (3) articlesPolymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.
Mostowska A, Hozyasz KK, Biedziak B, Misiak J, Jagodzinski PP. Cystathionine beta-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population.
Kumar J, Garg G, Karthikeyan G, Sengupta S. Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.
Mostowska A, Hozyasz KK, Wojcicki P, Dziegelewska M, Jagodzinski PP. | 09/20/2009 |
| single nucleotide polymorphisms of choline-metabolizing genes, PEMT -774G>C (rs12325817) and CHDH +432G>T (rs12676), were found be related to breast cancer risk | Choline metabolism and risk of breast cancer in a population-based study.
Xu X, Gammon MD, Zeisel SH, Lee YL, Wetmur JG, Teitelbaum SL, Bradshaw PT, Neugut AI, Santella RM, Chen J, Xu X, Gammon MD, Zeisel SH, Lee YL, Wetmur JG, Teitelbaum SL, Bradshaw PT, Neugut AI, Santella RM, Chen J., Free PMC Articles: PMC2430758, PMC2430758 | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Choline metabolism and risk of breast cancer in a population-based study.
Xu X, Gammon MD, Zeisel SH, Lee YL, Wetmur JG, Teitelbaum SL, Bradshaw PT, Neugut AI, Santella RM, Chen J, Xu X, Gammon MD, Zeisel SH, Lee YL, Wetmur JG, Teitelbaum SL, Bradshaw PT, Neugut AI, Santella RM, Chen J., Free PMC Articles: PMC2430758, PMC2430758 | 04/3/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Common genetic polymorphisms affect the human requirement for the nutrient choline.
da Costa KA, Kozyreva OG, Song J, Galanko JA, Fischer LM, Zeisel SH. | 03/13/2008 |
| HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer | The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer.
Wang Z, Dahiya S, Provencher H, Muir B, Carney E, Coser K, Shioda T, Ma XJ, Sgroi DC. | 01/21/2010 |