| PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca[2+] Influx. | PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca(2+) Influx.
Li M, Gong W, Chen J, Zhang Y, Ma Y, Tu X., Free PMC Article | 03/27/2023 |
| The CnB1 p.D102A variant is linked to dilated cardiomyopathy via impaired Calcineurin activity. | The CnB1 p.D102A variant is linked to dilated cardiomyopathy via impaired Calcineurin activity.
Jinqiang Zhuang MD, Ruijun Yuan MD, Yizeng MD, Congliang Miao MD, Dandan Zhou MD, Anli Na MD, Xinying Yang MD, Hui Xu MD, Hong J. | 08/14/2021 |
| A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58. | A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.
Lezirovitz K, Vieira-Silva GA, Batissoco AC, Levy D, Kitajima JP, Trouillet A, Ouyang E, Zebarjadi N, Sampaio-Silva J, Pedroso-Campos V, Nascimento LR, Sonoda CY, Borges VM, Vasconcelos LG, Beck RMO, Grasel SS, Jagger DJ, Grillet N, Bento RF, Mingroni-Netto RC, Oiticica J., Free PMC Article | 08/14/2021 |
| iTRAQ results show that let-7e is associated with the expression of anti-viral proteins. What's more, calcineurin subunit B type 1, an anti-tumor factor, is upregulated by let-7e after LPS stimulation | Effects of let-7e on LPS-Stimulated THP-1 Cells Assessed by iTRAQ Proteomic Analysis.
Gui L, Zhang Q, Cai Y, Deng X, Zhang Y, Li C, Guo Q, He X, Huang J. | 04/6/2019 |
| expression of PPP3R1 decreased respectively in psoriatic lesions and HaCaT cells. | MiR-548a-3p Promotes Keratinocyte Proliferation Targeting PPP3R1 after Being Induced by IL-22.
Zhao X, Li R, Qiao M, Yan J, Sun Q. | 10/6/2018 |
| The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels. | Association of CnB 5I/5D promoter gene polymorphism and serum calcineurin levels in early onset of coronary artery disease of south Indian cohort.
Maddhuri S, Bandaru S, Bhukya C, Cingeetham V, Malempati AR, Deepika MLN, Nallari P, Mundluru HP. | 10/7/2017 |
| The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients | Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy.
Chang TH, Chen MC, Chang JP, Huang HD, Ho WC, Lin YS, Pan KL, Huang YK, Liu WH, Wu CC., Free PMC Article | 07/1/2017 |
| we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4/MD2 complex together with the co-receptor CD14 | Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4.
Yang J, Qin N, Zhang H, Yang R, Xiang B, Wei Q., Free PMC Article | 03/11/2017 |
| CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 signaling through TRAF3 and TRAF6, in response to various agonists. | Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway.
Wu W, Chen Q, Geng F, Tong L, Yang R, Yang J, Zhang H, Jia Z, Wei Q., Free PMC Article | 12/17/2016 |
| Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B. | Placenta-specific miRNA (miR-512-3p) targets PPP3R1 encoding the calcineurin B regulatory subunit in BeWo cells.
Kurashina R, Kikuchi K, Iwaki J, Yoshitake H, Takeshita T, Takizawa T. | 04/11/2015 |
| Further evidence that specific variations in MAPT (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease | Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study.
Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JC, Welsh-Bohmer KA, Lyketsos C, Tschanz J, Kauwe JS, Alzheimer's Disease Neuroimaging Initiative., Free PMC Article | 12/20/2014 |
| Expression level of PPP3R1 and GATA4, and NFATC4 genes for transcription factors did not differ in studied subgroups of patients. | [Expression profile of calcineurin pathway genes in myocardium tissues in relation to ischemic heart remodeling in humans].
Polovlkova OG, Makeeva OA, Lezhnev AA, Goncharova IA, Kulish EV, Shipulin VM, Puzyrev VP. | 08/31/2013 |
| Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion. | Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.
Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK., Free PMC Article | 10/13/2012 |
| These findings reveal a novel signaling pathway (CnB-CD11b-NF-kappaB-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity. | The calcineurin B subunit induces TNF-related apoptosis-inducing ligand (TRAIL) expression via CD11b-NF-κB pathway in RAW264.7 macrophages.
Su Z, Xin S, Xu L, Cheng J, Guo J, Li L, Wei Q. | 03/17/2012 |
| immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection | Calcineurin subunit B is an immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection.
Li J, Hu M, Guo J, Su Z, Wei Q. | 12/24/2011 |
| CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells. | Mutation of calcineurin subunit B M118 influences the activities of NF-AT and p53, but not calcineurin expression level.
Cheng J, Tang W, Su Z, Wei Q. | 12/10/2011 |
| Findings demonstrate that CaN functions as a critical signaling molecule during Th cell activation, regulating Bcl-10 phosphorylation and NF-kappaB activation. | Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-κB activation in Th cells.
Frischbutter S, Gabriel C, Bendfeldt H, Radbruch A, Baumgrass R. | 10/8/2011 |
| CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway. | Calcineurin B subunit interacts with proteasome subunit alpha type 7 and represses hypoxia-inducible factor-1α activity via the proteasome pathway.
Li N, Zhang Z, Zhang W, Wei Q. | 04/9/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesUsing genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.
Wang P, Mao Y, Razo J, Zhou X, Wong ST, Patel S, Elliott E, Shea E, Wu AH, Gaber AO. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. | 09/15/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.
He ZH, Hu Y, Li YC, Bao DP, Ruiz JR, Lucia A. | 09/15/2010 |
| Data suggest an association between polymorphisms in PPP3CA, PPP3R1 and PPP3R2 and baseline levels or trainability of endurance phenotype traits. | Are calcineurin genes associated with endurance phenotype traits?
He ZH, Hu Y, Wang HY, Li YC, Lu YL, Zhang L, Bao BP, Ruiz JR, Lucia A. | 09/6/2010 |
| A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. | A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
Rodríguez A, Roy J, Martínez-Martínez S, López-Maderuelo MD, Niño-Moreno P, Ortí L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM., Free PMC Article | 01/21/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article | 02/11/2009 |
| Study found that although calcineurin/NFAT signalling pathway has an important, non-redundant role in the regulation of lymphocyte developmental checkpoints, it is not essential for the development of blood myeloid lineages. | Selective role of calcineurin in haematopoiesis and lymphopoiesis.
Gallo EM, Ho L, Winslow MM, Staton TL, Crabtree GR., Free PMC Article | 01/21/2010 |
| CNB gene 5I/5D polymorphism is associated with the risk of left ventricular hypertrophy and physical performance of athletes. | [The influence of calcineurin gene polymorphism on morphofunctional characteristics of cardiovascular system of athletes].
Akhmetov II, Linde EV, Shikhova IuV, Popov DV, Missina SS, Vinogradoba OL, Rogozkin VA. | 01/21/2010 |