| A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination. | A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination.
Ambjørn SM, Duxin JP, Hertz EPT, Nasa I, Duro J, Kruse T, Lopez-Mendez B, Rymarczyk B, Cressey LE, van Overeem Hansen T, Kettenbach AN, Oestergaard VH, Lisby M, Nilsson J., Free PMC Article | 10/23/2021 |
| Selective PP2A Enhancement through Biased Heterotrimer Stabilization. | Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Leonard D, Huang W, Izadmehr S, O'Connor CM, Wiredja DD, Wang Z, Zaware N, Chen Y, Schlatzer DM, Kiselar J, Vasireddi N, Schüchner S, Perl AL, Galsky MD, Xu W, Brautigan DL, Ogris E, Taylor DJ, Narla G., Free PMC Article | 01/9/2021 |
| Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling. | Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.
Salamango DJ, McCann JL, Demir Ö, Becker JT, Wang J, Lingappa JR, Temiz NA, Brown WL, Amaro RE, Harris RS., Free PMC Article | 01/2/2021 |
| HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators. | HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators.
Salamango DJ, Ikeda T, Moghadasi SA, Wang J, McCann JL, Serebrenik AA, Ebrahimi D, Jarvis MC, Brown WL, Harris RS., Free PMC Article | 09/26/2020 |
| PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore. | PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore.
Smith RJ, Cordeiro MH, Davey NE, Vallardi G, Ciliberto A, Gross F, Saurin AT., Free PMC Article | 09/5/2020 |
| Studies indicate protein phosphatase 2, regulatory subunit B', alpha isoform protein (PPP2R5A) plays an important role in many cellular activities. | PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development.
Mao Z, Liu C, Lin X, Sun B, Su C. | 10/27/2018 |
| Overexpression of miR-218 led to inhibition of PPP2R5A expression, whereas knockdown of miR-218 increased PPP2R5A levels. Introduction of PPP2R5A abrogated miR218-mediated cell survival and drug resistance. | MicroRNA-218 promotes cisplatin resistance in oral cancer via the PPP2R5A/Wnt signaling pathway.
Zhuang Z, Hu F, Hu J, Wang C, Hou J, Yu Z, Wang TT, Liu X, Huang H., Free PMC Article | 05/5/2018 |
| A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2A(B56), modulates APC/C(Cdc20) assembly. | The PP2A(B56) phosphatase promotes the association of Cdc20 with APC/C in mitosis.
Lee SJ, Rodriguez-Bravo V, Kim H, Datta S, Foley EA., Free PMC Article | 02/24/2018 |
| Results report that BubR1 and RepoMan bind directly to PP2A-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser residue enhances binding. RepoMan and BubR1 bind B56 using both hydrophobic and electrostatic interactions. | Expanding the PP2A Interactome by Defining a B56-Specific SLiM.
Wang X, Bajaj R, Bollen M, Peti W, Page R., Free PMC Article | 07/1/2017 |
| cyclin E is specifically dephosphorylated at S384 by the PP2A-B56 phosphatase, thereby uncoupling cyclin E degradation from cyclin E-CDK2 activity | The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation.
Davis RJ, Swanger J, Hughes BT, Clurman BE., Free PMC Article | 07/1/2017 |
| structure of the PP2A B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A to specific targets. | Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.
Wang J, Wang Z, Yu T, Yang H, Virshup DM, Kops GJ, Lee SH, Zhou W, Li X, Xu W, Rao Z., Free PMC Article | 06/10/2017 |
| results suggest that PKCalpha can modify PP2A activity by phosphorylation of B56alpha at Ser(41). This interplay between PKCalpha and PP2A represents a new mechanism to regulate important cellular functions like cellular Ca(2+) homeostasis. | Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41.
Kirchhefer U, Heinick A, König S, Kristensen T, Müller FU, Seidl MD, Boknik P., Free PMC Article | 03/22/2014 |
| PP2A regulatory subunit Balpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. | PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.
Martin M, Geudens I, Bruyr J, Potente M, Bleuart A, Lebrun M, Simonis N, Deroanne C, Twizere JC, Soubeyran P, Peixoto P, Mottet D, Janssens V, Hofmann WK, Claes F, Carmeliet P, Kettmann R, Gerhardt H, Dequiedt F., Free PMC Article | 11/16/2013 |
| Following TGF-beta1 treatment, recruitment of PP2A-Balpha by TbetaRI increased in benign cells, but not in malignant cells. Inhibition of PP2A in benign cells resulted in an increase in ERK activation and in TGF-beta1 auto-induction after TGF-beta1 treatment. | Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor.
Yu N, Kozlowski JM, Park II, Chen L, Zhang Q, Xu D, Doll JA, Crawford SE, Brendler CB, Lee C., Free PMC Article | 11/24/2012 |
| reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling. | The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1.
Jin Z, Mei W, Strack S, Jia J, Yang J., Free PMC Article | 12/10/2011 |
| Reveal that PPP2R5A, an essential tumour suppressor, tunes the balance of phosphorylation to promote chromosome-spindle interactions during cell division. | Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.
Foley EA, Maldonado M, Kapoor TM., Free PMC Article | 12/10/2011 |
| The PP2A-B'alpha holoenzyme appears to function as an important endogenous regulator of SK1. | A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1.
Pitman MR, Barr RK, Gliddon BL, Magarey AM, Moretti PA, Pitson SM. | 05/21/2011 |
| B56alpha has a role in nuclear export of the catalytic subunit of PP2A | Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit.
Flegg CP, Sharma M, Medina-Palazon C, Jamieson C, Galea M, Brocardo MG, Mills K, Henderson BR., Free PMC Article | 07/5/2010 |
| The B'alpha subunit of protein phosphatase 2A (PP 2A) as a CHK2 binding partner shows that their interaction is modulated by DNA damage. | Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage.
Freeman AK, Dapic V, Monteiro AN., Free PMC Article | 06/14/2010 |
| these data indicate that the B subunits alpha and delta are essential for the interaction of PP2A with CaMKIV. | The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex.
Reece KM, Mazalouskas MD, Wadzinski BE., Free PMC Article | 01/21/2010 |
| The B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated. | Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A.
Li H, Okamoto K, Peart MJ, Prives C., Free PMC Article | 01/21/2010 |
| PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells. | PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells.
Ruvolo VR, Kurinna SM, Karanjeet KB, Schuster TF, Martelli AM, McCubrey JA, Ruvolo PP., Free PMC Article | 01/21/2010 |