| The PP2A regulator IER5L supports prostate cancer progression. | The PP2A regulator IER5L supports prostate cancer progression.
Crespo JR, Martín-Martín N, Garcia-Longarte S, Corres-Mendizabal J, Carlevaris O, Astobiza I, Zabala-Letona A, Guiu M, Azkargorta M, Gonzalez-Lopez M, Macías-Cámara N, Doan P, Elortza F, Mendizabal I, Westermack J, Gomis RR, Ercilla A, Carracedo A., Free PMC Article | 08/19/2024 |
| FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55alpha/PP2A through helical motifs. | FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs.
Wasserman JS, Faezov B, Patel KR, Kurimchak AM, Palacio SM, Glass DJ, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL Jr, Graña X., Free PMC Article | 08/2/2024 |
| The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction. | The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.
Ando S, Tanaka K, Matsumoto M, Oyama Y, Tomabechi Y, Yamagata A, Shirouzu M, Nakagawa R, Okimoto N, Taiji M, Sato K, Ohama T., Free PMC Article | 06/6/2024 |
| Structural characterization of methylation-independent PP2A assembly guides alphafold2Multimer prediction of family-wide PP2A complexes. | Structural characterization of methylation-independent PP2A assembly guides alphafold2Multimer prediction of family-wide PP2A complexes.
Wachter F, Nowak RP, Ficarro S, Marto J, Fischer ES., Free PMC Article | 06/6/2024 |
| PR55alpha-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by gamma-irradiation. | PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.
Palanivel C, Madduri LSV, Hein AL, Jenkins CB, Graff BT, Camero AL, Zhou S, Enke CA, Ouellette MM, Yan Y., Free PMC Article | 03/22/2024 |
| PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells. | PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells.
Kohyanagi N, Kitamura N, Ikeda S, Shibutani S, Sato K, Ohama T., Free PMC Article | 02/13/2024 |
| PP2A drives the stemness in colorectal cancer cells by decreasing the Hippo signaling pathway. | PP2A drives the stemness in colorectal cancer cells by decreasing the Hippo signaling pathway.
Wang M, Chen T, Zhang J, Wen X. | 02/1/2024 |
| PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via spindle assembly checkpoint reactivation. | PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via spindle assembly checkpoint reactivation.
Wang J, Chen Y, Li S, Liu W, Zhou XA, Luo Y, Xu Z, Xiong Y, Cheng K, Ruan M, Yu W, Li X, Wang W, Wang J., Free PMC Article | 01/8/2024 |
| PTPA variants are rare in early-onset and familial Parkinson's disease. | PTPA variants are rare in early-onset and familial Parkinson's disease.
Dulski J, Soto-Beasley AI, Uitti RJ, Wszolek ZK, Ross OA. | 12/5/2023 |
| Regulation and role of the PP2A-B56 holoenzyme family in cancer. | Regulation and role of the PP2A-B56 holoenzyme family in cancer.
Peris I, Romero-Murillo S, Vicente C, Narla G, Odero MD. | 09/11/2023 |
| Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance. | Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
Rasool RU, O'Connor CM, Das CK, Alhusayan M, Verma BK, Islam S, Frohner IE, Deng Q, Mitchell-Velasquez E, Sangodkar J, Ahmed A, Linauer S, Mudrak I, Rainey J, Zawacki KP, Suhan TK, Callahan CG, Rebernick R, Natesan R, Siddiqui J, Sauter G, Thomas D, Wang S, Taylor DJ, Simon R, Cieslik M, Chinnaiyan AM, Busino L, Ogris E, Narla G, Asangani IA., Free PMC Article | 09/6/2023 |
| Protein phosphatase 2A propels follicular T helper cell development in lupus. | Protein phosphatase 2A propels follicular T helper cell development in lupus.
Jiang Y, Jin X, Chi Z, Bai Y, Manthiram K, Mudd P, Zhu K, Wang L, Schwartzberg PL, Han Y, Gao X, Lu L, Xu Q., Free PMC Article | 08/10/2023 |
| Cross-Ethnic Variant Screening and Burden Analysis of PTPA in Parkinson's Disease. | Cross-Ethnic Variant Screening and Burden Analysis of PTPA in Parkinson's Disease.
Li C, Lin J, Jiang Q, Yang T, Xiao Y, Huang J, Hou Y, Wei Q, Cui Y, Wang S, Xiaoting Z, Ou R, Liu K, Chen X, Song W, Zhao B, Shang H. | 07/31/2023 |
| PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis. | PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
Jayappa KD, Tran B, Gordon VL, Morris C, Saha S, Farrington CC, O'Connor CM, Zawacki KP, Isaac KM, Kester M, Bender TP, Williams ME, Portell CA, Weber MJ, Narla G., Free PMC Article | 07/7/2023 |
| Clinical, neuroimaging and molecular characteristics of PPP2R5D-related neurodevelopmental disorders: an expanded series with functional characterisation and genotype-phenotype analysis. | Clinical, neuroimaging and molecular characteristics of PPP2R5D-related neurodevelopmental disorders: an expanded series with functional characterisation and genotype-phenotype analysis.
Oyama N, Vaneynde P, Reynhout S, Pao EM, Timms A, Fan X, Foss K, Derua R, Janssens V, Chung W, Mirzaa GM. | 04/26/2023 |
| PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability. | PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability.
Fevga C, Tesson C, Carreras Mascaro A, Courtin T, van Coller R, Sakka S, Ferraro F, Farhat N, Bardien S, Damak M, Carr J, Ferrien M, Boumeester V, Hundscheid J, Grillenzoni N, Kessissoglou IA, Kuipers DJS, Quadri M, French and Mediterranean Parkinson disease Genetics Study Group, International Parkinsonism Genetics Network, Corvol JC, Mhiri C, Hassan BA, Breedveld GJ, Lesage S, Mandemakers W, Brice A, Bonifati V., Free PMC Article | 04/24/2023 |
| Structural mechanism for inhibition of PP2A-B56alpha and oncogenicity by CIP2A. | Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
Pavic K, Gupta N, Omella JD, Derua R, Aakula A, Huhtaniemi R, Määttä JA, Höfflin N, Okkeri J, Wang Z, Kauko O, Varjus R, Honkanen H, Abankwa D, Köhn M, Hytönen VP, Xu W, Nilsson J, Page R, Janssens V, Leitner A, Westermarck J., Free PMC Article | 03/24/2023 |
| Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates. | Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates.
Fu Y, Jia X, Yuan J, Yang Y, Zhang T, Yu Q, Zhou J, Wang T. | 03/21/2023 |
| Hsa-miR-409-3p regulates endothelial progenitor senescence via PP2A-P38 and is a potential ageing marker in humans. | Hsa-miR-409-3p regulates endothelial progenitor senescence via PP2A-P38 and is a potential ageing marker in humans.
Lee YN, Wu YJ, Lee HI, Wang HH, Hung CL, Chang CY, Chou YH, Tien TY, Lee CW, Lin CF, Su CH, Yeh HI., Free PMC Article | 03/7/2023 |
| Protein Phosphatase 2a Inhibits Gastric Cancer Cell Glycolysis by Reducing MYC Signaling. | Protein Phosphatase 2a Inhibits Gastric Cancer Cell Glycolysis by Reducing MYC Signaling.
Cai Z, Zhang W, Zhou R, Wang Y, Feng Y. | 02/23/2023 |
| PP2A-B55 and its adapter proteins IER2 and IER5 regulate the activity of RB family proteins and the expression of cell cycle-related genes. | PP2A-B55 and its adapter proteins IER2 and IER5 regulate the activity of RB family proteins and the expression of cell cycle-related genes.
Doi K, Takeuchi H, Sakurai H. | 02/11/2023 |
| ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II. | ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II.
Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M., Free PMC Article | 12/17/2022 |
| A functional interaction between liprin-alpha1 and B56gamma regulatory subunit of protein phosphatase 2A supports tumor cell motility. | A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility.
Ripamonti M, Lamarca A, Davey NE, Tonoli D, Surini S, de Curtis I., Free PMC Article | 10/8/2022 |
| NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity. | NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity.
Wang Y, Zhou X, Lei Y, Chu Y, Yu X, Tong Q, Zhu T, Yu H, Fang S, Li G, Wang L, Wang GY, Xie X, Zhang J. | 09/24/2022 |
| A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation. | A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation.
Sontag JM, Schuhmacher D, Taleski G, Jordan A, Khan S, Hoffman A, Gomez RJ, Mazalouskas MD, Hanks SK, Spiller BW, Sontag E, Wadzinski BE., Free PMC Article | 09/17/2022 |