| CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway. | CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.
Yang P, Zhang D, Wang T, Ji J, Jin C, Peng C, Tan Y, Zhou J, Wang L, Feng Y, Sun Y., Free PMC Article | 10/1/2022 |
| Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway. | Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.
Jin J, Zhang L, Li X, Xu W, Yang S, Song J, Zhang W, Zhan J, Luo J, Zhang H., Free PMC Article | 05/14/2022 |
| Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression. | Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression.
Meng L, Chang S, Sang Y, Ding P, Wang L, Nan X, Xu R, Liu F, Gu L, Zheng Y, Li Z, Sang M., Free PMC Article | 03/19/2022 |
| RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. | RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.
Yang H, Hu J, Chen J, Chen Z, Jiao F, Cui J, Quan M, Wang L. | 12/12/2020 |
| The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. | The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
Lee PC, Beyrakhova K, Xu C, Boniecki MT, Lee MH, Onu CJ, Grishin AM, Machner MP, Cygler M., Free PMC Article | 08/29/2020 |
| validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 and Mob1a. | A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Kumar P, Munnangi P, Chowdary KR, Shah VJ, Shinde SR, Kolli NR, Halehalli RR, Nagarajaram HA, Maddika S., Free PMC Article | 05/19/2018 |
| In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases. | MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC., Free PMC Article | 03/24/2018 |
| Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A regulates its interaction with both MST kinases and LATS/NDR family kinases in vitro. | Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.
Xiong S, Couzens AL, Kean MJ, Mao DY, Guettler S, Kurinov I, Gingras AC, Sicheri F., Free PMC Article | 03/24/2018 |
| MOB1 binds differently to the NDR2 and LATS1 kinases.MOB1 interaction with Hippo and MST protein is not essential for development and tissue growth control. | Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
Kulaberoglu Y, Lin K, Holder M, Gai Z, Gomez M, Assefa Shifa B, Mavis M, Hoa L, Sharif AAD, Lujan C, Smith ESJ, Bjedov I, Tapon N, Wu G, Hergovich A., Free PMC Article | 01/20/2018 |
| No relationship has been found between the MOBKL1B-NS5A interaction and hepatitis C virus replication. | Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction.
Chung HY, Gu M, Buehler E, MacDonald MR, Rice CM., Free PMC Article | 11/22/2014 |
| The RING ligase praja2 ubiquitylates and degrades Mob, a core component of NDR/LATS kinase and a positive regulator of the tumour-suppressor Hippo cascade. | Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.
Lignitto L, Arcella A, Sepe M, Rinaldi L, Delle Donne R, Gallo A, Stefan E, Bachmann VA, Oliva MA, Tiziana Storlazzi C, L'Abbate A, Brunetti A, Gargiulo S, Gramanzini M, Insabato L, Garbi C, Gottesman ME, Feliciello A., Free PMC Article | 01/4/2014 |
| Mob1A and Mob1B are needed for cell abscission and centriole re-joining after telophase and cytokinesis. | Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.
Florindo C, Perdigão J, Fesquet D, Schiebel E, Pines J, Tavares AA. | 01/26/2013 |
| Results suggest that Mob1 and the other mammalian orthologues of the mitotic exit network regulate mitotic progression by facilitating the timely mobilization of the chromosomal passenger complex to the spindle midzone. | Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis.
Wilmeth LJ, Shrestha S, Montaño G, Rashe J, Shuster CB., Free PMC Article | 04/19/2010 |
| hMOB1A and hMOB1B are 2 LATS-binding proteins that may function as tumor suppressors in human cancer cells. | Molecular characterization of human homologs of yeast MOB1.
Chow A, Hao Y, Yang X. | 03/29/2010 |
| MATS1 mRNA expression is suppressed in tumor tissue and its low expression is associated with tumor growth, invasion and metastasis of colorectal cancer | Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer.
Kosaka Y, Mimori K, Tanaka F, Inoue H, Watanabe M, Mori M. | 01/21/2010 |
| Mats1 can rescue the lethality associated with loss of Mats function in Drosophila; As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans | Control of cell proliferation and apoptosis by mob as tumor suppressor, mats.
Lai ZC, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, Ho LL, Li Y. | 01/21/2010 |