| Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders. | Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders.
Auvinen P, Vehviläinen J, Marjonen H, Modhukur V, Sokka J, Wallén E, Rämö K, Ahola L, Salumets A, Otonkoski T, Skottman H, Ollikainen M, Trokovic R, Kahila H, Kaminen-Ahola N., Free PMC Article | 01/11/2023 |
| Dynamic cytosolic foci of DPPA4 in human pluripotent stem cells. | Dynamic cytosolic foci of DPPA4 in human pluripotent stem cells.
Abu-Dawud R, Mistry BV, Almahdali R, Matin MM, Alaiya A, Alghamdi F, Alamari H, Al-Yacoub N, Kashir J, Houssein M, Alawad A, Andrews PW, Assiri AM. | 10/1/2022 |
| Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region. | Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
Li H, Long C, Xiang J, Liang P, Li X, Zuo Y. | 11/22/2021 |
| Dppa4 promotes nonsmallcell lung cancer progression, partly through glycolysis by lactate dehydrogenase B. | High developmental pluripotency‑associated 4 expression promotes cell proliferation and glycolysis, and predicts poor prognosis in non‑small‑cell lung cancer.
Li L, Wang Y, Wang Q, Qu J, Wei X, Xu J, Wang Y, Suo F, Zhang Y., Free PMC Article | 12/21/2019 |
| identifies EBP1 as a novel pluripotency cofactor and provides insight into potential mechanisms used by DPPA4 in regulating pluripotency through its association with EBP1 | ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells.
Somanath P, Bush KM, Knoepfler PS., Free PMC Article | 04/20/2019 |
| Across cell types Dppa4 shows a preference for binding to regions with active chromatin signatures, and can influence chromatin modifications at target genes. Data provide novel insights into Dppa4 function in both pluripotent and oncogenic contexts. | Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer.
Klein RH, Tung PY, Somanath P, Fehling HJ, Knoepfler PS., Free PMC Article | 03/30/2019 |
| knockdown of PCGF1 results in reduced expression of DPPA4 and other subunits of the variant PRC1 complex at both mRNA and protein levels | The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
Oliviero G, Munawar N, Watson A, Streubel G, Manning G, Bardwell V, Bracken AP, Cagney G., Free PMC Article | 10/22/2016 |
| Results identified a new family of pluripotency-related oncogenes consisting of DPPA2 and DPPA4. | Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes.
Tung PY, Varlakhanova NV, Knoepfler PS., Free PMC Article | 09/20/2014 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Thsi study identifies DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays. | Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.
Chakravarthy H, Boer B, Desler M, Mallanna SK, McKeithan TW, Rizzino A. | 01/21/2010 |