| Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192. | Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
Guo J, He WB, Dai L, Tian F, Luo Z, Shen F, Tu M, Zheng Y, Zhao L, Tan C, Guo Y, Meng LL, Liu W, Deng M, Wu X, Peng Y, Zhang S, Lu GX, Lin G, Wang H, Tan YQ, Yang Y., Free PMC Article | 01/17/2024 |
| CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma. | CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.
Liu Y, Liang W, Chang Y, He Z, Wu M, Zheng H, Ke X, Lv M, Liu Q, Liu Q, Tang W, Huang Q, Lu Y, He M, Yang Q, Mo C, Wang J, Peng K, Min Z, Su H, Chen J., Free PMC Article | 10/22/2022 |
| Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly. | Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.
Chinen T, Yamazaki K, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D, Kitagawa D., Free PMC Article | 09/4/2021 |
| Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease. | Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.
Cai C, Song X, Yu C., Free PMC Article | 06/12/2021 |
| induced FBXL13 expression downregulates centrosomal gamma-tubulin and disrupts centrosomal microtubule arrays. In addition, depletion of FBXL13 induces high levels of CEP192 and gamma-tubulin at the centrosomes with the consequence of defects in cell motility. | FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
Fung E, Richter C, Yang HB, Schäffer I, Fischer R, Kessler BM, Bassermann F, D'Angiolella V., Free PMC Article | 02/9/2019 |
| Study shows that the interaction between Cep295 and Cep192 seems to be crucial for the integrity of centriole structure and also for daughter-to-mother centriole conversion. | Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.
Tsuchiya Y, Yoshiba S, Gupta A, Watanabe K, Kitagawa D., Free PMC Article | 09/22/2018 |
| Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. | Recruitment of PP1 to the centrosomal scaffold protein CEP192.
Nasa I, Trinkle-Mulcahy L, Douglas P, Chaudhuri S, Lees-Miller SP, Lee KS, Moorhead GB., Free PMC Article | 06/10/2017 |
| Interphase cells depleted of Cep192 display significantly higher levels of centrosome-associated Pericentrin while overexpression of Cep192 reduces the levels of centrosomal Pericentrin. | Cep192 controls the balance of centrosome and non-centrosomal microtubules during interphase.
O'Rourke BP, Gomez-Ferreria MA, Berk RH, Hackl AM, Nicholas MP, O'Rourke SC, Pelletier L, Sharp DJ., Free PMC Article | 10/31/2015 |
| Plk1 promotes centrosome-based bipolar spindle formation by forming two functionally nonredundant complexes with Cep192. | Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation.
Meng L, Park JE, Kim TS, Lee EH, Park SY, Zhou M, Bang JK, Lee KS., Free PMC Article | 10/3/2015 |
| Study identifies a Cep192-organized signaling cascade that underlies both centrosome maturation and bipolar spindle assembly. | The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.
Joukov V, Walter JC, De Nicolo A., Free PMC Article | 10/25/2014 |
| Plk4 is intricately regulated in time and space through ordered interactions with two distinct scaffolds, Cep192 and Cep152, and a failure in this process may lead to human cancer. | Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
Park SY, Park JE, Kim TS, Kim JH, Kwak MJ, Ku B, Tian L, Murugan RN, Ahn M, Komiya S, Hojo H, Kim NH, Kim BY, Bang JK, Erikson RL, Lee KW, Kim SJ, Oh BH, Yang W, Lee KS., Free PMC Article | 10/11/2014 |
| Loss of the Cep192- or Cep152-dependent interaction with Plk4 resulted in impaired centriole duplication that led to delayed cell proliferation. | Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.
Kim TS, Park JE, Shukla A, Choi S, Murugan RN, Lee JH, Ahn M, Rhee K, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS., Free PMC Article | 02/22/2014 |
| cooperation between Cep192 and Cep152 is crucial for centriole recruitment of Plk4 and centriole duplication during the cell cycle. | Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
Sonnen KF, Gabryjonczyk AM, Anselm E, Stierhof YD, Nigg EA. | 11/30/2013 |
| By modulating Cep192 levels, PHD1 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression. | PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.
Moser SC, Bensaddek D, Ortmann B, Maure JF, Mudie S, Blow JJ, Lamond AI, Swedlow JR, Rocha S., Free PMC Article | 11/30/2013 |
| CEP192 promotes robust mitotic spindle assembly by regulating K63-polyubiquitin-mediated signaling through CYLD. | CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly.
Gomez-Ferreria MA, Bashkurov M, Mullin M, Gingras AC, Pelletier L., Free PMC Article | 03/2/2013 |
| Cep192-mediated mechanism maximizes AurA activity at centrosomes and appears essential for the function of these organelles as primary microtubule -organizing centers. | Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation.
Joukov V, De Nicolo A, Rodriguez A, Walter JC, Livingston DM., Free PMC Article | 02/5/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells | The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.
Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Müller-Reichert T, Kittler R, Hyman AA, Pelletier L. | 01/21/2010 |
| Cep192 stimulates the formation of the scaffolding upon which gamma-tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis. | Human Cep192 is required for mitotic centrosome and spindle assembly.
Gomez-Ferreria MA, Rath U, Buster DW, Chanda SK, Caldwell JS, Rines DR, Sharp DJ. | 01/21/2010 |