| USP47 stabilizes YBX1 to promote the progression of acute myeloid leukemia. | USP47 stabilizes YBX1 to promote the progression of acute myeloid leukemia.
Lei H, Xu H, Yang L, Wang Y, Zhang Y, Wu Y. | 02/15/2024 |
| USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis. | USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis.
Wang A, Huang H, Shi JH, Yu X, Ding R, Zhang Y, Han Q, Ni ZY, Li X, Zhao R, Zou Q., Free PMC Article | 12/5/2023 |
| Structural and functional characterization of USP47 reveals a hot spot for inhibitor design. | Structural and functional characterization of USP47 reveals a hot spot for inhibitor design.
Shin SC, Park J, Kim KH, Yoon JM, Cho J, Ha BH, Oh Y, Choo H, Song EJ, Kim EE., Free PMC Article | 09/28/2023 |
| Deubiquitinase USP47 attenuates virus-induced type I interferon signaling. | Deubiquitinase USP47 attenuates virus-induced type I interferon signaling.
Chen HY, Tang RC, Liang JW, Zhao W, Yu SS, Yao RR, Xu R, Zhang A, Geng S, Sun XY, Ge Q, Zhang J. | 04/26/2023 |
| USP47 deubiquitylates Groucho/TLE to promote Wnt-beta-catenin signaling. | USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.
Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, Robbins DJ, Thorne CA, Ahmed Y, Lee E., Free PMC Article | 02/13/2023 |
| Ubiquitin specific peptidase 47 promotes proliferation of lung squamous cell carcinoma. | Ubiquitin specific peptidase 47 promotes proliferation of lung squamous cell carcinoma.
Yu L, Fu J, Shen C. | 07/30/2022 |
| USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide. | USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide.
Zhang S, Ju X, Yang Q, Zhu Y, Fan D, Su G, Kong L, Li Y. | 09/11/2021 |
| Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis. | Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis.
Gregory JM, McDade K, Livesey MR, Croy I, Marion de Proce S, Aitman T, Chandran S, Smith C. | 08/28/2021 |
| Proteomics analysis reveals the role of ubiquitin specific protease (USP47) in Epithelial to Mesenchymal Transition (EMT) induced by TGFbeta2 in breast cells. | Proteomics analysis reveals the role of ubiquitin specific protease (USP47) in Epithelial to Mesenchymal Transition (EMT) induced by TGFβ2 in breast cells.
Silvestrini VC, Thomé CH, Albuquerque D, de Souza Palma C, Ferreira GA, Lanfredi GP, Masson AP, Delsin LEA, Ferreira FU, de Souza FC, de Godoy LMF, Aquino A, Carrilho E, Panepucci RA, Covas DT, Faça VM. | 07/31/2021 |
| Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression. | Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression.
Zhang S, Ding L, Gao F, Fan H. | 05/22/2021 |
| Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia. | Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, Gao FH, Xia L, Yang L, Liu LG, Wang WW, Liu CX, Tong Y, Wu YZ, Zheng JK, Chen GQ, Zhou L, Wu YL., Free PMC Article | 01/16/2021 |
| USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer. | USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer.
Pan B, Yang Y, Li J, Wang Y, Fang C, Yu FX, Xu Y., Free PMC Article | 12/5/2020 |
| lncRNA LINC00668 acted as an oncogenic role in CRC cells by sponging miR-188-5p and upregulating USP47 | LINC00668 promotes tumorigenesis and progression through sponging miR-188-5p and regulating USP47 in colorectal cancer.
Yan S, Yue Y, Wang J, Li W, Sun M, Gu C, Zeng L. | 01/4/2020 |
| These results demonstrate, for the first time, the role for USP47, as a novel target of Sox9, in the regulation of epithelial-mesenchymal transition and metastasis of colorectal cancer cells. | Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9.
Choi BJ, Park SA, Lee SY, Cha YN, Surh YJ., Free PMC Article | 07/13/2019 |
| these data reveal a new post-transcriptional role for USP47 and USP7 in inflammation by regulating inflammasome activation and the release of the pro-inflammatory cytokines IL-1beta and IL-18, and implicate dual USP7 and USP47 inhibitors as potential therapeutic agents for inflammatory disease. | USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation.
Palazón-Riquelme P, Worboys JD, Green J, Valera A, Martín-Sánchez F, Pellegrini C, Brough D, López-Castejón G., Free PMC Article | 06/8/2019 |
| these results suggest that USP47 may play distinct roles in ubiquitin-mediated cellular processes via de-ubiquitinating enzymes activity. | Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.
Piao J, Tashiro A, Nishikawa M, Aoki Y, Moriyoshi E, Hattori A, Kakeya H. | 08/13/2016 |
| miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A. | MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A.
Zhang B, Yin Y, Hu Y, Zhang J, Bian Z, Song M, Hua D, Huang Z. | 01/30/2016 |
| USP47 is a deubiquitinase that prevents beta-catenin ubiquitination. | Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.
Shi J, Liu Y, Xu X, Zhang W, Yu T, Jia J, Liu C., Free PMC Article | 12/5/2015 |
| Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47. | Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions.
Sako-Kubota K, Tanaka N, Nagae S, Meng W, Takeichi M., Free PMC Article | 08/1/2015 |
| The results of this study indicated that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. | USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth.
Yang SW, Oh KH, Park E, Chang HM, Park JM, Seong MW, Ka SH, Song WK, Park DE, Baas PW, Jeon YJ, Chung CH., Free PMC Article | 10/19/2013 |
| USP47 has a role in regulating DNA repair and maintaining genome integrity | USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
Parsons JL, Dianova II, Khoronenkova SV, Edelmann MJ, Kessler BM, Dianov GL. | 05/7/2011 |
| USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies. | The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.
Peschiaroli A, Skaar JR, Pagano M, Melino G., Free PMC Article | 05/3/2010 |