| PID1 reduces serum HDL-Cholesterol levels. | Overexpression of PID1 reduces high density lipoprotein level and functionality in swine.
Mu Q, Zhu J, Si Y, Chen X, Duan G, Sun S, Fang G, Zeng Y, Yang N. | 07/11/2020 |
| By acting as an insulin-dependent retention adaptor, PID1 serves as a regulator of LRP1 function controlling the disposal of postprandial lipoproteins. | The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.
Fischer AW, Albers K, Krott LM, Hoffzimmer B, Heine M, Schmale H, Scheja L, Gordts PLSM, Heeren J., Free PMC Article | 10/19/2019 |
| Overall survival and radiation-free progression-free survival were longer in medulloblastoma patients whose tumors had higher PID1 mRNA levels. | PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
Erdreich-Epstein A, Robison N, Ren X, Zhou H, Xu J, Davidson TB, Schur M, Gilles FH, Ji L, Malvar J, Shackleford GM, Margol AS, Krieger MD, Judkins AR, Jones DT, Pfister SM, Kool M, Sposto R, Asgharzadeh S., Free PMC Article | 10/18/2014 |
| overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4-overexpressing adipocytes | Overexpression of TFAM protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance and mitochondrial dysfunction.
Shi CM, Xu GF, Yang L, Fu ZY, Chen L, Fu HL, Shen YH, Zhu L, Ji CB, Guo XR. | 03/8/2014 |
| NYGGF4 plays a role in IR and its effects on IR could be reversed by metformin through activating IRS-1/PI3K/Akt and AMPK-PGC1-alpha pathways. | NYGGF4 (PID1) effects on insulin resistance are reversed by metformin in 3T3-L1 adipocytes.
Qiu J, Wang YM, Shi CM, Yue HN, Qin ZY, Zhu GZ, Cao XG, Ji CB, Cui Y, Guo XR. | 05/4/2013 |
| NYGGF4 acts directly on the IRS1/PI3K/AKT insulin pathway to reduce glucose uptake and transport, impairs mitochondrial function and causes insulin resistance, and thus may be a useful therapeutic target for obesity-associated insulin resistance. | NYGGF4 as a new therapeutic target for obesity-associated insulin resistance.
Yu Z, Guo X. | 06/30/2012 |
| Overexpression of NYGGF4 caused mitochondrial dysfunction in adipocytes, which might be responsible for the development of NYGGF4-induced insulin resistance. | Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes.
Zhao Y, Zhang C, Chen X, Gao C, Ji C, Chen F, Zhu C, Zhu J, Wang J, Qian L, Guo X. | 09/27/2010 |
| TNFA up-regulated the expression of NYGGF4 during preadipocyte differentiation. | [Expression of the NYGGF4 gene during human preadipocyte differentiation and the regulative role of tumor necrosis factor-alpha].
Zhao Y, Wang J, Cai Y, Chen X, Zhang C, Guo X. | 05/31/2010 |
| NYGGF4 over-expression impairs the insulin sensitivity of 3T3-L1 adipocytes through decreasing GLUT4 translocation and had no effects on the secretory function of adipocytes. | [Effects of NYGGF4 gene over-expression on the insulin sensitivity and secretory function of adipocytes].
Zhang CM, Qiu J, Chen XH, Wang B, Zhang M, Guo XR. | 03/15/2010 |
| Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) | Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter JI, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BH, O'Connor GT, London SJ., Free PMC Article | 01/20/2010 |
| Q7Z2X4 protein (PID1) identified as a cytosolic ligand of LRP1 in a trimeric complex with Cubilin. Q7Z2X4 named PCLI1 (PTB-containing, Cubilin and LRP1 Interacting protein 1) | Identification of the ligands of protein interaction domains through a functional approach.
Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N. | 12/9/2009 |
| Data show that NYGGF4 regulates the functions of IRS-1 and Akt, decreases GLUT4 translocation and reduces glucose uptake in response to insulin. | Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt.
Zhang CM, Chen XH, Wang B, Liu F, Chi X, Tong ML, Ni YH, Chen RH, Guo XR., Free PMC Article | 01/21/2010 |
| A novel gene named NYGGF4, which was expressed at a higher level in obese subjects, was isolated and characterized and could play a role in cell growth and adipogenesis process | Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation.
Wang B, Zhang M, Ni YH, Liu F, Fan HQ, Fei L, Pan XQ, Guo M, Chen RH, Guo XR. | 01/21/2010 |