| Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation. | Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation.
Shinoda S, Sakai Y, Matsui T, Uematsu M, Koyama-Honda I, Sakamaki JI, Yamamoto H, Mizushima N., Free PMC Article | 09/3/2024 |
| Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation. | Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation.
Cui X, Wang B, Han D, Cheng M, Yuan P, Du P, Hou Y, Su C, Tang J, Zhang J., Free PMC Article | 07/16/2024 |
| SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma. | SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.
Xu Y, Duan S, Ye W, Zheng Z, Zhang J, Gao Y, Ye S., Free PMC Article | 06/26/2024 |
| Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion. | Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion.
Zheng D, Tong M, Zhang S, Pan Y, Zhao Y, Zhong Q, Liu X. | 03/5/2024 |
| The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion. | The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
Jian F, Wang S, Tian R, Wang Y, Li C, Li Y, Wang S, Fang C, Ma C, Rong Y., | 02/6/2024 |
| ULK phosphorylation of STX17 controls autophagosome maturation via FLNA. | ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.
Wang Y, Que H, Li C, Wu Z, Jian F, Zhao Y, Tang H, Chen Y, Gao S, Wong CCL, Li Y, Zhao C, Rong Y., Free PMC Article | 07/5/2023 |
| Acetylation of STX17 (syntaxin 17) controls autophagosome maturation. | Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
Shen Q, Shi Y, Liu J, Su H, Huang J, Zhang Y, Peng C, Zhou T, Sun Q, Wan W, Liu W., Free PMC Article | 12/4/2021 |
| Long non-coding RNA XIST confers aggressive progression via miR-361-3p/STX17 in retinoblastoma cells. | Long non-coding RNA XIST confers aggressive progression via miR-361-3p/STX17 in retinoblastoma cells.
Yang LL, Li Q, Zhang X, Cao T. | 07/3/2021 |
| A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress. | A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
Arora K, Liyanage P, Zhong Q, Naren AP., Free PMC Article | 06/26/2021 |
| Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p. | Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p.
Liu H, Yuan HF, Xu D, Chen KJ, Tan N, Zheng QJ. | 06/26/2021 |
| DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B. | DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, Zhou X, Teng J, Chen J., Free PMC Article | 06/12/2021 |
| Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion. | Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
Li Y, Cheng X, Li M, Wang Y, Fu T, Zhou Z, Wang Y, Gong X, Xu X, Liu J, Pan L., Free PMC Article | 10/24/2020 |
| EACC affects the translocation of SNAREs Stx17 and SNAP29 on autophagosomes without impeding the completion of autophagosomes. EACC treatment also reduces the interaction of Stx17 with the HOPS subunit VPS33A and the cognate lysosomal R-SNARE VAMP8. | A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes.
Vats S, Manjithaya R., Free PMC Article | 06/13/2020 |
| Stx17 knockout diminished LC3 response and reduced sequestration of the prototypical bulk autophagy cargo lactate dehydrogenase. We conclude that Stx17 is a TBK1 substrate and that together they orchestrate assembly of mammalian pre-autophagosomal structure | Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation.
Kumar S, Gu Y, Abudu YP, Bruun JA, Jain A, Farzam F, Mudd M, Anonsen JH, Rusten TE, Kasof G, Ktistakis N, Lidke KA, Johansen T, Deretic V., Free PMC Article | 11/9/2019 |
| results reveal that the Stx17-PGAM5 axis plays pivotal roles in mitochondrial division and PINK1/Parkin-mediated mitophagy. | Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy.
Sugo M, Kimura H, Arasaki K, Amemiya T, Hirota N, Dohmae N, Imai Y, Inoshita T, Shiba-Fukushima K, Hattori N, Cheng J, Fujimoto T, Wakana Y, Inoue H, Tagaya M., Free PMC Article | 10/5/2019 |
| The cytotoxicity of coxsackievirus B3 is associated with a blockage of autophagic flux mediated by reduced STX17 expression. | The cytotoxicity of coxsackievirus B3 is associated with a blockage of autophagic flux mediated by reduced syntaxin 17 expression.
Tian L, Yang Y, Li C, Chen J, Li Z, Li X, Li S, Wu F, Hu Z, Yang Z., Free PMC Article | 09/14/2019 |
| Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3 | Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3.
Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, Tagaya M., Free PMC Article | 06/29/2019 |
| The kinase ULK1 and the apoptosis modulator BRUCE both regulate STX17 engagement during autophagosome maturation in mammalian cells. | Regulation of Syntaxin 17 during Autophagosome Maturation.
Viret C, Faure M. | 06/22/2019 |
| Study demonstrated that the STX17 initiates mitophagy upon depletion of outer mitochondrial membrane protein Fis1. Fis1 loss results in aberrant STX17 accumulation on mitochondria, which exposes the N terminus and promotes self-oligomerization to trigger mitophagy. Findings uncover a PINK1/Parkin-independent mitophagic mechanism in which outer mitochondrial membrane protein Fis1 regulates mitochondrial quality control. | STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism.
Xian H, Yang Q, Xiao L, Shen HM, Liou YC., Free PMC Article | 06/8/2019 |
| The Stx17 fusion competency is regulated by a phosphosite in its N-peptide, representing a previously unknown regulatory step in mammalian autophagy. | A VPS33A-binding motif on syntaxin 17 controls autophagy completion in mammalian cells.
Saleeb RS, Kavanagh DM, Dun AR, Dalgarno PA, Duncan RR., Free PMC Article | 06/1/2019 |
| MAP1B-LC1 links microtubules and Stx17 in fed cells, and starvation causes the dephosphorylation of MAP1B-LC1 at Thr217, allowing Stx17 to dissociate from MAP1B-LC1 and bind to Atg14L. | MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.
Arasaki K, Nagashima H, Kurosawa Y, Kimura H, Nishida N, Dohmae N, Yamamoto A, Yanagi S, Wakana Y, Inoue H, Tagaya M., Free PMC Article | 05/18/2019 |
| Stx17 directly interacts with IRGM, and efficient Stx17 recruitment to autophagosomes requires IRGM. Both IRGM and Stx17 directly interact with mammalian Atg8 proteins, thus being guided to autophagosomes. | Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.
Kumar S, Jain A, Farzam F, Jia J, Gu Y, Choi SW, Mudd MH, Claude-Taupin A, Wester MJ, Lidke KA, Rusten TE, Deretic V., Free PMC Article | 02/23/2019 |
| MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation. | MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation.
Huang J, Yang Y, Fang F, Liu K. | 12/22/2018 |
| L. pneumophila Lpg1137 can shut down ER-mitochondria communication through cleavage of syntaxin 17 | Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.
Arasaki K, Mikami Y, Shames SR, Inoue H, Wakana Y, Tagaya M., Free PMC Article | 12/22/2018 |
| SNARE priming, as exemplified by Syntaxin-17, is essential for maturation of autophagosomes but not for their formation. | SNARE priming is essential for maturation of autophagosomes but not for their formation.
Abada A, Levin-Zaidman S, Porat Z, Dadosh T, Elazar Z., Free PMC Article | 06/30/2018 |