| Circ_0090231 knockdown protects vascular smooth muscle cells from ox-LDL-induced proliferation, migration and invasion via miR-942-5p/PPM1B axis during atherosclerosis. | Circ_0090231 knockdown protects vascular smooth muscle cells from ox-LDL-induced proliferation, migration and invasion via miR-942-5p/PPM1B axis during atherosclerosis.
Yang J, Li X, Zhang Y, Che P, Qin W, Wu X, Liu Y, Hu B. | 08/26/2024 |
| RBM10 regulates the tumorigenic potential of human cancer cells by modulating PPM1B and YBX1 activities. | RBM10 regulates the tumorigenic potential of human cancer cells by modulating PPM1B and YBX1 activities.
Li Y, Wei D, Chen Z, Chen Y, Deng Y, Li M, Zhao Y, Niu K. | 02/21/2024 |
| Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-beta-induced breast cancer cell invasion and metastasis. | Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-β-induced breast cancer cell invasion and metastasis.
Du L, Li J, Tian Y, Feng R., Free PMC Article | 06/7/2023 |
| Protein Phosphatase PPM1B Inhibits Gastric Cancer Progression and Serves as a Favorable Prognostic Biomarker. | Protein Phosphatase PPM1B Inhibits Gastric Cancer Progression and Serves as a Favorable Prognostic Biomarker.
Li R, Dou J, Bai T, Cai B, Liu Y. | 05/14/2022 |
| [TRIM59 regulates invasion and migration of nasopharyngeal carcinoma cells by targeted modulation of PPM1B]. | [TRIM59 regulates invasion and migration of nasopharyngeal carcinoma cells by targeted modulation of PPM1B].
Wang W, Zhou L, Sun Z, Wu J, Cui Y., Free PMC Article | 09/18/2021 |
| Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation. | Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.
Lee YH, Im E, Hyun M, Park J, Chung KC., Free PMC Article | 08/28/2021 |
| Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx. | Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx.
Kakurina GV, Kolegova ES, Shashova EE, Velikaya VV, Startseva ZA, Cheremisina OV, Choinzonov EL, Kondakova IV. | 07/10/2021 |
| TRIM59 promotes tumor growth in hepatocellular carcinoma and regulates the cell cycle by degradation of protein phosphatase 1B. | TRIM59 promotes tumor growth in hepatocellular carcinoma and regulates the cell cycle by degradation of protein phosphatase 1B.
Ying H, Ji L, Xu Z, Fan X, Tong Y, Liu H, Zhao J, Cai X. | 10/10/2020 |
| Results indicate that protein phosphatase 1B (PPM1B) negatively regulates cancer cell motility and invasiveness through dephosphorylating Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1). | Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion.
Cho HJ, Kim JT, Lee SJ, Hwang YS, Park SY, Kim BY, Yoo J, Hong KS, Min JK, Lee CH, Lim JS, Yoon SR, Choi I, Choe YK, Lee HG. | 10/27/2018 |
| PPM1B plays a negative role in the activation of the p38-RB1-E2F1 pathway and that targeting PPM1B could be useful in certain types of cancer by stimulating chemotherapy-induced cell death. | PPM1B depletion in U2OS cells supresses cell growth through RB1-E2F1 pathway and stimulates bleomycin-induced cell death.
Miller RE, Uwamahoro N, Park JH. | 09/22/2018 |
| This study has identified PPM1B and miR-186 as potential diagnostic markers in bladder cancer. Promotion of PPM1B and suppression of miR-186 may offer effective therapeutic strategies in the treatment of bladder cancer. | miR-186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1-S phase transition.
Yang J, Yuan D, Li J, Zheng S, Wang B. | 02/4/2017 |
| PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. | The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.
Abraham S, Paknikar R, Bhumbra S, Luan D, Garg R, Dressler GR, Patel SR., Free PMC Article | 05/30/2015 |
| Results identify PPM1B as a critical regulator of both p38 MAPK-dependent and independent senescence pathways during normal cellular aging process. | PPM1B depletion induces premature senescence in human IMR-90 fibroblasts.
Park JH, Hale TK, Smith RJ, Yang T. | 04/11/2015 |
| Cadmium reversed PPM1A-induced cell cycle arrest and cadmium insensitive PPM1A mutant rescued cadmium induced cell death. | Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.
Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W, Sun JP., Free PMC Article | 02/15/2014 |
| Protein kinase A activates NF-kappaB-mediated transcription by destabilization of PP2Cbeta. | PKA negatively regulates PP2Cβ to activate NF-κB-mediated inflammatory signaling.
Choi HK, Park SY, Oh HJ, Han EJ, Lee YH, Lee J, Jun WJ, Choi KC, Yoon HG. | 09/14/2013 |
| the phosphatase PPM1B as a novel selective modulator of PPARgamma activity. | The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.
Tasdelen I, van Beekum O, Gorbenko O, Fleskens V, van den Broek NJ, Koppen A, Hamers N, Berger R, Coffer PJ, Brenkman AB, Kalkhoven E. | 05/4/2013 |
| PPM1B functions as a TBK1 phosphatase dephosphorylates TBK1 at serine 172 and terminates TBK1-mediated IRF3 activation and IFNbeta gene expression. | PPM1B negatively regulates antiviral response via dephosphorylating TBK1.
Zhao Y, Liang L, Fan Y, Sun S, An L, Shi Z, Cheng J, Jia W, Sun W, Mori-Akiyama Y, Zhang H, Fu S, Yang J., Free PMC Article | 01/12/2013 |
| Studies show that Ppm1b plays a multilayered role in regulating the availability and optimal activity of the EKLF protein in erythroid cells. | Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ.
Yien YY, Bieker JJ., Free PMC Article | 08/4/2012 |
| results implicate a novel and important role for PP2Cbetal in regulating hPXR activity and CYP3A4 expression by inhibiting or desensitizing signaling pathways that negatively regulate the function of pregnane X receptor in liver cells | Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.
Pondugula SR, Tong AA, Wu J, Cui J, Chen T., Free PMC Article | 01/8/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Protein phosphatase 1B is mediated dephosphorylation and inactivation of I-kappa B kinase as well as the termination of the Tumor Necrosis Factor-alpha-induced NF-kappaappaB activation. | PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
Sun W, Yu Y, Dotti G, Shen T, Tan X, Savoldo B, Pass AK, Chu M, Zhang D, Lu X, Fu S, Lin X, Yang J., Free PMC Article | 01/21/2010 |
| Overexpression of PPM1A and the related PPM1B greatly reduced Cdk9 T-loop phosphorylation | Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop.
Wang Y, Dow EC, Liang YY, Ramakrishnan R, Liu H, Sung TL, Lin X, Rice AP., Free PMC Article | 01/21/2010 |
| PP2Cbeta down-regulates cytokine-induced NF-kappaB activation by altering IKK activity. | Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.
Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB. | 01/21/2010 |