| During Shigella flexneri infection host protein Toca-1 precipitate not only the Shigella type 3 secreted effector protein IcsB, but also the type 3 secreted proteins OspC3, IpgD and IpaB. In infected cells, OspC3-mediated restriction of IL-18 production does not require the interaction with Toca-1. | Identification of interactions among host and bacterial proteins and evaluation of their role early during Shigella flexneri infection.
Miller KA, Garza-Mayers AC, Leung Y, Goldberg MB., Free PMC Article | 09/14/2019 |
| This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery. | Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.
Watson JR, Fox HM, Nietlispach D, Gallop JL, Owen D, Mott HR., Free PMC Article | 12/17/2016 |
| Loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease. | Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.
Chander H, Brien CD, Truesdell P, Watt K, Meens J, Schick C, Germain D, Craig AW., Free PMC Article | 11/14/2015 |
| GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence | Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.
Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ, Kirkpatrick RM, Cents RA, Franić S, Miller MB, Haworth CM, Meaburn E, Price TS, Evans DM, Timpson N, Kemp J, Ring S, McArdle W, Medland SE, Yang J, Harris SE, Liewald DC, Scheet P, Xiao X, Hudziak JJ, de Geus EJ, Wellcome Trust Case Control Consortium 2 (WTCCC2), Jaddoe VW, Starr JM, Verhulst FC, Pennell C, Tiemeier H, Iacono WG, Palmer LJ, Montgomery GW, Martin NG, Boomsma DI, Posthuma D, McGue M, Wright MJ, Davey Smith G, Deary IJ, Plomin R, Visscher PM., Free PMC Article | 10/4/2014 |
| findings suggest that Toca-1 functions at an early step in the dissemination of metastatic breast tumor cells; taken together, results identify Toca-1 as a proinvasive protein in breast adenocarcinoma | Transducer of Cdc42-dependent actin assembly promotes breast cancer invasion and metastasis.
Chander H, Truesdell P, Meens J, Craig AW. | 08/31/2013 |
| Toca-1 knockdown cells also display a significant defect in EGF-induced motility and invasiveness. | Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness.
Hu J, Mukhopadhyay A, Craig AW., Free PMC Article | 02/26/2011 |
| Cdc42 may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP complex. | Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis.
Bu W, Lim KB, Yu YH, Chou AM, Sudhaharan T, Ahmed S., Free PMC Article | 11/6/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| the Toca-1-N-WASP complex can link filopodial formation to endocytosis | The Toca-1-N-WASP complex links filopodial formation to endocytosis.
Bu W, Chou AM, Lim KB, Sudhaharan T, Ahmed S., Free PMC Article | 01/21/2010 |
| FNBP1L appears dispensable for other forms of autophagy induced by serum starvation or rapamycin | A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.
Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ, Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ., Free PMC Articles: PMC2752416, PMC2752416 | 01/21/2010 |
| Human FNBP1L binds the autophagy protein Atg3 and is required for autophagy of Salmonella Typhimurium in epithelial cells | A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.
Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ, Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ., Free PMC Articles: PMC2752416, PMC2752416 | 04/14/2009 |
| We show that actin tail initiation by S. flexneri requires Toca-1 for the conversion of N-WASP from a closed inactive conformation to an open active one. | Bacterial actin assembly requires toca-1 to relieve N-wasp autoinhibition.
Leung Y, Ally S, Goldberg MB., Free PMC Article | 01/21/2010 |
| a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP | Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination.
Kakimoto T, Katoh H, Negishi M. | 01/21/2010 |
| Toca-1 promotes actin nucleation by activating the N-WASP-WIP/CR16 complex, the predominant form of N-WASP in cells. | Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.
Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW. | 01/21/2010 |