| Elevations in the Mitochondrial Matrix Protein Cyclophilin D Correlate With Reduced Parvalbumin Expression in the Prefrontal Cortex of Patients With Schizophrenia. | Elevations in the Mitochondrial Matrix Protein Cyclophilin D Correlate With Reduced Parvalbumin Expression in the Prefrontal Cortex of Patients With Schizophrenia.
O'Brien JT, Jalilvand SP, Suji NA, Jupelly RK, Phensy A, Mwirigi JM, Elahi H, Price TJ, Kroener S., | 09/4/2024 |
| CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway. | CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway.
Fan H, Tian H, Jin F, Zhang X, Su S, Liu Y, Wen Z, He X, Li X, Duan C., Free PMC Article | 10/30/2023 |
| Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration? | Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?
Coluccino G, Muraca VP, Corazza A, Lippe G., Free PMC Article | 08/30/2023 |
| Cyclophilin D-mediated Mitochondrial Permeability Transition Regulates Mitochondrial Function. | Cyclophilin D-mediated Mitochondrial Permeability Transition Regulates Mitochondrial Function.
Zhou S, Yu Q, Zhang L, Jiang Z. | 05/30/2023 |
| These findings provided novel insights into the role of a CypD-dependent mitochondrial pathway. | Blockade of Cyclophilin D Attenuates Oxidative Stress-Induced Cell Death in Human Dental Pulp Cells.
Huang S, Zheng B, Jin X, Yu Q, Zhang X, Sun X, Chen Y, Ren X, Wismeijer D, Ma J, Zhang C, Wu G, Pan Y., Free PMC Article | 12/21/2019 |
| Data show that cyclophilin 40 (CyP40) interacts with and dissolves amyloids forming proteins tau and alpha-synuclein aggregates. | Human cyclophilin 40 unravels neurotoxic amyloids.
Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, Zweckstetter M, Dickey CA, Koren J 3rd, Blair LJ., Free PMC Article | 10/7/2017 |
| The thermodynamics of binding of Cyp-40 to Hsp90 shows remarkable temperature sensitivity in the physiological temperature range. | Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90.
Blackburn EA, Wear MA, Landré V, Narayan V, Ning J, Erman B, Ball KL, Walkinshaw MD., Free PMC Article | 06/28/2016 |
| cyclophilin-D protein could increase oxidative stress and cause endothelial cell injury and apoptosis. cyclophilin-D protein is the key factor in reactive oxygen species-induced mitochondrial damage, leading to apoptosis of endothelial cells. | Influence of cyclophilin D protein expression level on endothelial cell oxidative damage resistance.
Peng JZ, Xue L, Chen J, Chen BS, Yang YQ. | 02/20/2016 |
| Cyp40 binds to C2I in vitro and in intact cells, it also interacts with the enzyme components of iota toxin and CDT, suggesting a common principle for this toxin family. | Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins.
Ernst K, Langer S, Kaiser E, Osseforth C, Michaelis J, Popoff MR, Schwan C, Aktories K, Kahlert V, Malesevic M, Schiene-Fischer C, Barth H. | 05/16/2015 |
| The Photorhabdus toxins TccC3 and TccC5 interacted with Hsp90, FKBP51, Cyp40 and CypA, suggesting a role of these host cell factors in translocation and/or refolding of the ADP-ribosyltransferases. | The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases.
Lang AE, Ernst K, Lee H, Papatheodorou P, Schwan C, Barth H, Aktories K. | 11/8/2014 |
| this is the first report establishing an important role for Cyp40 in lymphoma. | The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein.
Pearson JD, Mohammed Z, Bacani JT, Lai R, Ingham RJ., Free PMC Article | 12/22/2012 |
| Data show that disruption of FKBP51 and Cyp40 in AI C4-2 cells caused only a small reduction in proliferation. | FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A.
Periyasamy S, Hinds T Jr, Shemshedini L, Shou W, Sanchez ER., Free PMC Article | 05/3/2010 |
| Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect | Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect.
Eliseev RA, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter TE., Free PMC Article | 01/21/2010 |
| CyP40 is found in the cell nucleus after 3-methylchloranthrene treatment and appears to promote the dioxin response element binding form of the AhR/Arnt heterodimer. | Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling.
Luu TC, Bhattacharya P, Chan WK., Free PMC Article | 01/21/2010 |
| CypD-mediated mitochondrial permeability transition pore is directly linked to the cellular and synaptic perturbations observed in the pathogenesis of Alzheimer's disease. | Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD., Free PMC Article | 01/21/2010 |
| CyP40 chaperone function then, is localized within the linker that forms a binding cleft with potential to accommodate non-native substrates | The chaperone function of cyclophilin 40 maps to a cleft between the prolyl isomerase and tetratricopeptide repeat domains.
Mok D, Allan RK, Carrello A, Wangoo K, Walkinshaw MD, Ratajczak T. | 01/21/2010 |
| cyclophilin D suppresses apoptotic cell death via a mitochondrial hexokinase II-dependent mechanism in cancer cells | Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.
Machida K, Ohta Y, Osada H. | 01/21/2010 |