| Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism. | Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism.
Men M, Wang X, Wu J, Zeng W, Jiang F, Zheng R, Li JD. | 09/11/2021 |
| Elevation of circ-PITX1 upregulates interleukin 17 receptor D expression via sponging miR-518a-5p and facilitates cell progression in glioma. | Elevation of circ-PITX1 upregulates interleukin 17 receptor D expression via sponging miR-518a-5p and facilitates cell progression in glioma.
Zhan L, Mu Z, Yang M, Zhang T, Li H, Qian L. | 09/5/2020 |
| This study provides new insights into structure-function relation of Sef protein and the molecular mechanism by which Sef serves to limit classical NF-kappaB transcriptional activity. | The tumor suppressor Sef is a scaffold for the classical NF-κB/RELA:P50 signaling module.
Korsensky L, Haif S, Heller R, Rabinovitz S, Haddad-Halloun J, Dahan N, Ron D. | 08/12/2020 |
| IL-17RD is a functional receptor for IL-17A in vitro and in vivo and mediates the proinflammatory gene expression downstream of IL-17A.. | Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation.
Su Y, Huang J, Zhao X, Lu H, Wang W, Yang XO, Shi Y, Wang X, Lai Y, Dong C. | 05/16/2020 |
| MAPK signaling dependency in epithelial lung cancer cells is due to the scaffold protein interleukin-17 receptor D (IL17RD), which is directly repressed by ZEB1. | ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism.
Peng DH, Kundu ST, Fradette JJ, Diao L, Tong P, Byers LA, Wang J, Canales JR, Villalobos PA, Mino B, Yang Y, Minelli R, Peoples MD, Bristow CA, Heffernan TP, Carugo A, Wistuba II, Gibbons DL., Free PMC Article | 02/22/2020 |
| miR-193a-3p is downregulated in ulcerative colitis neoplasia, and its loss promotes carcinogenesis through upregulation of IL17RD. These findings provide novel insight into inflammation-driven colorectal cancer and could suggest new therapeutic targets in this high-risk population | miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD.
Pekow J, Meckel K, Dougherty U, Huang Y, Chen X, Almoghrabi A, Mustafi R, Ayaloglu-Butun F, Deng Z, Haider HI, Hart J, Rubin DT, Kwon JH, Bissonnette M., Free PMC Article | 06/23/2018 |
| Low SEF expression is associated with Epithelial-Mesenchymal Transition in Breast Cancer and thus Metastasis in breast Cancer. | Sef Regulates Epithelial-Mesenchymal Transition in Breast Cancer Cells.
He Q, Gong Y, Gower L, Yang X, Friesel RE., Free PMC Article | 08/19/2017 |
| Taken together, these data suggest evidence that loss of hSef may be a critical event facilitating tumor dissemination of prostate cancer through alteration of EMT. | Loss of hSef promotes metastasis through upregulation of EMT in prostate cancer.
Hori S, Wadhwa K, Pisupati V, Zecchini V, Ramos-Montoya A, Warren AY, Neal DE, Gnanapragasam VJ., Free PMC Article | 05/6/2017 |
| IL17RD negatively regulates Toll-like receptor (TLR)-induced responses. | Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.
Mellett M, Atzei P, Bergin R, Horgan A, Floss T, Wurst W, Callanan JJ, Moynagh PN. | 03/26/2016 |
| Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms. | Expression and regulation of the tumor suppressor, SEF, during folliculogenesis in humans and mice.
Lutwak E, Price CA, Abramovich SS, Rabinovitz S, Granot I, Dekel N, Ron D. | 06/20/2015 |
| Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis. | Loss of expressions of Dusp6, Sprouty4, and Sef, negative regulators of FGF2/ERK1/2 signaling, in the endometrium of women with adenomyosis.
Guo Q, Zhang H, Zhao X, Fu Y, Zhang J, Li M. | 04/18/2015 |
| These results reveal Sef-S actives Lys63-linked TAK1 polyubiquitination on lysine 209, induces TAK1-mediated JNK and p38 activation and also results apoptosis in 293T cells. | Activation of TAK1 by Sef-S induces apoptosis in 293T cells.
Sun X, Wang Y, Yang S, Ren F, Xia Y, Chang Z. | 03/8/2014 |
| FGF17 and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism. | Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N., Free PMC Article | 07/6/2013 |
| Downregulation of SEF mRNA is associated with prostate cancer. | Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer.
Kachroo N, Valencia T, Warren AY, Gnanapragasam VJ., Free PMC Article | 04/27/2013 |
| Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia. | Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.
Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN. | 02/2/2013 |
| This study establishes Sef as a feedback antagonist of proinflammatory cytokines and highlights its potential to regulate the crosstalk between proinflammatory cytokine receptors and receptor tyrosine kinases. | Sef is an inhibitor of proinflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB.
Fuchs Y, Brunwasser M, Haif S, Haddad J, Shneyer B, Goldshmidt-Tran O, Korsensky L, Abed M, Zisman-Rozen S, Koren L, Carmi Y, Apte R, Yang RB, Orian A, Bejar J, Ron D. | 01/12/2013 |
| The expression of hSef is decreased in epithelial ovarian carcinoma tissue, but the expression of FGF-2 is increased. | [Expression of hSef and FGF-2 in epithelial ovarian tumor].
Feng QL, Shi HR, Qiao LJ, Zhao J. | 12/8/2012 |
| Findings indicate that Ras-induced nuclear accumulation of activated MEK1/2 was reliant on downregulation of the spatial regulator Sef. | Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S. | 03/31/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. | 12/5/2010 |
| IL 17RD protein is a part of the Interleukin-17 receptor signaling complex, therefore providing novel evidence for Interleukin-17 signaling through a heteromeric and/or homomeric receptor complex. | IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling.
Rong Z, Wang A, Li Z, Ren Y, Cheng L, Li Y, Wang Y, Ren F, Zhang X, Hu J, Chang Z., Free PMC Article | 01/21/2010 |
| Sef plays a positive role in the EGF/EGFR-mediated MAPK signaling pathway. | hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation.
Ren Y, Cheng L, Rong Z, Li Z, Li Y, Zhang X, Xiong S, Hu J, Fu XY, Chang Z., Free PMC Article | 01/21/2010 |
| Inhibitory effect of hSef on cell proliferation combined with consistent downregulation in human carcinoma indicates a tumor suppressor-like role for Sef. | Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas.
Zisman-Rozen S, Fink D, Ben-Izhak O, Fuchs Y, Brodski A, Kraus MH, Bejar J, Ron D. | 01/21/2010 |
| Sef inhibited FGF induced, but not RasG12V mediated, signal transduction. We propose that Sef interacted with Ras in the inhibition of Ras/MAPK signaling pathway. | hSef co-localizes and interacts with Ras in the inhibition of Ras/MAPK signaling pathway.
Ren Y, Cheng L, Rong Z, Li Z, Li Y, Li H, Wang Z, Chang Z. | 01/21/2010 |
| HSef acts as a spatial regulator for ERK signaling by targeting ERK to the cytoplasm. | Sef is a spatial regulator for Ras/MAP kinase signaling.
Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E. | 01/21/2010 |
| human SEF is likely to play critical roles in endothelial or epithelial functions such as proliferation, migration, and angiogenesis | A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling.
Yang RB, Ng CK, Wasserman SM, Kömüves LG, Gerritsen ME, Topper JN. | 01/21/2010 |