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    FEV FEV transcription factor, ETS family member [ Homo sapiens (human) ]

    Gene ID: 54738, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Tumor Suppressor Role and Clinical Significance of the FEV Gene in Prostate Cancer.

    Tumor Suppressor Role and Clinical Significance of the FEV Gene in Prostate Cancer.
    Liang YX, Liang YK, Zou ZH, Zhuo YJ, Ye JH, Zhu XJ, Cai ZD, Lin ZY, Mo RJ, Wu SL, Zhang YQ, Zhong WD., Free PMC Article

    05/28/2022
    Ewing sarcoma with FEV gene rearrangements is a rare subset with predilection for extraskeletal locations and aggressive behavior.

    Ewing sarcoma with FEV gene rearrangements is a rare subset with predilection for extraskeletal locations and aggressive behavior.
    Tsuda Y, Dickson BC, Swanson D, Sung YS, Zhang L, Meyers P, Healey JH, Antonescu CR., Free PMC Article

    10/31/2020
    This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents.

    Association of genetic variations in the serotonin and dopamine systems with aggressive behavior in the Chinese adolescent population: Single- and multiple-risk genetic variants.
    Chang H, Yan Q, Tang L, Huang J, Ma Y, Ye X, Wu C, Wu L, Yu Y.

    04/14/2018
    identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin

    Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin.
    Liu TH, Tang YJ, Huang Y, Wang L, Guo XL, Mi JQ, Liu LG, Zhu H, Zhang Y, Chen L, Liu X, Zhang LH, Ye QJ, Li BS, Tang JY, Ford A, Enver T, Liu F, Chen GQ, Hong DL.

    09/16/2017
    Genetic variation in FEV1 was associated with serum 25-Hydroxyvitamin D status.

    Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study.
    Hansen JG, Gao W, Dupuis J, O'Connor GT, Tang W, Kowgier M, Sood A, Gharib SA, Palmer LJ, Fornage M, Heckbert SR, Psaty BM, Booth SL, SUNLIGHT Consortium, Cassano PA., Free PMC Article

    04/2/2016
    novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation

    Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.
    Wellman CL, Camp M, Jones VM, MacPherson KP, Ihne J, Fitzgerald P, Maroun M, Drabant E, Bogdan R, Hariri AR, Holmes A., Free PMC Article

    02/1/2014
    Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development.

    Fev regulates hematopoietic stem cell development via ERK signaling.
    Wang L, Liu T, Xu L, Gao Y, Wei Y, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong D, Liu F.

    09/28/2013
    our data argue against an exclusive role of FEV in the adult human brain serotonergic system and genetic analyses did not suggest that FEV variation adds to the genetic liability towards affective disorders

    The expression of the transcription factor FEV in adult human brain and its association with affective disorders.
    Kriegebaum CB, Gutknecht L, Bartke L, Reif A, Buttenschon HN, Mors O, Lesch KP, Schmitt AG.

    10/30/2010
    FEV identifies serotonin-producing cells in normal and neoplastic small intestine.

    The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
    Wang YC, Zuraek MB, Kosaka Y, Ota Y, German MS, Deneris ES, Bergsland EK, Donner DB, Warren RS, Nakakura EK.

    06/28/2010
    Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population.

    Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population.
    Broadbelt KG, Barger MA, Paterson DS, Holm IA, Haas EA, Krous HF, Kinney HC, Markianos K, Beggs AH, Broadbelt KG, Barger MA, Paterson DS, Holm IA, Haas EA, Krous HF, Kinney HC, Markianos K, Beggs AH., Free PMC Articles: PMC2802663, PMC2802663

    03/29/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (4) articles

    The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
    Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF.

    Association study of 182 candidate genes in anorexia nervosa.
    Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB.

    Genetical genomic determinants of alcohol consumption in rats and humans.
    Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism.

    Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population.
    Broadbelt KG, Barger MA, Paterson DS, Holm IA, Haas EA, Krous HF, Kinney HC, Markianos K, Beggs AH, Broadbelt KG, Barger MA, Paterson DS, Holm IA, Haas EA, Krous HF, Kinney HC, Markianos K, Beggs AH.

    09/16/2009
    Variation in FEV gene observed exclusively in a subset of African American sudden infant death syndrome cases may help explain the observed abnormalities of this system in some SIDS cases and the ethnic disparity.

    Sudden infant death syndrome: rare mutation in the serotonin system FEV gene.
    Rand CM, Berry-Kravis EM, Zhou L, Fan W, Weese-Mayer DE.

    01/21/2010
    We showed that fev is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-HT transporter (sert) and tryptophan hydroxylase (tph), two markers of the 5-HT neurotransmitter system.

    The Ets transcription factor Fev is specifically expressed in the human central serotonergic neurons.
    Maurer P, Rorive S, de Kerchove d'Exaerde A, Schiffmann SN, Salmon I, de Launoit Y.

    01/21/2010
    Analysis of transgene expression in Pet-1 null mice indicates that Pet-1 is required to maintain the activity of the Pet-1 enhancer region in a subset of serotonin (5-HT) neurons.

    A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development.
    Scott MM, Krueger KC, Deneris ES., Free PMC Article

    01/21/2010
    FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain.

    FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain.
    Maurer P, T'Sas F, Coutte L, Callens N, Brenner C, Van Lint C, de Launoit Y, Baert JL.

    01/21/2010
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