| MPP8 Promotes Proliferation and Restrains Apoptosis in Osteosarcoma by Regulating p38alphaMAPK Pathway. | MPP8 Promotes Proliferation and Restrains Apoptosis in Osteosarcoma by Regulating p38αMAPK Pathway.
Li T, Li N, Wang L, Li J, Zhang X., Free PMC Article | 11/27/2021 |
| M-phase phosphoprotein 8 promotes gastric cancer growth and metastasis via p53/Bcl-2 and EMT-related signaling pathways. | M-phase phosphoprotein 8 promotes gastric cancer growth and metastasis via p53/Bcl-2 and EMT-related signaling pathways.
Wang Y, Xiao H, Wang C, Wu H, He H, Yao C, Cui J, Li W. | 06/19/2021 |
| The study demonstrated that MPP8 was associated with non-small cell lung cancer cell proliferation through regulation of HOXA5. | Knockdown of MPP8 suppresses cell proliferation via regulation of HOXA5 in non-small cell lung cancer cells.
Gao XY, Qiao YL, Zhang Y, Wang J, Shen X, Xu CW. | 08/11/2018 |
| The haploid screen identified HUSH, an epigenetic heterochromatin repressor complex composed of three subunits, TASOR, MPP8 and Periphilin. (Review) | Position-effect variegation revisited: HUSHing up heterochromatin in human cells.
Timms RT, Tchasovnikarova IA, Lehner PJ. | 01/14/2017 |
| findings demonstrate MPP8 and SIRT1 reciprocally regulate each other's function at multiple molecular layers through physical interaction; disruption of MPP8-SIRT1 interaction de-represses E cadherin expression and reduces cell motility and invasiveness suggesting this interplay plays critical role in MPP8- and SIRT1-mediated epithelial-mesenchymal transition | MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition.
Sun L, Kokura K, Izumi V, Koomen JM, Seto E, Chen J, Fang J., Free PMC Article | 03/12/2016 |
| this study identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphilin; this complex is absent from Drosophila but is conserved from fish to humans. | GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ., Free PMC Article | 07/25/2015 |
| Knockdown analysis of MPP8 in HeLa cells resulted in derepression of a set of genes that are normally expressed in spermatogonia, spermatids and mature sperm, thereby indicating a role for this molecule in silencing testis-related genes in somatic cells. | Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.
Murata K, Sato S, Haruta M, Goshima T, Chiba Y, Takahashi S, Sharif J, Koseki H, Nakanishi M, Shimada M. | 05/16/2015 |
| interaction of HN with MPP8 may play a role in oncogenesis because MPP8 increases tumor cell motility and invasion | Humanin binds MPP8: mapping interaction sites of the peptide and protein.
Maximov VV, Martynenko AV, Arman IP, Tarantul VZ. | 11/2/2013 |
| these results indicate that the chromatin association of MPP8 is regulated by Cdk-dependent phosphorylation. | Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation.
Nishigaki M, Kawada Y, Misaki T, Murata K, Goshima T, Hirokawa T, Yamada C, Shimada M, Nakanishi M. | 09/28/2013 |
| These findings reveal the molecular mechanism of selective binding of human MPP8 chromodomain to methylated histone H3K9. | Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.
Li J, Li Z, Ruan J, Xu C, Tong Y, Pan PW, Tempel W, Crombet L, Min J, Zang J., Free PMC Article | 02/18/2012 |
| We determined the crystal structure of MPP8 chromodomain in complex with H3K9me3 peptide. MPP8 interacts with at least six histone H3 residues from glutamine 5 to serine 10. | Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding.
Chang Y, Horton JR, Bedford MT, Zhang X, Cheng X., Free PMC Article | 07/16/2011 |
| MPP8 mediates E-cadherin gene silencing and promotes breast tumour cell motility and invasion. | Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion.
Kokura K, Sun L, Bedford MT, Fang J., Free PMC Article | 12/11/2010 |