| A common Alu insertion in the 3'UTR of TMEM106B is associated with risk of dementia. | A common Alu insertion in the 3'UTR of TMEM106B is associated with risk of dementia.
Rodney A, Karanjeet K, Benzow K, Koob MD., Free PMC Article | 07/22/2024 |
| Physiological and pathological functions of TMEM106B in neurodegenerative diseases. | Physiological and pathological functions of TMEM106B in neurodegenerative diseases.
Zhu M, Zhang G, Meng L, Xiao T, Fang X, Zhang Z., Free PMC Article | 07/12/2024 |
| Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions. | Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions.
Picard C, Miron J, Poirier J., Free PMC Article | 05/20/2024 |
| TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. | TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.
Marks JD, Ayuso VE, Carlomagno Y, Yue M, Todd TW, Hao Y, Li Z, McEachin ZT, Shantaraman A, Duong DM, Daughrity LM, Jansen-West K, Shao W, Calliari A, Bejarano JG, DeTure M, Rawlinson B, Casey MC, Lilley MT, Donahue MH, Jawahar VM, Boeve BF, Petersen RC, Knopman DS, Oskarsson B, Graff-Radford NR, Wszolek ZK, Dickson DW, Josephs KA, Qi YA, Seyfried NT, Ward ME, Zhang YJ, Prudencio M, Petrucelli L, Cook CN., Free PMC Article | 01/30/2024 |
| C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes. | C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes.
T Vicente C, Perneel J, Wynants S, Heeman B, Van den Broeck M, Baker M, Cheung S, Faura J, Mackenzie IRA, Rademakers R., Free PMC Article | 10/10/2023 |
| The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus. | The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus.
Lee JY, Harney DJ, Teo JD, Kwok JB, Sutherland GT, Larance M, Don AS., Free PMC Article | 09/22/2023 |
| Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation. | Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation.
Xing S, Zheng X, Yan H, Mo Y, Duan R, Chen Z, Wang K, Gao K, Chen T, Zhao S, Wang J, Chen L. | 08/22/2023 |
| TMEM106B Fibrils from FTLD Patients and Healthy Controls. | TMEM106B Fibrils from FTLD Patients and Healthy Controls.
Greenwood JD, Powell WC, Walczak MA., Free PMC Article | 08/17/2023 |
| TMEM106B aggregation in neurodegenerative diseases: linking genetics to function. | TMEM106B aggregation in neurodegenerative diseases: linking genetics to function.
Jiao HS, Yuan P, Yu JT., Free PMC Article | 08/16/2023 |
| TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry. | TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.
Baggen J, Jacquemyn M, Persoons L, Vanstreels E, Pye VE, Wrobel AG, Calvaresi V, Martin SR, Roustan C, Cronin NB, Reading E, Thibaut HJ, Vercruysse T, Maes P, De Smet F, Yee A, Nivitchanyong T, Roell M, Franco-Hernandez N, Rhinn H, Mamchak AA, Ah Young-Chapon M, Brown E, Cherepanov P, Daelemans D., Free PMC Article | 08/7/2023 |
| Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging. | Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging.
Perneel J, Neumann M, Heeman B, Cheung S, Van den Broeck M, Wynants S, Baker M, Vicente CT, Faura J, Rademakers R, Mackenzie IRA. | 02/27/2023 |
| Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease. | Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease.
Perneel J, Rademakers R., Free PMC Article | 10/15/2022 |
| TMEM106B Acts as a Modifier of Cognitive and Motor Functions in Amyotrophic Lateral Sclerosis. | TMEM106B Acts as a Modifier of Cognitive and Motor Functions in Amyotrophic Lateral Sclerosis.
Manini A, Ratti A, Brusati A, Maranzano A, Fogh I, Peverelli S, Messina S, Gentilini D, Verde F, Poletti B, Morelli C, Silani V, Ticozzi N., Free PMC Article | 09/3/2022 |
| TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins. | TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
Levine TP. | 07/16/2022 |
| Age-dependent formation of TMEM106B amyloid filaments in human brains. | Age-dependent formation of TMEM106B amyloid filaments in human brains.
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lövestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW., Free PMC Article | 06/11/2022 |
| Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Ogorzalek Loo RR, Loo JA, Eisenberg DS., Free PMC Article | 06/11/2022 |
| Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. | Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson DW, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP., Free PMC Article | 05/7/2022 |
| TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels. | TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels.
Hong S, Dobricic V, Ohlei O, Bos I, Vos SJB, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Gabel S, Scheltens P, Teunissen CE, Engelborghs S, Frisoni G, Blin O, Richardson JC, Bordet R, Alzheimer's Disease Neuroimaging Initiative (ADNI), Lleó A, Alcolea D, Popp J, Clark C, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Tanzi RE, Ten Kate M, Wittig M, Franke A, Lill CM, Barkhof F, Lovestone S, Streffer J, Zetterberg H, Visser PJ, Bertram L. | 01/1/2022 |
| A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP. | A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP.
Llibre-Guerra JJ, Lee SE, Suemoto CK, Ehrenberg AJ, Kovacs GG, Karydas A, Staffaroni A, Franca Resende EP, Kim EJ, Hwang JH, Ramos EM, Wojta KJ, Pasquini L, Pang SY, Spina S, Allen IE, Kramer J, Miller BL, Seeley WW, Grinberg LT., Free PMC Article | 12/25/2021 |
| rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues. | rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues.
Hu Y, Sun JY, Zhang Y, Zhang H, Gao S, Wang T, Han Z, Wang L, Sun BL, Liu G., Free PMC Article | 06/26/2021 |
| Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2. | Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2.
Baggen J, Persoons L, Vanstreels E, Jansen S, Van Looveren D, Boeckx B, Geudens V, De Man J, Jochmans D, Wauters J, Wauters E, Vanaudenaerde BM, Lambrechts D, Neyts J, Dallmeier K, Thibaut HJ, Jacquemyn M, Maes P, Daelemans D. | 05/8/2021 |
| Progranulin and TMEM106B: when two become wan. | Progranulin and TMEM106B: when two become wan.
Clayton EL, Isaacs AM., Free PMC Article | 05/1/2021 |
| Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies. | Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.
Zhou X, Nicholson AM, Ren Y, Brooks M, Jiang P, Zuberi A, Phuoc HN, Perkerson RB, Matchett B, Parsons TM, Finch NA, Lin W, Qiao W, Castanedes-Casey M, Phillips V, Librero AL, Asmann Y, Bu G, Murray ME, Lutz C, Dickson DW, Rademakers R., Free PMC Article | 01/23/2021 |
| The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion. | The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.
Li Z, Farias FHG, Dube U, Del-Aguila JL, Mihindukulasuriya KA, Fernandez MV, Ibanez L, Budde JP, Wang F, Lake AM, Deming Y, Perez J, Yang C, Bahena JA, Qin W, Bradley JL, Davenport R, Bergmann K, Morris JC, Perrin RJ, Benitez BA, Dougherty JD, Harari O, Cruchaga C., Free PMC Article | 01/23/2021 |
| Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts. | Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts.
Hokkanen SRK, Kero M, Kaivola K, Hunter S, Keage HAD, Kiviharju A, Raunio A, Tienari PJ, Paetau A, Matthews FE, Fleming J, Graff C, Polvikoski TM, Myllykangas L, Brayne C, EClipSE Collaboration., Free PMC Article | 01/16/2021 |