| PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype. | PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype.
Sturniolo I, Váróczy C, Regdon Z, Mázló A, Muzsai S, Bácsi A, Intili G, Hegedűs C, Boothby MR, Holechek J, Ferraris D, Schüler H, Virág L., Free PMC Article | 04/17/2024 |
| Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma. | Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Zhang H, Wang H, Hu Y, Gao Y, Chen J, Meng Y, Qiu Y, Hu R, Liao P, Li M, He Y, Liang Z, Xie X, Li Y. | 04/12/2024 |
| PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L. | PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L.
Zhang L, Chen W, Shi Z, Shang Z. | 03/26/2024 |
| Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker. | Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker.
Wang H, Luo S, Wu X, Ruan Y, Qiu L, Feng H, Zhu S, You Y, Li M, Yang W, Zhao Y, Tao X, Jiang H., Free PMC Article | 11/16/2023 |
| NMR study of human macroPARPs domains: (1)H, (15)N and (13)C resonance assignment of hPARP14 macro domain 2 in the free and the ADPr bound state. | NMR study of human macroPARPs domains: (1)H, (15)N and (13)C resonance assignment of hPARP14 macro domain 2 in the free and the ADPr bound state.
Fourkiotis NK, Charalampous P, Tsika AC, Kravvariti KP, Sideras-Bisdekis C, Gallo A, Spyroulias GA., Free PMC Article | 10/8/2022 |
| PARP14 promotes the growth and glycolysis of acute myeloid leukemia cells by regulating HIF-1alpha expression. | PARP14 promotes the growth and glycolysis of acute myeloid leukemia cells by regulating HIF-1α expression.
Zhu Y, Liu Z, Wan Y, Zou L, Liu L, Ding S, Lu C, Qiu F. | 09/24/2022 |
| PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells. | PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells.
Mashimo M, Shimizu A, Mori A, Hamaguchi A, Fukushima K, Seira N, Fujii T, Fujino H. | 09/3/2022 |
| PARP14 regulates cyclin D1 expression to promote cell-cycle progression. | PARP14 regulates cyclin D1 expression to promote cell-cycle progression.
O'Connor MJ, Thakar T, Nicolae CM, Moldovan GL., Free PMC Article | 01/8/2022 |
| The potential association between PARP14 and SARS-CoV-2 infection (COVID-19). | The potential association between PARP14 and SARS-CoV-2 infection (COVID-19).
Tauber AL, Schweiker SS, Levonis SM., Free PMC Article | 03/28/2021 |
| Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR. | Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR.
Dhoonmoon A, Schleicher EM, Clements KE, Nicolae CM, Moldovan GL., Free PMC Article | 09/19/2020 |
| This study summarizes specific molecular pathways, including those involving poly(ADP-ribose) polymerase family member 14 (PARP14) and poly(ADP-ribose) polymerase family member 9 (PARP9) at the intersection of interferon gamma (IFN-gamma) and ADP-ribosylation signaling pathways. | A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation.
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M., Free PMC Article | 06/6/2020 |
| PARP14 could promote Pancreatic cancer cell proliferation, antiapoptosis, and gemcitabine resistance via NF-kappaB signaling pathway, highlighting its potential role as a therapeutic target for Pancreatic cancer. | PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-κB pathway.
Yao N, Chen Q, Shi W, Tang L, Fu Y. | 11/9/2019 |
| murine Artd8 macrodomain constructs can serve as a tool to evaluate intracellular ARTD10 auto-modification levels using the described methods, while the human ARTD8 macrodomains are less suited because of ADPr-independent binding to ARTD10. Protocols for co-immunoprecipitation and co-localization experiments are described in detail. | Assessment of Intracellular Auto-Modification Levels of ARTD10 Using Mono-ADP-Ribose-Specific Macrodomains 2 and 3 of Murine Artd8.
Bütepage M, Krieg S, Eckei L, Li J, Rossetti G, Verheugd P, Lüscher B. | 03/16/2019 |
| PARP9 and PARP14 regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4; PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells | PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M., Free PMC Article | 09/22/2018 |
| The PARP14-JNK1-PKM2 regulatory axis is an important determinant for the Warburg effect in tumour cells and provides a mechanistic link between apoptosis and metabolism. | PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation.
Iansante V, Choy PM, Fung SW, Liu Y, Chai JG, Dyson J, Del Rio A, D'Santos C, Williams R, Chokshi S, Anders RA, Bubici C, Papa S., Free PMC Article | 05/14/2016 |
| PARP14 interacts with the DNA replication machinery component PCNA and promotes replication of DNA lesions and common fragile sites. | A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress.
Nicolae CM, Aho ER, Choe KN, Constantin D, Hu HJ, Lee D, Myung K, Moldovan GL., Free PMC Article | 06/27/2015 |
| The present study further suggests that the combined targeted inhibition of STAT1, ARTD8, ARTD9 and/or DTX3L could increase the efficacy of chemotherapy or radiation treatment in prostate and other high-risk tumor types with an increased STAT1 signaling. | DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells.
Bachmann SB, Frommel SC, Camicia R, Winkler HC, Santoro R, Hassa PO., Free PMC Article | 12/20/2014 |
| PARP14 has a significant role in the development of allergic inflammation, and targeting PARP14, or even PARP activity in general, might be an effective therapy for allergic diseases including eosinophilic esophagitis. | Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis.
Krishnamurthy P, Sherrill JD, Parashette K, Goenka S, Rothenberg ME, Gupta S, Kaplan MH., Free PMC Article | 05/17/2014 |
| Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma. | Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma.
Barbarulo A, Iansante V, Chaidos A, Naresh K, Rahemtulla A, Franzoso G, Karadimitris A, Haskard DO, Papa S, Bubici C. | 11/2/2013 |
| loss of PARP14 protein is a feature of gastric and colorectal cancers with high microsatellite instability and these alterations might contribute to development of cancers with high microsatellite instability by deregulating PARP-mediated signaling | Frameshift mutations of poly(adenosine diphosphate-ribose) polymerase genes in gastric and colorectal cancers with microsatellite instability.
Kim MS, An CH, Kim SS, Yoo NJ, Lee SH. | 10/15/2011 |
| PARP enzymatic activity is associated with CoaSt6, and this function of CoaSt6 can append ADP-ribose to itself and p100 | Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription.
Goenka S, Cho SH, Boothby M. | 01/21/2010 |
| BAL macro domains repress transcription when tethered to a promoter; BAL2 and BAL3, but not BAL1, exhibit PARP activity | B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity.
Aguiar RC, Takeyama K, He C, Kreinbrink K, Shipp MA. | 01/21/2010 |