| NELF and PAF1C complexes are core transcriptional machineries controlling colon cancer stemness. | NELF and PAF1C complexes are core transcriptional machineries controlling colon cancer stemness.
Aoki K, Nitta A, Igarashi A., Free PMC Article | 02/22/2024 |
| RFX2 promotes tumor cell stemness through epigenetic regulation of PAF1 in spinal ependymoma. | RFX2 promotes tumor cell stemness through epigenetic regulation of PAF1 in spinal ependymoma.
Zhang Z, Chen Y, Guo Y, Shen H, Wang J, Chen H. | 01/5/2024 |
| Elevated PAF1-RAD52 axis confers chemoresistance to human cancers. | Elevated PAF1-RAD52 axis confers chemoresistance to human cancers.
Rauth S, Ganguly K, Atri P, Parte S, Nimmakayala RK, Varadharaj V, Nallasamy P, Vengoji R, Ogunleye AO, Lakshmanan I, Chirravuri R, Bessho M, Cox JL, Foster JM, Talmon GA, Bessho T, Ganti AK, Batra SK, Ponnusamy MP., Free PMC Article | 10/5/2023 |
| Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression. | Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression.
Liu X, Liu X, Du Y, Zou D, Tian C, Li Y, Lan X, David CJ, Sun Q, Chen M. | 09/26/2023 |
| CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1. | CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1.
Zhang B, Zhao B, Han S, Chen S. | 09/23/2023 |
| Role of the Paf1 complex in the maintenance of stem cell pluripotency and development. | Role of the Paf1 complex in the maintenance of stem cell pluripotency and development.
Park J, Park S, Lee JS. | 02/24/2023 |
| PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer. | PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer.
Nimmakayala RK, Ogunleye AO, Parte S, Krishna Kumar N, Raut P, Varadharaj V, Perumal NK, Nallasamy P, Rauth S, Cox JL, Lele SM, Batra SK, Ponnusamy MP., Free PMC Article | 10/8/2022 |
| Crystal Structure of the Core Module of the Yeast Paf1 Complex. | Crystal Structure of the Core Module of the Yeast Paf1 Complex.
Chen F, Liu B, Zeng J, Guo L, Ge X, Feng W, Li DF, Zhou H, Long J. | 02/5/2022 |
| SUMO Modification of PAF1/PD2 Enables PML Interaction and Promotes Radiation Resistance in Pancreatic Ductal Adenocarcinoma. | SUMO Modification of PAF1/PD2 Enables PML Interaction and Promotes Radiation Resistance in Pancreatic Ductal Adenocarcinoma.
Rauth S, Karmakar S, Shah A, Seshacharyulu P, Nimmakayala RK, Ganguly K, Bhatia R, Muniyan S, Kumar S, Dutta S, Lin C, Datta K, Batra SK, Ponnusamy MP., Free PMC Article | 12/25/2021 |
| Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling. | Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling.
Chen Z, Hankey W, Zhao Y, Groth J, Huang F, Wang H, Campos AR, Huang J, Roeder RG, Wang Q., Free PMC Article | 12/11/2021 |
| RNA Polymerase II-Associated Factor 1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions With PHF5A and DDX3. | RNA Polymerase II-Associated Factor 1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions With PHF5A and DDX3.
Karmakar S, Rauth S, Nallasamy P, Perumal N, Nimmakayala RK, Leon F, Gupta R, Barkeer S, Venkata RC, Raman V, Rachagani S, Ponnusamy MP, Batra SK., Free PMC Article | 04/17/2021 |
| Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription. | Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription.
Zheng JJ, He Y, Liu Y, Li FS, Cui Z, Du XM, Wang CP, Wu YM., Free PMC Article | 04/3/2021 |
| A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair. | A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair.
van den Heuvel D, Spruijt CG, González-Prieto R, Kragten A, Paulsen MT, Zhou D, Wu H, Apelt K, van der Weegen Y, Yang K, Dijk M, Daxinger L, Marteijn JA, Vertegaal ACO, Ljungman M, Vermeulen M, Luijsterburg MS., Free PMC Article | 03/20/2021 |
| These data highlight that human PAF1C is an important transcriptional regulator of expanded G4C2 within C9orf72 | Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.
Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM., Free PMC Article | 07/6/2019 |
| Study reports 2.53 A atomic structures of both the human PAF1/CTR9 and yeast Paf1/Ctr9 heterodimers. Results clearly reveal that the heterodimer of PAF1/CTR9 or Paf1/Ctr9 is the core component of evolutionarily conserved multifunctional polymerase-associated factor 1 complex (Paf1C) and is important for human PAF1C or yeast Paf1C assembly, yeast viability, and Paf1C-mediated histone modifications. | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation.
Xie Y, Zheng M, Chu X, Chen Y, Xu H, Wang J, Zhou H, Long J., Free PMC Article | 01/19/2019 |
| a subset of enhancers can primarily modulate gene expression by controlling the release of paused Pol II in a PAF1-dependent manner. | PAF1 regulation of promoter-proximal pause release via enhancer activation.
Chen FX, Xie P, Collings CK, Cao K, Aoi Y, Marshall SA, Rendleman EJ, Ugarenko M, Ozark PA, Zhang A, Shiekhattar R, Smith ER, Zhang MQ, Shilatifard A., Free PMC Article | 03/10/2018 |
| These results reveal ubiquitin-proteasome system regulation of Paf1 and suggest downregulation of ubiquitin-proteasome system in elevating Paf1's abundance in poorly differentiated cancers. | Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis.
Ferdoush J, Karmakar S, Barman P, Kaja A, Uprety B, Batra SK, Bhaumik SR. | 12/23/2017 |
| The various functions of Paf1C, such as the regulation of promoter-proximal pausing and development in higher eukaryotes, are complex and context dependent. | Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation.
Van Oss SB, Cucinotta CE, Arndt KM., Free PMC Article | 10/14/2017 |
| High PAF1 expression is associated with ovarian cancer. | hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells.
Karmakar S, Seshacharyulu P, Lakshmanan I, Vaz AP, Chugh S, Sheinin YM, Mahapatra S, Batra SK, Ponnusamy MP., Free PMC Article | 10/7/2017 |
| Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma. | Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma.
Vaz AP, Deb S, Rachagani S, Dey P, Muniyan S, Lakshmanan I, Karmakar S, Smith L, Johansson S, Lele S, Ouellette M, Ponnusamy MP, Batra SK., Free PMC Article | 12/17/2016 |
| Propose that degradation of MYC limits the accumulation of MYC/PAF1C complexes during transcriptional activation. | Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.
Jaenicke LA, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg AK, Geyer M, Eilers M, Popov N. | 05/28/2016 |
| Mechanistic studies indicated that PAF1C could promote lung cancer cell proliferation through regulating c-MYC transcription. | Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.
Zhi X, Giroux-Leprieur E, Wislez M, Hu M, Zhang Y, Shi H, Du K, Wang L. | 04/16/2016 |
| CNOT4 controls the degradation of chromatin-unbound PAF1 via the 26S proteasome. | Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome.
Sun HY, Kim N, Hwang CS, Yoo JY., Free PMC Article | 02/6/2016 |
| this study found that Pol II-associated factor 1 (PAF1) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regulates the initial recruitment of PAF1 complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 is dependent on PAF1C. | RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
Yu M, Yang W, Ni T, Tang Z, Nakadai T, Zhu J, Roeder RG., Free PMC Article | 01/16/2016 |
| This study reveals an evolutionarily conserved role for PAF1 as a regulator of promoter-proximal pausing by RNA Pol II in all metazoans, including human. | PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.
Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A., Free PMC Article | 11/28/2015 |