| Dissolution of ribonucleoprotein condensates by the embryonic stem cell protein L1TD1. | Dissolution of ribonucleoprotein condensates by the embryonic stem cell protein L1TD1.
Jin SW, Seong Y, Yoon D, Kwon YS, Song H., Free PMC Article | 05/9/2024 |
| Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians. | Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians.
Bandesh K, Traurig M, Chen P, Hsueh WC, Hanson RL, Piaggi P, Baier LJ., Free PMC Article | 06/9/2023 |
| LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer. | LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer.
Casarotto M, Lupato V, Giurato G, Guerrieri R, Sulfaro S, Salvati A, D'Angelo E, Furlan C, Menegaldo A, Baboci L, Montico B, Turturici I, Dolcetti R, Romeo S, Baggio V, Corrado S, Businello G, Guido M, Weisz A, Giacomarra V, Franchin G, Steffan A, Sigalotti L, Vaccher E, Boscolo-Rizzo P, Jerry P, Fanetti G, Fratta E., Free PMC Article | 01/11/2023 |
| The differential expression of long interspersed nuclear elements-1 as a marker for hypomethylation in Merkel cell carcinoma. | The differential expression of long interspersed nuclear elements-1 as a marker for hypomethylation in Merkel cell carcinoma.
Kuriyama Y, Shimizu A, Kim J, Yasuda M, Motegi SI. | 10/22/2022 |
| Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth. | Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth.
Barišić A, Stanković A, Stojković L, Pereza N, Ostojić S, Peterlin A, Peterlin B, Vraneković J. | 05/14/2022 |
| LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint. | LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint.
McKerrow W, Wang X, Mendez-Dorantes C, Mita P, Cao S, Grivainis M, Ding L, LaCava J, Burns KH, Boeke JD, Fenyö D., Free PMC Article | 03/19/2022 |
| MxB inhibits long interspersed element type 1 retrotransposition. | MxB inhibits long interspersed element type 1 retrotransposition.
Huang Y, Xu F, Mei S, Liu X, Zhao F, Wei L, Fan Z, Hu Y, Wang L, Ai B, Cen S, Liang C, Guo F., Free PMC Article | 02/26/2022 |
| Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease. | Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease.
Miller I, Totrov M, Korotchkina L, Kazyulkin DN, Gudkov AV, Korolev S., Free PMC Article | 12/25/2021 |
| The Rhox gene cluster suppresses germline LINE1 transposition. | The Rhox gene cluster suppresses germline LINE1 transposition.
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF., Free PMC Article | 12/11/2021 |
| Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells. | Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells.
Schöbel A, Nguyen-Dinh V, Schumann GG, Herker E., Free PMC Article | 08/28/2021 |
| Study results identify increased expression of L1TD1 as a prognostic marker predicting longer disease-free survival in colon cancer patients. | L1TD1 - a prognostic marker for colon cancer.
Chakroborty D, Emani MR, Klén R, Böckelman C, Hagström J, Haglund C, Ristimäki A, Lahesmaa R, Elo LL., Free PMC Article | 02/15/2020 |
| this study shows that LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways | LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.
Zhao K, Du J, Peng Y, Li P, Wang S, Wang Y, Hou J, Kang J, Zheng W, Hua S, Yu XF. | 06/29/2019 |
| The authors propose a model in which RNase H2 degrades the LINE-1 RNA after reverse transcription, allowing retrotransposition to be completed. This also explains how LINE-1 elements can retrotranspose efficiently without their own RNase H activity. | RNase H2, mutated in Aicardi-Goutières syndrome, promotes LINE-1 retrotransposition.
Benitez-Guijarro M, Lopez-Ruiz C, Tarnauskaitė Ž, Murina O, Mian Mohammad M, Williams TC, Fluteau A, Sanchez L, Vilar-Astasio R, Garcia-Canadas M, Cano D, Kempen MH, Sanchez-Pozo A, Heras SR, Jackson AP, Reijns MA, Garcia-Perez JL., Free PMC Article | 04/20/2019 |
| SPAG6 and L1TD1 are tumor-specifically methylated in NSCLCs and that DNA methylation is involved in the transcriptional regulation of these genes. Moreover, in vitro as well as in vivo experiments revealed tumor-cell growth suppressing properties of L1TD1 in NSCLC cells. | SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers.
Altenberger C, Heller G, Ziegler B, Tomasich E, Marhold M, Topakian T, Müllauer L, Heffeter P, Lang G, End-Pfützenreuter A, Döme B, Arns BM, Klepetko W, Zielinski CC, Zöchbauer-Müller S., Free PMC Article | 07/29/2017 |
| L1TD1 depletion reduced medulloblastoma cell viability, cell proliferation, downregulated expression of the neural stem cell markers and induced apoptosis. | Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in Medulloblastoma.
Santos MC, Silva PB, Rodini CO, Furukawa G, Marco Antonio DS, Zanotto-Filho A, Moreira JC, Okamoto OK. | 08/27/2016 |
| we show that L1TD1 is a part of the pluripotency interactome network of OCT4, SOX2, and NANOG, bridging nuclear and cytoplasmic regulation and highlighting the importance of RNA biology in pluripotency. | The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency.
Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R., Free PMC Article | 01/16/2016 |
| L1TD1 may have become incorporated into pluripotency maintenance in some lineages. | Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency.
McLaughlin RN Jr, Young JM, Yang L, Neme R, Wichman HA, Malik HS., Free PMC Article | 11/7/2015 |
| LINE-1 methylation was evaluated, a statistical difference was seen amongst groups and a slight hypomethylated state in the AgP samples was observed. | DNA methylation levels of SOCS1 and LINE-1 in oral epithelial cells from aggressive periodontitis patients.
Baptista NB, Portinho D, Casarin RC, Vale HF, Casati MZ, De Souza AP, Andia DC. | 01/17/2015 |
| LINE-1 hypomethylation in gastric cancer is associated with shorter survival, suggesting that it has potential for use as a prognostic biomarker. | LINE-1 hypomethylation in gastric cancer, detected by bisulfite pyrosequencing, is associated with poor prognosis.
Shigaki H, Baba Y, Watanabe M, Murata A, Iwagami S, Miyake K, Ishimoto T, Iwatsuki M, Baba H., Free PMC Article | 05/24/2014 |
| Paternal methylation aberrations at imprinting control regions of DLK1-GTL2, MEST (PEG1), and ZAC (PLAGL1) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages. | Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurrent spontaneous miscarriages.
Ankolkar M, Salvi V, Warke H, Vundinti BR, Balasinor NH. | 07/6/2013 |
| L1TD1 is part of the L1TD1-RHA-LIN28 complex that could influence levels of OCT4, suggesting that L1TD1 has an important role in the regulation of stemness. | RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation.
Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R., Free PMC Article | 06/16/2012 |
| there was no significant association of LINE-1 methylation with case status, although reduced LINE-1 methylation was associated with increased risk of bladder cancer among never smokers | LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese.
Cash HL, Tao L, Yuan JM, Marsit CJ, Houseman EA, Xiang YB, Gao YT, Nelson HH, Kelsey KT., Free PMC Article | 02/11/2012 |
| L1TD1 is a downstream target of Nanog and represents a useful marker for identifying undifferentiated hESC | L1TD1 is a marker for undifferentiated human embryonic stem cells.
Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ., Free PMC Article | 12/3/2011 |
| LINE-1 hypomethylation is significantly associated with CpG island hypermethylation in EF+ gastritis. | LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.
Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y. | 01/21/2010 |