| Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects. | Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects.
de Araújo JLF, Bonifácio VF, Batista LM, de Ávila RE, Aguiar RS, Bastos-Rodrigues L, de Souza RP. | 08/16/2023 |
| LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway. | LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway.
Lu J, Fu LM, Cao Y, Fang Y, Cao JZ, Pan YH, Cen JJ, Liang YP, Chen ZH, Wei JH, Huang Y, Mumin MA, Xu QH, Wang YH, Zhu JQ, Liang H, Wang Z, Deng Q, Chen W, Jin XH, Liu ZP, Luo JH., Free PMC Article | 05/12/2023 |
| Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19. | Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19.
Rüter J, Pallerla SR, Meyer CG, Casadei N, Sonnabend M, Peter S, Nurjadi D, Linh LTK, Fendel R, Göpel S, Riess O, Kremsner PG, Velavan TP., Free PMC Article | 09/17/2022 |
| CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1. | CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1.
Fink-Baldauf IM, Stuart WD, Brewington JJ, Guo M, Maeda Y., Free PMC Article | 02/5/2022 |
| lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization. | lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
Wang H, Ma P, Liu P, Guo D, Liu Z, Zhang Z. | 01/8/2022 |
| Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus. | Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.
Downes DJ, Cross AR, Hua P, Roberts N, Schwessinger R, Cutler AJ, Munis AM, Brown J, Mielczarek O, de Andrea CE, Melero I, COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium, Gill DR, Hyde SC, Knight JC, Todd JA, Sansom SN, Issa F, Davies JOJ, Hughes JR., Free PMC Article | 11/27/2021 |
| Limited time window for retinal gene therapy in a preclinical model of ciliopathy. | Limited time window for retinal gene therapy in a preclinical model of ciliopathy.
Datta P, Ruffcorn A, Seo S., Free PMC Article | 08/21/2021 |
| LZTFL1 was identified as a novel target gene of miR-21. Knockdown of LZTFL1 overcame the suppression of miR-21 inhibitor on cell proliferation, metastasis and the expression of epithelial-mesenchymal transition markers in breast cancer cells. | microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1.
Wang H, Tan Z, Hu H, Liu H, Wu T, Zheng C, Wang X, Luo Z, Wang J, Liu S, Lu Z, Tu J., Free PMC Article | 01/4/2020 |
| LZTFL1 inhibits lung tumorigenesis | LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells.
Wei Q, Chen ZH, Wang L, Zhang T, Duan L, Behrens C, Wistuba II, Minna JD, Gao B, Luo JH, Liu ZP., Free PMC Article | 09/9/2017 |
| these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. | LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 Production.
Jiang H, Promchan K, Lin BR, Lockett S, Chen D, Marshall H, Badralmaa Y, Natarajan V., Free PMC Article | 06/11/2016 |
| LZTFL1 binds beta-catenin in the cytoplasm of the cell and inhibited its nuclear translocation | LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of β-catenin.
Wang L, Guo J, Wang Q, Zhou J, Xu C, Teng R, Chen Y, Wei Q, Liu ZP. | 02/28/2015 |
| This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17). | Mesoaxial polydactyly is a major feature in Bardet-Biedl syndrome patients with LZTFL1 (BBS17) mutations.
Schaefer E, Lauer J, Durand M, Pelletier V, Obringer C, Claussmann A, Braun JJ, Redin C, Mathis C, Muller J, Schmidt-Mutter C, Flori E, Marion V, Stoetzel C, Dollfus H. | 11/22/2014 |
| The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17). | Exome sequencing identifies mutations in LZTFL1, a BBSome and smoothened trafficking regulator, in a family with Bardet--Biedl syndrome with situs inversus and insertional polydactyly.
Marion V, Stutzmann F, Gérard M, De Melo C, Schaefer E, Claussmann A, Hellé S, Delague V, Souied E, Barrey C, Verloes A, Stoetzel C, Dollfus H. | 11/24/2012 |
| Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling | A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
Seo S, Zhang Q, Bugge K, Breslow DK, Searby CC, Nachury MV, Sheffield VC., Free PMC Article | 02/25/2012 |
| LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. | Tumor-suppressive functions of leucine zipper transcription factor-like 1.
Wei Q, Zhou W, Wang W, Gao B, Wang L, Cao J, Liu ZP., Free PMC Article | 05/10/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |