| RTP801 interacts with the tRNA ligase complex and dysregulates its RNA ligase activity in Alzheimer's disease. | RTP801 interacts with the tRNA ligase complex and dysregulates its RNA ligase activity in Alzheimer's disease.
Campoy-Campos G, Solana-Balaguer J, Guisado-Corcoll A, Chicote-González A, Garcia-Segura P, Pérez-Sisqués L, Torres AG, Canal M, Molina-Porcel L, Fernández-Irigoyen J, Santamaria E, Ribas de Pouplana L, Alberch J, Martí E, Giralt A, Pérez-Navarro E, Malagelada C., Free PMC Article | 10/16/2024 |
| NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3beta. | NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β.
McCurry CM, Sunilkumar S, Subrahmanian SM, Yerlikaya EI, Toro AL, VanCleave AM, Stevens SA, Barber AJ, Sundstrom JM, Dennis MD., Free PMC Article | 04/2/2024 |
| Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia. | Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia.
Li F, Miao J, Liu R, Zhang R, He A., Free PMC Article | 03/22/2024 |
| Nuclear overexpression of DNA damage-inducible transcript 4 (DDIT4) is associated with aggressive tumor behavior in patients with pancreatic tumors. | Nuclear overexpression of DNA damage-inducible transcript 4 (DDIT4) is associated with aggressive tumor behavior in patients with pancreatic tumors.
Tajik F, Fattahi F, Rezagholizadeh F, Bouzari B, Babaheidarian P, Baghai Wadji M, Madjd Z., Free PMC Article | 11/14/2023 |
| REDD1 (regulated in development and DNA damage 1) modulates the glucocorticoid receptor function in keratinocytes. | REDD1 (regulated in development and DNA damage 1) modulates the glucocorticoid receptor function in keratinocytes.
Chudakova DA, Trubetskoy D, Baida G, Bhalla P, Readhead B, Budunova I. | 10/12/2023 |
| DDIT4 Facilitates Lymph Node Metastasis via the Activation of NF-kappaB Pathway and Epithelial-Mesenchymal Transition. | DDIT4 Facilitates Lymph Node Metastasis via the Activation of NF-κB Pathway and Epithelial-Mesenchymal Transition.
Lin X, Yoshikawa N, Liu W, Matsukawa T, Nakamura K, Yoshihara M, Koya Y, Sugiyama M, Tamauchi S, Ikeda Y, Yokoi A, Shimizu Y, Kajiyama H. | 09/8/2023 |
| REDD1-dependent GSK3beta dephosphorylation promotes NF-kappaB activation and macrophage infiltration in the retina of diabetic mice. | REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice.
Sunilkumar S, VanCleave AM, McCurry CM, Toro AL, Stevens SA, Kimball SR, Dennis MD., Free PMC Article | 08/31/2023 |
| DDIT4 promotes malignancy of head and neck squamous cell carcinoma. | DDIT4 promotes malignancy of head and neck squamous cell carcinoma.
Zhang Z, Zhu H, Zhao C, Liu D, Luo J, Ying Y, Zhong Y. | 02/28/2023 |
| PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice. | PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice.
Stevens SA, Gonzalez Aguiar MK, Toro AL, Yerlikaya EI, Sunilkumar S, VanCleave AM, Pfleger J, Bradley EA, Kimball SR, Dennis MD., Free PMC Article | 01/28/2023 |
| REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice. | REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice.
Sunilkumar S, Yerlikaya EI, Toro AL, Miller WP, Chen H, Hu K, Kimball SR, Dennis MD., Free PMC Article | 10/29/2022 |
| Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe? | Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?
Zhidkova EM, Lylova ES, Grigoreva DD, Kirsanov KI, Osipova AV, Kulikov EP, Mertsalov SA, Belitsky GA, Budunova I, Yakubovskaya MG, Lesovaya EA., Free PMC Article | 09/24/2022 |
| REDD1 interacts with AIF and regulates mitochondrial reactive oxygen species generation in the keratinocyte response to UVB. | REDD1 interacts with AIF and regulates mitochondrial reactive oxygen species generation in the keratinocyte response to UVB.
Feehan RP, Coleman CS, Ebanks S, Lang CH, Shantz LM. | 06/25/2022 |
| DDIT4 S-Nitrosylation Aids p38-MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production. | DDIT4 S-Nitrosylation Aids p38-MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production.
Li Z, Zhao Q, Lu Y, Zhang Y, Li L, Li M, Chen X, Sun D, Duan Y, Xu Y., Free PMC Article | 02/12/2022 |
| Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism. | Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism.
Chaves AB, Miranda ER, Mey JT, Blackburn BK, Fuller KNZ, Stearns B, Ludlow A, Williamson DL 4th, Houmard JA, Haus JM., Free PMC Article | 02/5/2022 |
| Helicobacter pylori-induced REDD1 modulates Th17 cell responses that contribute to gastritis. | Helicobacter pylori-induced REDD1 modulates Th17 cell responses that contribute to gastritis.
Yan ZB, Zhang JY, Lv YP, Tian WQ, Shan ZG, Mao FY, Liu YG, Chen WY, Wang P, Yang Y, Cheng P, Peng LS, Liao YL, Yue GY, Xu XL, Zhao YL, Lü MH, Zhuang Y. | 12/11/2021 |
| REDD1 attenuates hepatic stellate cell activation and liver fibrosis via inhibiting of TGF-beta/Smad signaling pathway. | REDD1 attenuates hepatic stellate cell activation and liver fibrosis via inhibiting of TGF-β/Smad signaling pathway.
Cho SS, Lee JH, Kim KM, Park EY, Ku SK, Cho IJ, Yang JH, Ki SH. | 12/11/2021 |
| RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease. | RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease.
Pérez-Sisqués L, Sancho-Balsells A, Solana-Balaguer J, Campoy-Campos G, Vives-Isern M, Soler-Palazón F, Anglada-Huguet M, López-Toledano MÁ, Mandelkow EM, Alberch J, Giralt A, Malagelada C., Free PMC Article | 11/6/2021 |
| High expression of DNA damage-inducible transcript 4 (DDIT4) is associated with advanced pathological features in the patients with colorectal cancer. | High expression of DNA damage-inducible transcript 4 (DDIT4) is associated with advanced pathological features in the patients with colorectal cancer.
Fattahi F, Saeednejad Zanjani L, Habibi Shams Z, Kiani J, Mehrazma M, Najafi M, Madjd Z., Free PMC Article | 11/6/2021 |
| The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy. | The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy.
Miller WP, Sunilkumar S, Dennis MD., Free PMC Article | 09/4/2021 |
| A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas. | A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas.
Ho KH, Chen PH, Chou CM, Shih CM, Lee YT, Cheng CH, Chen KC., Free PMC Article | 09/4/2021 |
| LncRNA PSMB8-AS1 acts as ceRNA of miR-22-3p to regulate DDIT4 expression in glioblastoma. | LncRNA PSMB8-AS1 acts as ceRNA of miR-22-3p to regulate DDIT4 expression in glioblastoma.
Hu T, Wang F, Han G. | 05/22/2021 |
| Up-regulation of DDIT4 predicts poor prognosis in acute myeloid leukaemia. | Up-regulation of DDIT4 predicts poor prognosis in acute myeloid leukaemia.
Cheng Z, Dai Y, Pang Y, Jiao Y, Liu Y, Cui L, Quan L, Qian T, Zeng T, Si C, Huang W, Chen J, Pang Y, Ye X, Shi J, Fu L., Free PMC Article | 05/8/2021 |
| Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease. | Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease.
Martín-Flores N, Pérez-Sisqués L, Creus-Muncunill J, Masana M, Ginés S, Alberch J, Pérez-Navarro E, Malagelada C., Free PMC Article | 03/27/2021 |
| Is REDD1 a metabolic double agent? Lessons from physiology and pathology. | Is REDD1 a metabolic double agent? Lessons from physiology and pathology.
Britto FA, Dumas K, Giorgetti-Peraldi S, Ollendorff V, Favier FB. | 12/19/2020 |
| Loss of heterozygosity for Kras(G12D) promotes REDD1-dependent, non-canonical glutamine metabolism in pancreatic ductal adenocarcinoma. | Loss of heterozygosity for Kras(G12D) promotes REDD1-dependent, non-canonical glutamine metabolism in pancreatic ductal adenocarcinoma.
Ma Y, Li Y, Ling S, Li X, Kong B, Hu M, Huang P. | 11/28/2020 |