| Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules. | Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.
Condello V, Poma AM, Macerola E, Vignali P, Paulsson JO, Zedenius J, Basolo F, Juhlin CC., Free PMC Article | 07/1/2024 |
| The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8. | The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.
Li Y, Carey TS, Feng CH, Zhu HM, Sun XX, Dai MS., Free PMC Article | 08/9/2023 |
| Splice site m[6]A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. | Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.
Li X, Fang J, Tao X, Xia J, Cheng B, Wang Y., Free PMC Article | 02/28/2023 |
| METTL3 contributes to slow transit constipation by regulating miR-30b-5p/PIK3R2/Akt/mTOR signaling cascade through DGCR8. | METTL3 contributes to slow transit constipation by regulating miR-30b-5p/PIK3R2/Akt/mTOR signaling cascade through DGCR8.
Gong WJ, Li R, Dai QQ, Yu P. | 12/24/2022 |
| Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene. | Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene.
Reé D, Fóthi Á, Varga N, Kolacsek O, Orbán TI, Apáti Á., Free PMC Article | 11/19/2022 |
| Pathogenic noncoding variants in the neurofibromatosis and schwannomatosis predisposition genes. | Pathogenic noncoding variants in the neurofibromatosis and schwannomatosis predisposition genes.
Perez-Becerril C, Evans DG, Smith MJ. | 07/16/2022 |
| Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis. | Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis.
Lett KE, Logan MK, McLaurin DM, Hebert MD., Free PMC Article | 02/12/2022 |
| The orf virus (ORFV) protein OV20.0 interacts with the microprocessor complex subunit DGCR8 to regulate miRNA biogenesis and ORFV infection. | The orf virus (ORFV) protein OV20.0 interacts with the microprocessor complex subunit DGCR8 to regulate miRNA biogenesis and ORFV infection.
Liao GR, Tseng YY, Tseng CY, Lo CY, Hsu WL. | 01/1/2022 |
| Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8. | Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8.
Paulsson JO, Rafati N, DiLorenzo S, Chen Y, Haglund F, Zedenius J, Juhlin CC., Free PMC Article | 12/11/2021 |
| Molecular determinants that govern scaRNA processing by Drosha/DGCR8. | Molecular determinants that govern scaRNA processing by Drosha/DGCR8.
McLaurin DM, Logan MK, Lett KE, Hebert MD., Free PMC Article | 10/16/2021 |
| DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2. | DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2.
Nogami M, Miyamoto K, Hayakawa-Yano Y, Nakanishi A, Yano M, Okano H., Free PMC Article | 08/28/2021 |
| Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. | Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance.
Hang Q, Zeng L, Wang L, Nie L, Yao F, Teng H, Deng Y, Yap S, Sun Y, Frank SJ, Chen J, Ma L., Free PMC Article | 07/24/2021 |
| Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8. | Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8.
de Kock L, Rivera B, Foulkes WD. | 06/12/2021 |
| STAT5A induced LINC01198 promotes proliferation of glioma cells through stabilizing DGCR8. | STAT5A induced LINC01198 promotes proliferation of glioma cells through stabilizing DGCR8.
Tan C, Dai Y, Liu X, Zhao G, Wang W, Li J, Qi L., Free PMC Article | 05/15/2021 |
| DGCR8 promotes the metastasis in triple-negative breast cancer by epigenetically regulating TGF-beta. | DGCR8 promotes the metastasis in triple-negative breast cancer by epigenetically regulating TGF-β.
Cui CY, Pan QW, Wang MH, Ai X, Yan YZ, Tian Y, Jin YT, Tang P, Jiang J, Ren ZX. | 03/20/2021 |
| Circ PSMC3 inhibits prostate cancer cell proliferation by downregulating DGCR8. | Circ PSMC3 inhibits prostate cancer cell proliferation by downregulating DGCR8.
Dong JS, Wu B, Chen XH. | 03/20/2021 |
| Long noncoding RNA SNHG14 enhances migration and invasion of ovarian cancer by upregulating DGCR8. | Long noncoding RNA SNHG14 enhances migration and invasion of ovarian cancer by upregulating DGCR8.
Zhao JL, Wang CL, Liu YL, Zhang GY. | 11/21/2020 |
| ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8. | ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8.
Kwon SC, Jang H, Shen S, Baek SC, Kim K, Yang J, Kim J, Kim JS, Wang S, Shi Y, Li F, Kim VN., Free PMC Article | 11/21/2020 |
| DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis. | DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis.
Rivera B, Nadaf J, Fahiminiya S, Apellaniz-Ruiz M, Saskin A, Chong AS, Sharma S, Wagener R, Revil T, Condello V, Harra Z, Hamel N, Sabbaghian N, Muchantef K, Thomas C, de Kock L, Hébert-Blouin MN, Bassenden AV, Rabenstein H, Mete O, Paschke R, Pusztaszeri MP, Paulus W, Berghuis A, Ragoussis J, Nikiforov YE, Siebert R, Albrecht S, Turcotte R, Hasselblatt M, Fabian MR, Foulkes WD., Free PMC Article | 11/21/2020 |
| Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. | Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.
Partin AC, Zhang K, Jeong BC, Herrell E, Li S, Chiu W, Nam Y., Free PMC Article | 08/29/2020 |
| Structural Basis for pri-miRNA Recognition by Drosha. | Structural Basis for pri-miRNA Recognition by Drosha.
Jin W, Wang J, Liu CP, Wang HW, Xu RM. | 08/29/2020 |
| Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci. | Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci.
Shang R, Baek SC, Kim K, Kim B, Kim VN, Lai EC., Free PMC Article | 08/15/2020 |
| Microprocessor is a trimeric protein complex, which is composed of an RNase III enzyme, DROSHA, and DGCR8; its processing of primary microRNA is governed by mismatched and wobble pairs | Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor.
Li S, Nguyen TD, Nguyen TL, Nguyen TA., Free PMC Article | 08/12/2020 |
| the internal loop located in the lower stem of numerous pri-miRNAs selectively inhibits the cleavage of Microprocessor on their 3p-strand, thereby, facilitating the single cleavage on their 5p-strand. | The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor.
Nguyen TL, Nguyen TD, Bao S, Li S, Nguyen TA., Free PMC Article | 05/23/2020 |
| Study observed that mRNA expression levels of Drosha, Dicer, and DGCR8 were significantly upregulated in gastric cancer tumoral tissues compared with marginal tissues. Upregulation of these genes was not correlated with clinical manifestations of the patients. Upregulation of Drosha, Dicer, and DGCR8 plays a role in the development of cancer, probably through dysregulated the expression level of miRNAs. | Transcript Level of MicroRNA Processing Elements in Gastric Cancer.
Asadi M, Shanehbandi D, Zafari V, Khaze V, Somi MH, Hashemzadeh S. | 05/9/2020 |