| Ischemia/reperfusion-induced MiD51 upregulation recruits Drp1 to mitochondria and contributes to myocardial injury. | Ischemia/reperfusion-induced MiD51 upregulation recruits Drp1 to mitochondria and contributes to myocardial injury.
Gao T, Shi R, Liu Z, De D, Li R, Chen Y, Pei J, Ding M. | 06/13/2023 |
| Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics. | Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics.
Wong YC, Kim S, Cisneros J, Molakal CG, Song P, Lubbe SJ, Krainc D., Free PMC Article | 09/10/2022 |
| Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy. | Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy.
Charif M, Wong YC, Kim S, Guichet A, Vignal C, Zanlonghi X, Bensaid P, Procaccio V, Bonneau D, Amati-Bonneau P, Reynier P, Krainc D, Lenaers G., Free PMC Article | 11/6/2021 |
| An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications. | An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Dasgupta A, Chen KH, Wu D, Hoskin V, Mewburn J, Lima PDA, Parlow LRG, Hindmarch CCT, Martin A, Sykes EA, Tayade C, Lightbody ED, Madarnas Y, SenGupta SK, Elliott BE, Nicol CJB, Archer SL. | 01/23/2021 |
| The study uncovers a bridging role of MIEF1 integrating cell death and mitophagy, unlikely dependent on mitochondrial dynamics, implying new insights to mechanisms determining cellular fate. | Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Xian H, Liou YC., Free PMC Article | 07/18/2020 |
| We found that the receptors mitochondrial fission factor (Mff) and mitochondrial elongation factor 1/2 (MIEF1/2) interact with and recruit Drp1(pS637) to mitochondria and that elevated Mff or MIEF levels promote Drp1(pS637) accumulation on mitochondria. We also noted that protein kinase A (PKA), which mediates phosphorylation of Drp1 on Ser-637, is partially present on mitochondria and interacts with both MIEFs and Mff | The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria.
Yu R, Liu T, Ning C, Tan F, Jin SB, Lendahl U, Zhao J, Nistér M., Free PMC Article | 06/13/2020 |
| In health, MiD51 regulate Drp1-mediated fission, whereas in disease, epigenetic upregulation of MiD51 increases mitotic fission, which drives pathological proliferation and apoptosis resistance | Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.
Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary K, Theilmann AL, Jing ZC, Hindmarch C, Ormiston ML, Lawrie A, Archer SL., Free PMC Article | 10/5/2019 |
| Loss of mitochondrial elongation factor 1 microprotein (MIEF1-MP) decreases the mitochondrial translation rate, while an elevated level of MIEF1-MP increases the translation rate | MIEF1 Microprotein Regulates Mitochondrial Translation.
Rathore A, Chu Q, Tan D, Martinez TF, Donaldson CJ, Diedrich JK, Yates JR 3rd, Saghatelian A., Free PMC Article | 07/13/2019 |
| MiD51 inhibits Drp1, whereas ADP promotes MiD51-mediated fission. [review] | The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease.
Atkins K, Dasgupta A, Chen KH, Mewburn J, Archer SL. | 07/8/2017 |
| The results indicate that Drp1-dependent mitochondrial fission through MiD49/MiD51 regulates cristae remodeling during intrinsic apoptosis. | Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling.
Otera H, Miyata N, Kuge O, Mihara K., Free PMC Article | 07/16/2016 |
| The cytoplasmic domain of MiD51 was overexpressed, purified and crystallized. | Expression, purification, crystallization and preliminary crystallographic study of the cytoplasmic domain of the mitochondrial dynamics protein MiD51.
Ma J, Sun F., Free PMC Article | 01/31/2015 |
| MIEF1 and MIEF2 are differentially expressed in human tissues during development | The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics.
Liu T, Yu R, Jin SB, Han L, Lendahl U, Zhao J, Nistér M. | 12/28/2013 |
| MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria. | Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.
Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT., Free PMC Article | 11/30/2013 |
| we find that either MiD49 or MiD51 can mediate Drp1 recruitment and mitochondrial fission in the absence of Fis1 and Mff | Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
Losón OC, Song Z, Chen H, Chan DC., Free PMC Article | 09/14/2013 |
| elevated MIEF1 levels induce mitochondrial fusion; depletion of MIEF1 causes mitochondrial fragmentation; MIEF1 interacts with and recruits Drp1 to mitochondria but inhibits Drp1 activity, executing a negative effect on mitochondrial fission | Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission.
Zhao J, Liu T, Jin S, Wang X, Qu M, Uhlén P, Tomilin N, Shupliakov O, Lendahl U, Nistér M., Free PMC Article | 10/1/2011 |
| MiD49/51 are new mediators of mitochondrial division affecting Drp1 action at mitochondria. | MiD49 and MiD51, new components of the mitochondrial fission machinery.
Palmer CS, Osellame LD, Laine D, Koutsopoulos OS, Frazier AE, Ryan MT, Palmer CS, Osellame LD, Laine D, Koutsopoulos OS, Frazier AE, Ryan MT., Free PMC Articles: PMC3128275, PMC3128275 | 09/17/2011 |
| Mitochondrial outer membrane protein that recruits fission mediator Drp1 to the mitochondrial surface. | MiD49 and MiD51, new components of the mitochondrial fission machinery.
Palmer CS, Osellame LD, Laine D, Koutsopoulos OS, Frazier AE, Ryan MT, Palmer CS, Osellame LD, Laine D, Koutsopoulos OS, Frazier AE, Ryan MT., Free PMC Articles: PMC3128275, PMC3128275 | 06/28/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |