| Altered HDL proteome predicts incident CVD in chronic kidney disease patients. | Altered HDL proteome predicts incident CVD in chronic kidney disease patients.
Shao B, Mathew AV, Thornock C, Pennathur S, Michigan Kidney Translational Core CPROBE Investigator Group., Free PMC Article | 03/26/2022 |
| Serum paraoxonase 1 and 3 activities in benign and malignant diseases of the prostate and changes in levels following robotic-assisted laparoscopic radical prostatectomy | Serum paraoxonase 1 and 3 activities in benign and malignant diseases of the prostate and changes in levels following robotic-assisted laparoscopic radical prostatectomy.
Bedir F, Kocatürk H, Altay MS, Şebin E, Bedir B., Free PMC Article | 10/16/2021 |
| Micro- and macrovascular cardiac allograft vasculopathy in relation to 91 cardiovascular biomarkers in heart transplant recipients-An exploratory study. | Micro- and macrovascular cardiac allograft vasculopathy in relation to 91 cardiovascular biomarkers in heart transplant recipients-An exploratory study.
Bjerre KP, Clemmensen TS, Poulsen SH, Hvas AM, Holm NR, Grove EL, Bouchelouche K, Kristensen SD, Eiskjaer H. | 08/28/2021 |
| Paraoxonase 3 gene polymorphisms are associated with occupational noise-induced deafness: A matched case-control study from China. | Paraoxonase 3 gene polymorphisms are associated with occupational noise-induced deafness: A matched case-control study from China.
Zhou H, Zhou J, Li H, Hui C, Bi J., Free PMC Article | 12/12/2020 |
| Paraoxonase 3: Structure and Its Role in Pathophysiology of Coronary Artery Disease. | Paraoxonase 3: Structure and Its Role in Pathophysiology of Coronary Artery Disease.
Priyanka K, Singh S, Gill K., Free PMC Article | 09/26/2020 |
| PON1 and PON3 promoter methylation levels in peripheral blood were closely related. PON1 and PON3 methylation were associated with the risk of cerebral infarction in men. | PON1 Hypermethylation and PON3 Hypomethylation are Associated with Risk of Cerebral Infarction.
Xiao J, Li X, Yuan Q, Zhang S, Qu K, Wu B, Wang Y, Duan S. | 07/11/2020 |
| No significant differences were observed between PON2 and PON3 gene expression in psoriatic lesional and non lesional skin compared with healthy controls | Paraoxonases and psoriasis: negative imbalance of antioxidant endogenous mechanisms.
Schiattarella M, Caiazzo G, Di Caprio R, Lembo S, Raimondo A, Ayala F, Balato N, Monfrecola G, Fortunato G, Balato A. | 06/22/2019 |
| In donor retina from patients with diabetes, all three PON1, PON2 and PON3 were expressed, and there was a significant increase in PON3 expression compared to control. This might be the reason for the increased thiolactonase activity observed in diabetic retina compared to control | Ocular distribution of antioxidant enzyme paraoxonase & its alteration in cataractous lens & diabetic retina.
Bharathidevi SR, Babu KA, Jain N, Muthukumaran S, Umashankar V, Biswas J, Angayarkanni N., Free PMC Article | 05/5/2018 |
| PON3 suppressed cell proliferation in vivo and in vitro, which was attributed to its cell-cycle arrest effect. | Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma.
Cai J, Yuan SX, Yang F, Tao QF, Yang Y, Xu QG, Wang ZG, Yu J, Lin KY, Wang ZY, Ma JZ, Zhou CC, Wang F, Sun SH, Zhou WP., Free PMC Article | 02/24/2018 |
| PON3 protein can be detected in plasma and resides in the high-density lipoprotein fraction and protects against Oxidative stress by hydrolyzing certain oxidized lipids in lipoproteins, macrophages and Atherosclerotic lesions. | [Paraoxonase: The Universal Factor of Antioxidant Defense in Human Body].
Borovkova EI, Antipova NV, Komeenko TV, Shakhparonov MI, Borovkov IM. | 02/24/2018 |
| Our study showed that although lipoic acid up-regulates PON3 but down-regulates PON1 mRNA expression, it increases both PON1 and PON3 protein levels and arylesterase activity in HepG2 cells. We can report that lipoic acid may be useful for preventing atherosclerosis at therapeutic doses. | Effect of lipoic acid on paraoxonase-1 and paraoxonase-3 protein levels, mRNA expression and arylesterase activity in liver hepatoma cells.
Ozgun E, Sayilan Ozgun G, Tabakcioglu K, Suer Gokmen S, Sut N, Eskiocak S. | 11/25/2017 |
| Data suggest that paraoxonases (PON1, PON2, PON3) play roles in innate immunity, inflammatory response, and protection against oxidative stress; these factors are associated with the body's response to infectious diseases; low serum PON1 activities are associated with poor survival in patients with severe sepsis. [REVIEW] | Paraoxonases and infectious diseases.
Camps J, Iftimie S, García-Heredia A, Castro A, Joven J. | 08/19/2017 |
| Data show that the mRNA levels of both paraoxonases PON2 and PON3 were significantly upregulated whereas PON1's mRNA was absent in transgenic mouse hearts. | Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice.
Pei JF, Yan YF, Tang X, Zhang Y, Cui SS, Zhang ZQ, Chen HZ, Liu DP. | 07/1/2017 |
| Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4, PON3, STAT5a, and VAX2 gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumor | Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer.
Kitchen MO, Bryan RT, Emes RD, Glossop JR, Luscombe C, Cheng KK, Zeegers MP, James ND, Devall AJ, Mein CA, Gommersall L, Fryer AA, Farrell WE., Free PMC Article | 05/27/2017 |
| Low PON3 expression is associated with hepatocellular carcinoma progression. | Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis.
Jin Y, Li Q, Qiu J, Zhao X, Zheng C, Lv S, Bai Y, Shan Y, Ye LC. | 03/4/2017 |
| This study showed that the PI3K/Akt pathway is up-regulated by the expression of PON3 in oral squamous cell carcinoma by AP-1. | Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oral squamous cell carcinoma.
Zhu L, Shen Y, Sun W. | 02/18/2017 |
| Studies indicate that three paraoxonases PON1, PON2, and PON3 genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties. | Paraoxonase and atherosclerosis-related cardiovascular diseases.
Chistiakov DA, Melnichenko AA, Orekhov AN, Bobryshev YV. | 02/4/2017 |
| PON3 SNP rs13226149 was associated with intracerebral hemorrhage in log-additive and dominant models. The A allele of rs13226149 contributed to the decreased risk of ICH. SNP rs1053275 was not associated with ICH. | Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.
Park HJ, Kim SK, Park HK, Chung JH. | 08/13/2016 |
| Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1, PON2, PON3) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL level in blood. [REVIEW] | Paraoxonase activity as a marker of exposure to xenobiotics in tobacco smoke.
Milnerowicz H, Kowalska K, Socha E. | 03/5/2016 |
| Interaction of PON-3 and PON-1 and HDL are associated with the presence and severity of coronary artery disease in type 2 diabetes mellitus patients. | Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus.
Shen Y, Ding FH, Sun JT, Pu LJ, Zhang RY, Zhang Q, Chen QJ, Shen WF, Lu L., Free PMC Article | 02/6/2016 |
| PON3 in HDL may be an important protein in preventing atherosclerosis. | Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis.
Marsillach J, Becker JO, Vaisar T, Hahn BH, Brunzell JD, Furlong CE, de Boer IH, McMahon MA, Hoofnagle AN, DCCT/EDIC Research Group., Free PMC Article | 02/6/2016 |
| PON2 and PON3 (i) are associated with mitochondria and mitochondria-associated membranes, (ii) modulate mitochondria-dependent superoxide production, and (iii) prevent apoptosis. | Inflammation, infection, cancer and all that…the role of paraoxonases.
Devarajan A, Shih D, Reddy ST., Free PMC Article | 11/22/2014 |
| PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. | PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
Schweikert EM, Devarajan A, Witte I, Wilgenbus P, Amort J, Förstermann U, Shabazian A, Grijalva V, Shih DM, Farias-Eisner R, Teiber JF, Reddy ST, Horke S., Free PMC Article | 06/22/2013 |
| Our results suggest that low serum paraoxonase activity is a risk factor for Alzheimer disease. Furthermore, multiple variants in PON influence serum paraoxonase activity and their effects may be synergistic. | Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
Erlich PM, Lunetta KL, Cupples LA, Abraham CR, Green RC, Baldwin CT, Farrer LA., Free PMC Article | 11/24/2012 |
| Increased serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease. | Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease.
Rull A, García R, Fernández-Sender L, García-Heredia A, Aragonès G, Beltrán-Debón R, Marsillach J, Alegret JM, Martín-Paredero V, Mackness B, Mackness M, Joven J, Camps J. | 05/26/2012 |