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    POMC proopiomelanocortin [ Homo sapiens (human) ]

    Gene ID: 5443, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    An analysis of POMC gene methylation and expression in patients with schizophrenia.

    An analysis of POMC gene methylation and expression in patients with schizophrenia.
    Chen X, Qing L, Zou T, Wang J, Yin W, Wang Z, Cheng T, Lu Y, Hu L, Liu L, Nie S.

    05/23/2024
    Fluctuations in serum adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis.

    Fluctuations in plasma adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis.
    Bando H, Yamamoto M, Urai S, Motomura Y, Sasaki Y, Ohmachi Y, Kobatake M, Tsujimoto Y, Oi-Yo Y, Suzuki M, Yamamoto N, Takahashi M, Fukuoka H, Iguchi G, Ogawa W., Free PMC Article

    03/4/2024
    Angiographic cross-filling between inferior petrosal sinuses and alteration of adrenocorticotropic hormone sampling results for tumor localization in Cushing disease.

    Angiographic cross-filling between inferior petrosal sinuses and alteration of adrenocorticotropic hormone sampling results for tumor localization in Cushing disease.
    Martini ML, Ransom RC, Rechberger JS, O'Keeffe D, Young W, Atkinson JLD, Meyer FB, Rinaldo L, Carlstrom L, Cloft HJ, Van Gompel J.

    02/9/2024
    The role of breast milk beta-endorphin and relaxin-2 on infant colic.

    The role of breast milk beta-endorphin and relaxin-2 on infant colic.
    Doneray H, Tavlas G, Ozden A, Ozturk N.

    12/22/2023
    Proopiomelanocortin and its potential functions in the pathological synovium of patients with osteoarthritis.

    Proopiomelanocortin and its potential functions in the pathological synovium of patients with osteoarthritis.
    Du GW, Zhang FW, Gao WL, Yin ZS.

    11/3/2023
    Isolated autoimmune adrenocorticotropic hormone deficiency: A positive predictor of survival among cancer patients treated with checkpoint inhibitors.

    Isolated autoimmune adrenocorticotropic hormone deficiency: A positive predictor of survival among cancer patients treated with checkpoint inhibitors.
    Aviv-Shimoni S, Uri I, Milloh-Raz H, Percik R.

    09/6/2023
    Alpha-melanocyte stimulating hormone (alpha-MSH): biology, clinical relevance and implication in melanoma.

    Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma.
    Dall'Olmo L, Papa N, Surdo NC, Marigo I, Mocellin S., Free PMC Article

    08/30/2023
    Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use.

    Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use.
    Le Collen L, Delemer B, Poitou C, Vaxillaire M, Toussaint B, Dechaume A, Badreddine A, Boissel M, Derhourhi M, Clément K, Petit JM, Mau-Them FT, Bruel AL, Thauvin-Robinet C, Saveanu A, Cherifi BG, Le Beyec-Le Bihan J, Froguel P, Bonnefond A.

    07/24/2023
    Maternal glucose intolerance during pregnancy affects offspring POMC expression and results in adult metabolic alterations in a sex-dependent manner.

    Maternal glucose intolerance during pregnancy affects offspring POMC expression and results in adult metabolic alterations in a sex-dependent manner.
    Martins MG, Silver Z, Ayoub K, Hyland L, Woodside B, Kiss ACI, Abizaid A., Free PMC Article

    07/6/2023
    Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants.

    Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants.
    Shah BP, Sleiman PM, Mc Donald J, Moeller IH, Kleyn P.

    04/12/2023
    alpha-MSH as a potential biomarker of severity and prognosis after intracerebral hemorrhage: A prospective cohort study.

    α-MSH as a potential biomarker of severity and prognosis after intracerebral hemorrhage: A prospective cohort study.
    Hu Q, Wu X, Wang Z, Yan T, Wang L, Yu W, Du Q, Hu W, Zheng Y, Wang K, Dong X, Yang D.

    01/14/2023
    Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.

    Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
    Coppola I, Brouwers B, Walker L, Alar C, Meulemans S, White A, Ramos-Molina B, Creemers JWM., Free PMC Article

    01/14/2023
    Imbalance in functional and structural connectivity underlying goal-directed and habitual learning systems in obsessive-compulsive disorder.

    Imbalance in functional and structural connectivity underlying goal-directed and habitual learning systems in obsessive-compulsive disorder.
    Xu C, Hou G, He T, Ruan Z, Chen J, Wei Z, Seger CA, Chen Q, Peng Z.

    09/17/2022
    A Founder Mutation in the POMC 5'-UTR Causes Proopiomelanocortin Deficiency Through Splicing-Mediated Decrease of mRNA.

    A Founder Mutation in the POMC 5'-UTR Causes Proopiomelanocortin Deficiency Through Splicing-Mediated Decrease of mRNA.
    Viakhireva I, Kalinchenko N, Vasilyev E, Chistousova GV, Filatova A, Marakhonov A, Rubtsov PM, Skoblov M, Tiulpakov A.

    08/27/2022
    Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant.

    Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant.
    van der Valk ES, Kleinendorst L, Delhanty PJD, van der Voorn B, Visser JA, van Haelst MM, de Graaff LCG, Huisman M, White A, Ito S, Wakamatsu K, de Rijke YB, van den Akker ELT, Iyer AM, van Rossum EFC., Free PMC Article

    08/27/2022
    Gene expression and methylation profiles show the involvement of POMC in primary hyperparathyroidsm.

    Gene expression and methylation profiles show the involvement of POMC in primary hyperparathyroidsm.
    Zhou WX, Wang S, Wu TC, Cheng LC, Du Y, Wu W, Lin C, Li XY, Hu ZL., Free PMC Article

    08/27/2022
    Single-cell RNA sequencing in silent corticotroph tumors confirms impaired POMC processing and provides new insights into their invasive behavior.

    Single-cell RNA sequencing in silent corticotroph tumors confirms impaired POMC processing and provides new insights into their invasive behavior.
    Zhang D, Hugo W, Bergsneider M, Wang MB, Kim W, Vinters HV, Heaney AP., Free PMC Article

    06/11/2022
    Beta-endorphin-immunoreactive perikarya appear to receive innervation from NPY-immunoreactive fiber varicosities in the human hypothalamus.

    Β-endorphin-immunoreactive perikarya appear to receive innervation from NPY-immunoreactive fiber varicosities in the human hypothalamus.
    Dudas B, Merchenthaler I.

    03/26/2022
    Pituitary-adrenal axis hormones in early-onset versus late-onset panic disorder.

    Pituitary-adrenal axis hormones in early-onset versus late-onset panic disorder.
    Masdrakis VG, Legaki EM, Papageorgiou C, Markianos M.

    03/26/2022
    Increased serum brain-derived neurotrophic factor and adrenocorticotropic hormone levels are associated with obsessive compulsive disorder in medicationfree children.

    Increased serum brain-derived neurotrophic factor and adrenocorticotropic hormone levels are associated with obsessive compulsive disorder in medication‑free children.
    Bilgiç A, Sertdemir M, Kılınç İ, Akça ÖF.

    02/19/2022
    O-GlcNAcylation Is Essential for Rapid Pomc Expression and Cell Proliferation in Corticotropic Tumor Cells.

    O-GlcNAcylation Is Essential for Rapid Pomc Expression and Cell Proliferation in Corticotropic Tumor Cells.
    Massman LJ, Pereckas M, Zwagerman NT, Olivier-Van Stichelen S., Free PMC Article

    01/15/2022
    Two Distinctive POMC Promoters Modify Gene Expression in Cushing Disease.

    Two Distinctive POMC Promoters Modify Gene Expression in Cushing Disease.
    Araki T, Tone Y, Yamamoto M, Kameda H, Ben-Shlomo A, Yamada S, Takeshita A, Yamamoto M, Kawakami Y, Tone M, Melmed S., Free PMC Article

    11/6/2021
    Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro.

    Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro.
    Carney BC, Travis TE, Moffatt LT, Johnson LS, McLawhorn MM, Simbulan-Rosenthal CM, Rosenthal DS, Shupp JW., Free PMC Article

    10/16/2021
    Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with alpha-melanocyte-stimulating hormone.

    Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte-stimulating hormone.
    Kleiner S, Rüdrich U, Gehring M, Loser K, Eiz-Vesper B, Noubissi Nzeteu GA, Patsinakidis N, Meyer NH, Gibbs BF, Raap U.

    09/25/2021
    Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients.

    Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients.
    da Fonseca ACP, Abreu GM, Zembrzuski VM, Campos Junior M, Carneiro JRI, Nogueira Neto JF, Magno FCCM, Rosado EL, Bozza PT, de Cabello GMK, Cabello PH.

    06/26/2021
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