| Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression. | Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression.
Chen S, Huang M, Hu X., Free PMC Article | 12/4/2021 |
| this paper shows that GNG2 gene polymorphism is associated with IgA nephropathy risk in Chinese Han population | 3'UTR variants of TNS3, PHLDB1, NTN4, and GNG2 genes are associated with IgA nephropathy risk in Chinese Han population.
Feng Y, Su Y, Ma C, Jing Z, Yang X, Zhang D, Xie M, Li W, Wei J. | 01/18/2020 |
| Low GNG2 expression is associated with Abdominal Aortic Aneurysm. | miR-30a-GNG2 and miR-15b-ACSS2 Interaction Pairs May Be Potentially Crucial for Development of Abdominal Aortic Aneurysm by Influencing Inflammation.
Gan S, Pan Y, Mao J. | 12/28/2019 |
| High GNG2 expression is associated with alcoholic hepatitis. | The role of the IL-8 signaling pathway in the infiltration of granulocytes into the livers of patients with alcoholic hepatitis.
French SW, Mendoza AS, Afifiyan N, Tillman B, Vitocruz E, French BA. | 11/26/2017 |
| G-protein betagamma subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. | G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
Stott JB, Povstyan OV, Carr G, Barrese V, Greenwood IA., Free PMC Article | 04/30/2016 |
| Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope. | Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Huang YJ, Zhou ZW, Xu M, Ma QW, Yan JB, Wang JY, Zhang QQ, Huang M, Bao L. | 12/5/2015 |
| Data indicate that endogenous mTOR interacts with Gbetagamma. | Gβγ interacts with mTOR and promotes its activation.
Robles-Molina E, Dionisio-Vicuña M, Guzmán-Hernández ML, Reyes-Cruz G, Vázquez-Prado J. | 05/3/2014 |
| increased protein expression level of GNG2 alone inhibits proliferation of malignant melanoma cells in vitro and in vivo | Functional analysis of GNG2 in human malignant melanoma cells.
Yajima I, Kumasaka MY, Tamura H, Ohgami N, Kato M. | 05/4/2013 |
| presence of Gng2 and Netrin-G2 immunoreactive elements in the insular cortex, but not in the putamen, suggests a possible common ontogeny of the claustrum and insula | Topography of Gng2- and NetrinG2-expression suggests an insular origin of the human claustrum.
Pirone A, Cozzi B, Edelstein L, Peruffo A, Lenzi C, Quilici F, Antonini R, Castagna M., Free PMC Article | 02/16/2013 |
| Gbetagamma inhibits Epac-induced Ca 2+ elevation in melanoma cells. Cross talk of Ca 2+ signaling between Gbetagamma & Epac plays a major role in melanoma cell migration. | Gβγ subunits inhibit Epac-induced melanoma cell migration.
Baljinnyam E, Umemura M, De Lorenzo MS, Xie LH, Nowycky M, Iwatsubo M, Chen S, Goydos JS, Iwatsubo K., Free PMC Article | 11/5/2011 |
| Data implicate the domain I-II linker region as an important contributor to voltage dependent Gbeta1/Ggamma2 modulation of Cav2.2 calcium channels. | Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition.
Tedford HW, Kisilevsky AE, Vieira LB, Varela D, Chen L, Zamponi GW., Free PMC Article | 03/5/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Data show that activation of PLCbeta(2) by alpha(q) and beta1gamma2 differ from activation by Rac2 and from each other. | Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2.
Gutman O, Walliser C, Piechulek T, Gierschik P, Henis YI., Free PMC Article | 04/12/2010 |
| signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018. | Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.
Ueda H, Nagae R, Kozawa M, Morishita R, Kimura S, Nagase T, Ohara O, Yoshida S, Asano T. | 01/21/2010 |
| Data show that G protein inhibition of N-type calcium channels is critically dependent on two separate but adjacent approximately 20-amino acid regions of the Gbeta subunit, as examined with Gbetas 1 and 5 and Ggamma2. | A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels.
Doering CJ, Kisilevsky AE, Feng ZP, Arnot MI, Peloquin J, Hamid J, Barr W, Nirdosh A, Simms B, Winkfein RJ, Zamponi GW. | 01/21/2010 |
| 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h | Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.
Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G, Hyde JD, Witten ML. | 01/21/2010 |
| Fission of transport carriers at the trans-Golgi network is dependent on specifically PLCbeta3, which is necessary to activate PKCeta and PKD in that Golgi compartment, via diacylglycerol production. | Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport.
Díaz Añel AM., Free PMC Article | 01/21/2010 |