| The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection. | The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection.
Del Rio ML, Nguyen TH, Tesson L, Heslan JM, Gutierrez-Adan A, Fernandez-Gonzalez R, Gutierrez-Arroyo J, Buhler L, Pérez-Simón JA, Anegon I, Rodriguez-Barbosa JI. | 01/8/2022 |
| CD160 Plays a Protective Role During Chronic Infection by Enhancing Both Functionalities and Proliferative Capacity of CD8+ T Cells. | CD160 Plays a Protective Role During Chronic Infection by Enhancing Both Functionalities and Proliferative Capacity of CD8+ T Cells.
Zhang L, Zhang A, Xu J, Qiu C, Zhu L, Qiu C, Fu W, Wang Y, Ye L, Fu YX, Zhao C, Zhang X, Xu J., Free PMC Article | 05/1/2021 |
| Data suggest that CD160 antigen (CD160) as a co-inhibitory receptor that delivers antigen-dependent signals in natural killer T (NKT) cells to dampen cytokine production during early innate immune activation. | CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Kim TJ, Park G, Kim J, Lim SA, Kim J, Im K, Shin MH, Fu YX, Del Rio ML, Rodriguez-Barbosa JI, Yee C, Suh KS, Kim SJ, Ha SJ, Lee KM., Free PMC Article | 12/21/2019 |
| The HVEM ligand CD160 counterbalances stimulatory signals in highly activated and cytotoxic CD8(+) T effector cells. | HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage.
Muscate F, Stetter N, Schramm C, Schulze Zur Wiesch J, Bosurgi L, Jacobs T., Free PMC Article | 10/5/2019 |
| Findings demonstrate that CD160 provides costimulatory signals to CD8(+) T cells needed for optimal CD8(+) T cell responses and protective immunity during an acute mucosal bacterial infection. | CD160 Stimulates CD8(+) T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes.
Tan CL, Peluso MJ, Drijvers JM, Mera CM, Grande SM, Brown KE, Godec J, Freeman GJ, Sharpe AH., Free PMC Article | 09/28/2019 |
| CD160 may represent a suitable target for immune intervention in the setting of transplantation to modulate allogeneic cytotoxic responses. | Modulation of cytotoxic responses by targeting CD160 prolongs skin graft survival across major histocompatibility class I barrier.
Del Rio ML, Bravo Moral AM, Fernandez-Renedo C, Buhler L, Perez-Simon JA, Chaloin O, Alvarez Nogal R, Fernandez-Caso M, Rodriguez-Barbosa JI. | 07/1/2017 |
| CD160 functionally controls cytokine production by natural killer cells. | CD160 is essential for NK-mediated IFN-γ production.
Tu TC, Brown NK, Kim TJ, Wroblewska J, Yang X, Guo X, Lee SH, Kumar V, Lee KM, Fu YX., Free PMC Article | 06/27/2015 |
| Report additive effects of IL-22 and CD160 in mediating the pro-inflammatory and pro-survival aspects of the host mucosal response in Clostridium difficile infection. | Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice.
Sadighi Akha AA, McDermott AJ, Theriot CM, Carlson PE Jr, Frank CR, McDonald RA, Falkowski NR, Bergin IL, Young VB, Huffnagle GB., Free PMC Article | 05/9/2015 |
| During chronic infection the number of CD4(+) T cells expressing programmed death-1 and CD160 were greater over the time-course study than the other CD4(+) T-cell inhibitory ligands. | CD4(+) T-cell inhibitory ligands: a tool for characterizing dysfunctional CD4(+) T cells during chronic infection.
Dow C, Henderson R, Sette A, Mothé BR., Free PMC Article | 11/16/2013 |
| CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection. | CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival.
D'Addio F, Ueno T, Clarkson M, Zhu B, Vergani A, Freeman GJ, Sayegh MH, Ansari MJ, Fiorina P, Habicht A., Free PMC Article | 11/16/2013 |
| soluble CD160, produced by mast cells, may have a role in T-cell-mast cell interactions in vivo | Human and mouse mast cells express and secrete the GPI-anchored isoform of CD160.
Ortonne N, Ram-Wolff C, Giustiniani J, Marie-Cardine A, Bagot M, Mecheri S, Bensussan A. | 06/4/2011 |
| Knockout Mice BALB C Mice C3H Mice F344 Rats K562 Cells Cultured Cells | Murine CD160, Ig-like receptor on NK cells and NKT cells, recognizes classical and nonclassical MHC class I and regulates NK cell activation.
Maeda M, Carpenito C, Russell RC, Dasanjh J, Veinotte LL, Ohta H, Yamamura T, Tan R, Takei F. | 01/21/2010 |
| CD160 is expressed on the majority of CD8(+) memory T cells as well as recently activated CD8(+) T cells | Characterization of murine CD160+ CD8+ T lymphocytes.
Tsujimura K, Obata Y, Matsudaira Y, Nishida K, Akatsuka Y, Ito Y, Demachi-Okamura A, Kuzushima K, Takahashi T. | 01/21/2010 |