| Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression. | Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression.
Ma T, Jin L, Bai S, Liu Z, Wang S, Shen B, Cho Y, Cao S, Sun MJS, Fazli L, Zhang D, Wedderburn C, Zhang DY, Mugon G, Ungerleider N, Baddoo M, Zhang K, Schiavone LH, Burkhardt BR, Fan J, You Z, Flemington EK, Dong X, Dong Y., | 03/8/2024 |
| Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts. | Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts.
Zhao H, He Q, Wu X, Liang X, Jiao Y, Zhang Y, Bao S, Xu L, Hou Y, Zhu X, Ding Y. | 05/28/2023 |
| Upregulation of FAM3B Promotes Cisplatin Resistance in Gastric Cancer by Inducing Epithelial-Mesenchymal Transition. | Upregulation of FAM3B Promotes Cisplatin Resistance in Gastric Cancer by Inducing Epithelial-Mesenchymal Transition.
Song C, Duan C., Free PMC Article | 02/20/2021 |
| Increased pancreatic-derived factor (PANDER) levels in gestational diabetes mellitus. | Increased pancreatic-derived factor (PANDER) levels in gestational diabetes mellitus.
Koroglu N, Temel Yuksel I, Aslan Cetin B, Nur Tola E, Fitnat Topbas N, Turhan U, Yetkin Yildirim G. | 08/15/2020 |
| High FAM3B promotes progression of esophageal carcinoma via regulating the AKT-MDM2-p53 signalling axis and the epithelial-mesenchymal transition. | FAM3B promotes progression of oesophageal carcinoma via regulating the AKT-MDM2-p53 signalling axis and the epithelial-mesenchymal transition.
He SL, Wang WP, Yang YS, Li EM, Xu LY, Chen LQ., Free PMC Article | 07/4/2020 |
| Taken together, by activating pro-survival mechanisms FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice, highlighting a putative role for this cytokine in prostate cancer progression. | FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-X(L) cell survival genes.
Maciel-Silva P, Caldeira I, de Assis Santos I, Carreira ACO, Siqueira FR, Antonioli E, Goldberg AC, Belizário JE, Garay-Malpartida HM, Maciel-Silva P, Caldeira I, de Assis Santos I, Carreira ACO, Siqueira FR, Antonioli E, Goldberg AC, Belizário JE, Garay-Malpartida HM., Free PMC Articles: PMC5778767, PMC5778767 | 08/18/2018 |
| FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice. | FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-X(L) cell survival genes.
Maciel-Silva P, Caldeira I, de Assis Santos I, Carreira ACO, Siqueira FR, Antonioli E, Goldberg AC, Belizário JE, Garay-Malpartida HM, Maciel-Silva P, Caldeira I, de Assis Santos I, Carreira ACO, Siqueira FR, Antonioli E, Goldberg AC, Belizário JE, Garay-Malpartida HM., Free PMC Articles: PMC5778767, PMC5778767 | 04/30/2018 |
| Data suggest that serum PANDER levels are significantly elevated in patients with long-standing type 2 diabetes as compared to patients with recently diagnosed type 2 diabetes and control subjects; serum PANDER levels vary according to degree of insulin resistance. | Association of serum pancreatic derived factor (PANDER) with beta-cell dysfunction in type 2 diabetes mellitus.
Shehata MM, Kamal MM, El-Hefnawy MH, El-Mesallamy HO. | 03/24/2018 |
| Circulating level of pancreatic-derived factor (PANDER) in relation to the accumulation in metabolic syndrome suggested that persons with elevated levels of PANDER were associated with an increased risk of metabolic syndrome. | Elevated circulating level of a cytokine, pancreatic-derived factor, is associated with metabolic syndrome components in a Chinese population.
Cao X, Yang C, Lai F, Hong Z, Lin H, Liu J, Li Y., Free PMC Article | 02/18/2017 |
| in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP. | Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter.
Ratliff WA, Athanason MG, Chechele AC, Kuehl MN, Fernandez AM, MarElia CB, Burkhardt BR. | 04/9/2016 |
| beta-cell-secreted PANDER regulated the hepatic insulin and lipogenenic signaling and impact overall glycemia. | PANDER transgenic mice display fasting hyperglycemia and hepatic insulin resistance.
Robert-Cooperman CE, Dougan GC, Moak SL, Athanason MG, Kuehl MN, Bell-Temin H, Stevens SM Jr, Burkhardt BR. | 04/5/2014 |
| It is an important regulator of glucose and lipid metabolism and plays a role in the pathogenesis of nonalcoholic fatty liver disease.(review) | Family with sequence similarity 3 gene family and nonalcoholic fatty liver disease.
Yang J, Guan Y. | 03/29/2014 |
| our studies demonstrated that silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death. | Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway.
Mou H, Li Z, Yao P, Zhuo S, Luan W, Deng B, Qian L, Yang M, Mei H, Le Y. | 09/14/2013 |
| These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug. | A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.
Li Z, Mou H, Wang T, Xue J, Deng B, Qian L, Zhou Y, Gong W, Wang JM, Wu G, Zhou CF, Fang J, Le Y., Free PMC Article | 02/2/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| PANDER is secreted from 2 types of pancreatic cells, glucose stimulates its secretion in beta cell and primary islets but not in alpha-cells, it is likely cosecreted with insulin, and structure and conformation is vital for PANDER secretion. | Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells.
Yang J, Robert CE, Burkhardt BR, Young RA, Wu J, Gao Z, Wolf BA. | 01/21/2010 |
| Localized to the islets of Langerhans. | Cloning, expression, and initial characterization of a novel cytokine-like gene family.
Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR. | 01/21/2010 |
| Helices B and C and the second disulfide bond of PANDER are essential for PANDER-induced beta-cell death. | Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells.
Yang J, Gao Z, Robert CE, Burkhardt BR, Gaweska H, Wagner A, Wu J, Greene SR, Young RA, Wolf BA. | 01/21/2010 |