| Functional modulation of lysophosphatidic acid type 2 G-protein coupled receptor facilitates alveolar bone formation. | Functional modulation of lysophosphatidic acid type 2 G-protein coupled receptor facilitates alveolar bone formation.
Kim TY, Kim A, Aryal YP, Sung S, Pokharel E, Neupane S, Choi SY, Ha JH, Jung JK, Yamamoto H, An CH, Suh JY, Sohn WJ, Lee Y, Jang IH, Norman DD, Tigyi GJ, An SY, Kim JY. | 02/5/2024 |
| LPA2 promotes neuronal differentiation and neurite formation in neocortical development. | LPA(2) promotes neuronal differentiation and neurite formation in neocortical development.
Uenaka M, Uyeda A, Nakahara T, Muramatsu R. | 03/19/2022 |
| Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells. | Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.
McDonald WS, Miyamoto K, Rivera R, Kennedy G, Almeida BSV, Kingsbury MA, Chun J., Free PMC Article | 09/4/2021 |
| Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages. | Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
Chiang JC, Chen WM, Lin KH, Hsia K, Ho YH, Lin YC, Shen TL, Lu JH, Chen SK, Yao CL, Chen BPC, Lee H., Free PMC Article | 04/17/2021 |
| Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion. | Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
Geng H, Lan R, Liu Y, Chen W, Wu M, Saikumar P, Weinberg JM, Venkatachalam MA., Free PMC Article | 03/28/2021 |
| LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon. | LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.
Shukla PK, Meena AS, Gangwar R, Szabo E, Balogh A, Chin Lee S, Vandewalle A, Tigyi G, Rao R., Free PMC Article | 03/27/2021 |
| Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2. | Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2.
Fischer C, Endle H, Schumann L, Wilken-Schmitz A, Kaiser J, Gerber S, Vogelaar CF, Schmidt MHH, Nitsch R, Snodgrass I, Thomas D, Vogt J, Tegeder I., Free PMC Article | 03/6/2021 |
| Pharmacologic activation of LPA2 attenuates Th2-driven allergic airway inflammation in a mouse model of asthma. | Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation.
Knowlden SA, Hillman SE, Chapman TJ, Patil R, Miller DD, Tigyi G, Georas SN., Free PMC Article | 07/16/2016 |
| These findings identify ATX and LPA2 as radiation-regulated genes that appear to play a physiological role in DNA repair. | The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair.
Balogh A, Shimizu Y, Lee SC, Norman DD, Gangwar R, Bavaria M, Moon C, Shukla P, Rao R, Ray R, Naren AP, Banerjee S, Miller DD, Balazs L, Pelus L, Tigyi G., Free PMC Article | 04/2/2016 |
| Lysophosphatidic acid gradients induce a spatiotemporally restricted decrease in the mobility of LPA receptor 2 (LPA2) on chemotactic fibroblasts. | Asymmetrical macromolecular complex formation of lysophosphatidic acid receptor 2 (LPA2) mediates gradient sensing in fibroblasts.
Ren A, Moon C, Zhang W, Sinha C, Yarlagadda S, Arora K, Wang X, Yue J, Parthasarathi K, Heil-Chapdelaine R, Tigyi G, Naren AP., Free PMC Article | 04/18/2015 |
| Lysophosphatidic acid signals through LPA2 receptors and Galphaq proteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and alphavbeta6 integrin-dependent manner. | Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
Geng H, Lan R, Singha PK, Gilchrist A, Weinreb PH, Violette SM, Weinberg JM, Saikumar P, Venkatachalam MA., Free PMC Article | 02/9/2013 |
| these findings identify LPA acting via lpa2 as a novel negative regulatory pathway that inhibits DC activation and allergic airway inflammation. | Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.
Emo J, Meednu N, Chapman TJ, Rezaee F, Balys M, Randall T, Rangasamy T, Georas SN., Free PMC Article | 06/23/2012 |
| LPA(1-3) are differentially expressed in the central nervous system and their expression is upregulated in response to injury. | LPA receptor expression in the central nervous system in health and following injury.
Goldshmit Y, Munro K, Leong SY, Pébay A, Turnley AM. | 10/4/2010 |
| Report role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma. | Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma.
Zhao Y, Tong J, He D, Pendyala S, Evgeny B, Chun J, Sperling AI, Natarajan V., Free PMC Article | 01/21/2010 |
| In addition to G protein-activated signals, the cooperation embedded in the LPA(2)-TRIP6-NHERF2 ternary complex provides a novel ligand-dependent signal amplification mechanism that is required for LPA(2)-mediated activation of antiapoptotic signaling. | Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect.
E S, Lai YJ, Tsukahara R, Chen CS, Fujiwara Y, Yue J, Yu JH, Guo H, Kihara A, Tigyi G, Lin FT., Free PMC Article | 01/21/2010 |
| a direct role for LPA receptor signaling in cell transformation and tumorigenesis in conjunction with c-Myc | In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.
Taghavi P, Verhoeven E, Jacobs JJ, Lambooij JP, Stortelers C, Tanger E, Moolenaar WH, van Lohuizen M. | 01/21/2010 |
| Enhanced expression of LPA2 Receptor induce a bypass of p19ARF-p53-dependent senescence. | Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.
Kortlever RM, Brummelkamp TR, van Meeteren LA, Moolenaar WH, Bernards R. | 01/21/2010 |
| A novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis. | Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling.
Ye X, Skinner MK, Kennedy G, Chun J., Free PMC Article | 01/21/2010 |
| lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival | The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival.
Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC., Free PMC Article | 01/21/2010 |
| LPA (lysophosphatidic acid) receptors couple to Gq in VSMC (vascular smooth muscle cells)and mediate migration and proliferation which may be mediated through activation of ERK1/2 and Akt. | Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq.
Kim J, Keys JR, Eckhart AD. | 01/21/2010 |