| Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile. | Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile.
Filippopoulou C, Thomé CC, Perdikari S, Ntini E, Simos G, Bohnsack KE, Chachami G., Free PMC Article | 01/30/2024 |
| EXOSC10 is a novel hepatocellular carcinoma prognostic biomarker: a comprehensive bioinformatics analysis and experiment verification. | EXOSC10 is a novel hepatocellular carcinoma prognostic biomarker: a comprehensive bioinformatics analysis and experiment verification.
Meng ZY, Fan YC, Zhang CS, Zhang LL, Wu T, Nong MY, Wang T, Chen C, Jiang LH., Free PMC Article | 09/15/2023 |
| The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing. | The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.
Chen Y, Li Y, Dai RS, Savage JC, Shinde U, Klimek J, David LL, Young EA, Hafner M, Sears RC, Sun XX, Dai MS., Free PMC Article | 05/11/2023 |
| MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus. | MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus.
Fujiwara N, Shigemoto M, Hirayama M, Fujita KI, Seno S, Matsuda H, Nagahama M, Masuda S., Free PMC Article | 09/3/2022 |
| The clinical phenotype of systemic sclerosis patients with anti-PM/Scl antibodies: results from the EUSTAR cohort. | The clinical phenotype of systemic sclerosis patients with anti-PM/Scl antibodies: results from the EUSTAR cohort.
Lazzaroni MG, Marasco E, Campochiaro C, DeVries-Bouwstra J, Gonzalez-Perez MI, Rojas-Serrano J, Hachulla E, Zanatta E, Barsotti S, Furini F, Triantafyllias K, Abignano G, Truchetet ME, De Luca G, De Langhe E, Hesselstrand R, Ingegnoli F, Bertoldo E, Smith V, Bellando-Randone S, Poormoghim H, Colombo E, Ceribelli A, Furloni A, Zingarelli S, Cavazzana I, Franceschini F, Del Galdo F, Denton CP, Cavagna L, Distler O, Allanore Y, Airò P, EUSTAR co-authors. | 01/1/2022 |
| RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis. | RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis.
Mehta C, Fraga de Andrade I, Matson DR, Dewey CN, Bresnick EH., Free PMC Article | 11/13/2021 |
| Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation. | Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.
Sun X, Kawata K, Miki A, Wada Y, Nagahama M, Takaya A, Akimitsu N. | 07/10/2021 |
| Authors engineered cells in which the 3'-->5' exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess their immediate roles in nuclear RNA biology. These transcripts are unaffected by the rapid loss of EXOSC10, suggesting that they are rarely targeted to it. | Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control.
Davidson L, Francis L, Cordiner RA, Eaton JD, Estell C, Macias S, Cáceres JF, West S., Free PMC Article | 06/6/2020 |
| Study shows that the catalytic activity of the exosome subunit EXOSC10 contributes to the homologous recombination (HR) pathway by degrading damage-induced lncRNAs and maintaining RNA homeostasis at double-strand breaks (DSBs). Results identify RNA clearance at DSBs as a step in the HR pathway that is required for the assembly of RPA onto the resected ssDNA, which in turn is a prerequisite for controlled DNA resection. | EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks.
Domingo-Prim J, Endara-Coll M, Bonath F, Jimeno S, Prados-Carvajal R, Friedländer MR, Huertas P, Visa N., Free PMC Article | 06/15/2019 |
| Processing of 3' telomerase RNA occurs in two steps with longer forms first being trimmed by RRP6 and shorter forms then being processed by PARN. | The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN.
Tseng CK, Wang HF, Schroeder MR, Baumann P., Free PMC Article | 02/23/2019 |
| Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination | Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination.
Fox MJ, Mosley AL., Free PMC Article | 10/22/2016 |
| EXOSC10 can be modified by SUMOylation and identifies a physiological stress where this regulation is prevalent both in vitro and in vivo. | Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.
Knight JR, Bastide A, Peretti D, Roobol A, Roobol J, Mallucci GR, Smales CM, Willis AE., Free PMC Article | 08/13/2016 |
| Results show that DGCR8 forms an alternative complex with the RRP6-containing form of the exosome, acts as an adaptor to recruit the exosome to target structured RNAs, and the DGCR8/hRRP6 complex controls the stability of human telomerase RNA. | DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.
Macias S, Cordiner RA, Gautier P, Plass M, Cáceres JF., Free PMC Article | 04/30/2016 |
| Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR. | Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII.
Wagschal A, Rousset E, Basavarajaiah P, Contreras X, Harwig A, Laurent-Chabalier S, Nakamura M, Chen X, Zhang K, Meziane O, Boyer F, Parrinello H, Berkhout B, Terzian C, Benkirane M, Kiernan R., Free PMC Article | 11/24/2012 |
| Systemic sclerosis patients with anti-PM-Scl antibody are younger and significantly more often have limited cutaneous involvement, skeletal muscle disease, pulmonary fibrosis and calcinosis. | Anti-PM-Scl antibody in patients with systemic sclerosis.
Koschik RW 2nd, Fertig N, Lucas MR, Domsic RT, Medsger TA Jr. | 08/18/2012 |
| Saccharomyces cerevisiae Rrp6, and determined the X-ray structure of a human construct containing the exoribonuclease and HRDC domains that retains catalytic activity | Activities of human RRP6 and structure of the human RRP6 catalytic domain.
Januszyk K, Liu Q, Lima CD., Free PMC Article | 09/24/2011 |
| autoantibodies specific to this antigen also are found in systemic sclerosis | PM1-Alpha ELISA: the assay of choice for the detection of anti-PM/Scl autoantibodies?
Mahler M, Fritzler MJ. | 01/21/2010 |
| Anti-PM/Scl antibodies are common in distinct SSc subsets and are associated with several clinical symptoms | Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients.
Hanke K, Brückner CS, Dähnrich C, Huscher D, Komorowski L, Meyer W, Janssen A, Backhaus M, Becker M, Kill A, Egerer K, Burmester GR, Hiepe F, Schlumberger W, Riemekasten G., Free PMC Article | 01/21/2010 |
| Although not required for exosome stability, PM/Scl-100 and PM/Scl-75 are involved in mRNA degradation. | Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.
van Dijk EL, Schilders G, Pruijn GJ., Free PMC Article | 01/21/2010 |
| cloning of a more complete cDNA for PM/Scl-75 encoded 84 additional amino acids at its N terminus and only this longer polypeptide is able to associate with the exosome complex. | The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ. | 01/21/2010 |
| PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. | PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome.
Raijmakers R, Renz M, Wiemann C, Egberts WV, Seelig HP, van Venrooij WJ, Pruijn GJ. | 03/21/2004 |
| Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. | Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ. | 03/19/2004 |