| Celsr2 regulates NMDA receptors and dendritic homeostasis in dorsal CA1 to enable social memory. | Celsr2 regulates NMDA receptors and dendritic homeostasis in dorsal CA1 to enable social memory.
Chen B, Wang L, Li X, Shi Z, Duan J, Wei JA, Li C, Pang C, Wang D, Zhang K, Chen H, Na W, Zhang L, So KF, Zhou L, Jiang B, Yuan TF, Qu Y. | 10/11/2024 |
| Celsr2-mediated morphological polarization and functional phenotype of reactive astrocytes in neural repair. | Celsr2-mediated morphological polarization and functional phenotype of reactive astrocytes in neural repair.
Liu A, Yu L, Li X, Zhang K, Zhang W, So KF, Tissir F, Qu Y, Zhou L. | 06/13/2023 |
| Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses. | Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses.
Li C, Wei JA, Wang D, Luo Z, Pang C, Chen K, Duan J, Chen B, Zhou L, Tissir F, Shi L, So KF, Zhang L, Qu Y. | 12/10/2022 |
| Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. | Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human.
Wen Q, Weng H, Liu T, Yu L, Zhao T, Qin J, Li S, Wu Q, Tissir F, Qu Y, Zhou L., Free PMC Article | 04/23/2022 |
| CELSR2 deficiency suppresses lipid accumulation in hepatocyte by impairing the UPR and elevating ROS level. | CELSR2 deficiency suppresses lipid accumulation in hepatocyte by impairing the UPR and elevating ROS level.
Tan J, Che Y, Liu Y, Hu J, Wang W, Hu L, Zhou Q, Wang H, Li J. | 10/30/2021 |
| The first signal, controlled by cadherin, EGF-like, laminin G-like, seven-pass, G-type receptor (Celsr) 2, Celsr3, Frizzled3 (Fzd3) and Van Gogh like2 (Vangl2) organizes multicilia in individual cells (single-cell polarity) | A dual role for planar cell polarity genes in ciliated cells.
Boutin C, Labedan P, Dimidschstein J, Richard F, Cremer H, André P, Yang Y, Montcouquiol M, Goffinet AM, Tissir F., Free PMC Article | 11/8/2014 |
| Celsr2-3 and Fzd3 regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1-2 that remain to be identified. | Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.
Qu Y, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L, Goffinet AM., Free PMC Article | 10/4/2014 |
| Study shows Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain quiescent long-term hematopoietic stem cells. | Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche.
Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L., Free PMC Article | 10/6/2012 |
| Celsr2 and Celsr3 control the development and function of ependymal cilia; findings suggest that planar cell polarity signaling is involved in ependymal cilia development and in the pathophysiology of hydrocephalus, and possibly other ciliopathies | Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.
Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM. | 06/28/2010 |
| Developmental expression profiles of Celsr (Flamingo) genes in the mouse | Developmental expression profiles of Celsr (Flamingo) genes in the mouse.
Tissir F, De-Backer O, Goffinet AM, Lambert de Rouvroit C. | 01/21/2010 |
| Upregulation of Flamingo1/Celsr2 gene expression in both early and chronic phases of enlargement in the granule cells of the hypertrophic dentate gyrus may correlate mouse Flamingo1/Celsr2 to the development of hippocampal sclerosis. | Mouse Flamingo1/Celsr2 relates neuronal reorganization of the hypertrophic dentate granule cells after kainate injection.
Hirai H, Suzuki F, Kurokawa K, Mitsuya K, Matsuda M. | 01/21/2010 |
| Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development | Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development.
Shima Y, Copeland NG, Gilbert DJ, Jenkins NA, Chisaka O, Takeichi M, Uemura T. | 01/21/2010 |