| High expression of NF-kappaB inducing kinase in the bulge region of hair follicle induces tumor. | High expression of NF-κB inducing kinase in the bulge region of hair follicle induces tumor.
Duan W, Guo S, Huang HP, Tian Y, Li Z, Bi Y, Yi L, Cao M, Guo M, Li Y, Liu Y, Li C. | 08/30/2023 |
| EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia. | EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
Bilgic SN, Domaniku A, Toledo B, Agca S, Weber BZC, Arabaci DH, Ozornek Z, Lause P, Thissen JP, Loumaye A, Kir S. | 06/1/2023 |
| NF-kappaB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis. | NF-κB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis.
Pflug KM, Lee DW, Keeney JN, Sitcheran R. | 05/23/2023 |
| NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. | NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, Georgomanolis T, Altmüller J, Pasparakis M, Schmidt A, Krüger M, Supprian MS, Waisman A, Straub BK, Raschzok N, Bernier M, Birkenfeld AL, Hövelmeyer N, Brüning JC, Wunderlich FT., Free PMC Article | 12/24/2022 |
| Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-kappaB-inducing kinase in mice. | Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice.
Xu C, Zhou H, Jin Y, Sahay K, Robicsek A, Liu Y, Dong K, Zhou J, Barrett A, Su H, Chen W., Free PMC Article | 12/24/2022 |
| Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice. | Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
Zhang Z, Zhong X, Shen H, Sheng L, Liangpunsakul S, Lok AS, Omary MB, Wang S, Rui L., Free PMC Article | 09/17/2022 |
| Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development. | Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of T(reg) development.
Haftmann C, Zwicky P, Ingelfinger F, Mair F, Floess S, Riedel R, Durek P, Spalinger MR, Friebel E, Leung BP, Lutz M, Puertas N, Amorim A, Schärli S, Becher B, Kisielow J, Waisman A, Mashreghi MF, Huehn J, Becher B. | 03/12/2022 |
| Constitutive activation of NF-kappaB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma. | Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
Davis JL, Thaler R, Cox L, Ricci B, Zannit HM, Wan F, Faccio R, Dudakovic A, van Wijnen AJ, Veis DJ., Free PMC Article | 11/13/2021 |
| NF-kappaB-inducing kinase maintains T cell metabolic fitness in antitumor immunity. | NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Gu M, Zhou X, Sohn JH, Zhu L, Jie Z, Yang JY, Zheng X, Xie X, Yang J, Shi Y, Brightbill HD, Kim JB, Wang J, Cheng X, Sun SC., Free PMC Article | 04/13/2021 |
| NIK links inflammation to hepatic steatosis by suppressing PPARalpha in alcoholic liver disease. | NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease.
Li Y, Chen M, Zhou Y, Tang C, Zhang W, Zhong Y, Chen Y, Zhou H, Sheng L., Free PMC Article | 04/13/2021 |
| Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia. | Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia.
Lu YJ, Jan YJ, Ko BS, Liang SM, Chen L, Wu CC, Chin CH, Kuo CC, Yet SF, Liou JY., Free PMC Article | 02/27/2021 |
| NF-kappaB-inducing kinase contributes to normal development of cortical thymic epithelial cells: its possible role in shaping a proper T-cell repertoire. | NF-κB-inducing kinase contributes to normal development of cortical thymic epithelial cells: its possible role in shaping a proper T-cell repertoire.
Eshima K, Misawa K, Ohashi C, Noma H, Iwabuchi K., Free PMC Article | 11/21/2020 |
| SMAC mimetics promote NIK-dependent inhibition of CD4(+) TH17 cell differentiation. | SMAC mimetics promote NIK-dependent inhibition of CD4(+) T(H)17 cell differentiation.
Rizk J, Kaplinsky J, Agerholm R, Kadekar D, Ivars F, Agace WW, Wong WW, Szucs MJ, Myers SA, Carr SA, Waisman A, Bekiaris V. | 08/15/2020 |
| NIK is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling. | NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.
Lacher SM, Thurm C, Distler U, Mohebiany AN, Israel N, Kitic M, Ebering A, Tang Y, Klein M, Wabnitz GH, Wanke F, Samstag Y, Bopp T, Kurschus FC, Simeoni L, Tenzer S, Waisman A. | 10/5/2019 |
| Islet alpha-cell specific overexpression of NIK results in islet alpha-cell dysfunction and causes islet beta-cell death and pancreatitis, which are most likely due to paracrine secretion of cytokines and chemokines from islet alpha cells, thus leading to hypoglycemia, growth retardation, and postnatal death in mice. | Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.
Li X, Jia L, Chen X, Dong Y, Ren X, Dong Y, Chen Y, Xie L, Liu M, Shiota C, Gittes GK, Rui L, Chen Z., Free PMC Article | 09/7/2019 |
| our data suggest a pivotal role for the NIK signaling axis in regulating dendritic cell functions in intestinal immunity and homeostasis. | NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis.
Jie Z, Yang JY, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, Cheng X, Sun SC., Free PMC Article | 04/27/2019 |
| A TRAF3-NIK axis differentially regulates viral DNA vs RNA pathways in innate immune signaling. | A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling.
Parvatiyar K, Pindado J, Dev A, Aliyari SR, Zaver SA, Gerami H, Chapon M, Ghaffari AA, Dhingra A, Cheng G., Free PMC Article | 12/22/2018 |
| Pathological activation of hepatic NIK likely blocks hepatocyte replication, contributing to liver disease progression. | Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases.
Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L., Free PMC Article | 11/24/2018 |
| Nik(-/-) mice could be useful as a spontaneous model of specific features of Eosinophilic esophagitis. | Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis.
Eden K, Rothschild DE, McDaniel DK, Heid B, Allen IC., Free PMC Article | 07/28/2018 |
| global or thymus-specific ablation of the NIK gene results in fatal autoimmune liver disease in mice. | Thymic NF-κB-inducing kinase regulates CD4(+) T cell-elicited liver injury and fibrosis in mice.
Shen H, Sheng L, Xiong Y, Kim YH, Jiang L, Chen Z, Liu Y, Pyaram K, Chang CH, Rui L., Free PMC Article | 04/7/2018 |
| These findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1. | NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion.
Jung JU, Ravi S, Lee DW, McFadden K, Kamradt ML, Toussaint LG, Sitcheran R., Free PMC Article | 01/27/2018 |
| constitutive activation of NIK in the hematopoietic system leads to bone marrow (BM) failure and postnatal lethality. | Constitutive Activation of NIK Impairs the Self-Renewal of Hematopoietic Stem/Progenitor Cells and Induces Bone Marrow Failure.
Xiu Y, Xue WY, Lambertz A, Leidinger M, Gibson-Corley K, Zhao C., Free PMC Article | 12/23/2017 |
| results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100. | The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100.
Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G. | 11/25/2017 |
| NIK pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity. | Liver NF-κB-Inducing Kinase Promotes Liver Steatosis and Glucose Counterregulation in Male Mice With Obesity.
Liu Y, Sheng L, Xiong Y, Shen H, Liu Y, Rui L., Free PMC Article | 10/14/2017 |
| this study demonstrates that although NIK is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells | Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses.
Li Y, Wang H, Zhou X, Xie X, Chen X, Jie Z, Zou Q, Hu H, Zhu L, Cheng X, Brightbill HD, Wu LC, Wang L, Sun SC., Free PMC Article | 01/14/2017 |