| Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P5 in live cells. | Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P(5) in live cells.
Hong H, Yoon B, Ghil S. | 11/22/2021 |
| our findings establish that S1PR5 is of central importance for human NK-cell response to sphingosine-1-phosphate and suggest that it is required for their egress from the bone marrow and secondary lymphoid organs. | S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate.
Drouillard A, Mathieu AL, Marçais A, Belot A, Viel S, Mingueneau M, Guckian K, Walzer T. | 08/3/2019 |
| Reduced DNA methylation may underlie the increased expression of the S1PR5 gene in alveolar macrophages and associated defective efferocytosis in COPD. | Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.
Barnawi J, Jersmann H, Haberberger R, Hodge S, Meech R. | 12/23/2017 |
| Data indicate that the mitotic kinase Polo-like kinase 1 (PLK1) was an important effector of S1P-S1P5 signaling, and a new function of the SphK1-S1P pathway specifically in the control of mitosis in HeLa cells. | Sphingosine 1-phosphate signaling through its receptor S1P(5) promotes chromosome segregation and mitotic progression.
Andrieu G, Ledoux A, Branka S, Bocquet M, Gilhodes J, Walzer T, Kasahara K, Inagaki M, Sabbadini RA, Cuvillier O, Hatzoglou A. | 12/2/2017 |
| TGF-beta2 dependent upregulation of S1P5 is required for the induction of pro-fibrotic CTGF by TGF-beta in mesangial cells. | Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.
Wünsche C, Koch A, Goldschmeding R, Schwalm S, Meyer Zu Heringdorf D, Huwiler A, Pfeilschifter J. | 08/29/2015 |
| This report is the first to demonstrate a reduction in S1P5 in multiple sclerosis lesions, which parallels that of myelin loss. | Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions.
Brana C, Frossard MJ, Pescini Gobert R, Martinier N, Boschert U, Seabrook TJ. | 02/28/2015 |
| Data show that sphingosine kinase SphK1 and sphingosine-1-phosphate (S1P) receptors S1P1, S1P2, S1P3, and S1P5 were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 levels were highest in primary tumors. | The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.
Quint K, Stiel N, Neureiter D, Schlicker HU, Nimsky C, Ocker M, Strik H, Kolodziej MA. | 01/3/2015 |
| Edg-5 receptor in brain endothelial cells contributes to optimal barrier formation and maintenance of immune quiescence of the barrier endothelium. | Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier.
van Doorn R, Lopes Pinheiro MA, Kooij G, Lakeman K, van het Hof B, van der Pol SM, Geerts D, van Horssen J, van der Valk P, van der Kam E, Ronken E, Reijerkerk A, de Vries HE., Free PMC Article | 06/15/2013 |
| The decreased expression level of S1PR5 on NK cells is associated with graft versus host disease occurrence after allogeneic hematopoietic stem cell transplantation. | [Influence of NK cell S1PR5 expression on graft versus host disease in allogeneic hematopoietic stem cell transplantation].
Guan LX, Cai B, Gao L, Li XH, Li M, Wang LL, Gao CJ. | 12/22/2012 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide study reveals copy number variants exclusive to childhood obesity cases.
Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF., Free PMC Article | 12/5/2010 |
| Results suggest that, under serum-starved conditions, sphingosine 1-phosphate (S1P) further upregulates autophagic activity through S1P(5)-dependent pathways in PC-3 cells. | S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.
Chang CL, Ho MC, Lee PH, Hsu CY, Huang WP, Lee H. | 01/21/2010 |
| The centrosomal sphingosine-1-phosphate receptor 5 might function as an intracellular target of sphingosine-1-phosphate linked to regulation of mitosis. | The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division.
Gillies L, Lee SC, Long JS, Ktistakis N, Pyne NJ, Pyne S. | 01/21/2010 |
| FTY720 induces time-dependent modulation of S1P receptors on human OPCs with consequent functional responses that are directly relevant for the remyelination process. | FTY720 modulates human oligodendrocyte progenitor process extension and survival.
Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP. | 01/21/2010 |
| differences between hS1P(5) and rS1P(5) will be an important point to be considered in the development of selective receptor antagonists. | Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists.
Niedernberg A, Scherer CR, Busch AE, Kostenis E. | 01/21/2010 |
| identify and characterize the gene; describe its expression in normal tissues and large granular lymphocyte leukemia monocytes | Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia.
Kothapalli R, Kusmartseva I, Loughran TP. | 01/21/2010 |
| The molecular identity, functional properties, and expression profile of the S1P5 (Edg-8) receptor have been characterized. | Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.
Im DS, Clemens J, Macdonald TL, Lynch KR. | 01/21/2010 |