| Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition. | Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition.
van der Spek SJF, Pandya NJ, Koopmans F, Paliukhovich I, van der Schors RC, Otten M, Smit AB, Li KW., Free PMC Article | 12/3/2022 |
| Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. | Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Yu J, Rao P, Clark S, Mitra J, Ha T, Gouaux E., Free PMC Article | 01/15/2022 |
| The central distribution of AMPARs is absent in GluA3-knockout mice, and gold particles are evenly distributed along the postsynaptic density. GluA4 gold labeling was homogenously distributed along both synapse types. Thus, GluA3 and GluA4 subunits are distributed at auditory nerve synapses in a target-cell-dependent manner. | The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells.
Rubio ME, Matsui K, Fukazawa Y, Kamasawa N, Harada H, Itakura M, Molnár E, Abe M, Sakimura K, Shigemoto R., Free PMC Article | 06/23/2018 |
| The experiments reveal a novel type of plasticity at CA1 hippocampal synapses that is expressed by the activation of GluA3-containing AMPARs. | Synaptic plasticity through activation of GluA3-containing AMPA-receptors.
Renner MC, Albers EH, Gutierrez-Castellanos N, Reinders NR, van Huijstee AN, Xiong H, Lodder TR, Kessels HW., Free PMC Article | 05/19/2018 |
| Results suggest a role for GluA3 channel activity in the regulation of sleep behavior in both mice and humans. | A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.
Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A, WGS500 Consortium, Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC., Free PMC Article | 03/10/2018 |
| GluA3 is required for normal auditory signaling, normal ultrastructure of AN-BC synapses in the cochlear nucleus and normal experience-dependent changes in auditory processing after transient sound reduction. | Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors.
García-Hernández S, Abe M, Sakimura K, Rubio ME., Free PMC Article | 03/3/2018 |
| These experiments indicate that the presence of GluA3-containing AMPARs is critical for Abeta-mediated synaptic and cognitive deficits. | Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3.
Reinders NR, Pao Y, Renner MC, da Silva-Matos CM, Lodder TR, Malinow R, Kessels HW., Free PMC Article | 02/3/2018 |
| Cerebellar learning depends on expression of GluA3 in Purkinje cells. GluA3 is required to induce long term potentiation (LTP), but not long term depression, at parallel fiber-Purkinje cell synapses. GluA3-dependent potentiation involves a cAMP-driven change in channel conductance. GluA3-mediated LTP and learning are induced via cAMP-mediated Epac activation. | Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3.
Gutierrez-Castellanos N, Da Silva-Matos CM, Zhou K, Canto CB, Renner MC, Koene LMC, Ozyildirim O, Sprengel R, Kessels HW, De Zeeuw CI., Free PMC Article | 07/29/2017 |
| These results provide direct evidence for cortical AMPA receptors to contribute to zymosan-induced visceral and spontaneous pain. | Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain.
Liu SB, Zhang MM, Cheng LF, Shi J, Lu JS, Zhuo M., Free PMC Article | 07/16/2016 |
| Data indicate that the AMPA receptor subunits abundance is hippocampus, GluA2 > GluA1 > GluA3 >> GluA4; cortex, GluA2 > GluA3 >/= GluA1 >> GluA4; and cerebellum, GluA2 > GluA3 >/= GluA1 > GluA4. | Interaction proteomics reveals brain region-specific AMPA receptor complexes.
Chen N, Pandya NJ, Koopmans F, Castelo-Székelv V, van der Schors RC, Smit AB, Li KW. | 10/31/2015 |
| This study demonistrated that Gria3 gene expression in mouse dorsal raphe nucleus | Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Templin JS, Bang SJ, Soiza-Reilly M, Berde CB, Commons KG., Free PMC Article | 09/15/2012 |
| This study demonistrated that the GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum. | GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum.
Adamczyk A, Mejias R, Takamiya K, Yocum J, Krasnova IN, Calderon J, Cadet JL, Huganir RL, Pletnikov MV, Wang T., Free PMC Article | 06/30/2012 |
| GluR2 and GluR3 subunits of AMPA receptor play roles in the trigeminal nerve injury-mediated enhancement of neuronal excitability and hyperalgesia. | Involvement of GluR2 and GluR3 subunit C-termini in the trigeminal spinal subnucleus caudalis and C1-C2 neurons in trigeminal neuropathic pain.
Miyamoto M, Tsuboi Y, Takamiya K, Huganir RL, Kondo M, Shinoda M, Oi Y, Iwata K., Free PMC Article | 12/31/2011 |
| MCT2 is linked to AMPA receptor GluR2/3 subunits and undergoes a similar translocation process in neurons upon activation | Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process.
Pierre K, Chatton JY, Parent A, Repond C, Gardoni F, Di Luca M, Pellerin L. | 01/21/2010 |
| GluR3 subunits have diverse neurophysiological impact, modulating oscillatory networks for sleep, breathing and seizure generation. | GluR3 subunit regulates sleep, breathing and seizure generation.
Steenland HW, Kim SS, Zhuo M. | 01/21/2010 |
| most important property of GluR2 in the context of AMPA receptors trafficking may be its influence on calcium permeability | Endocytosis and recycling of AMPA receptors lacking GluR2/3.
Biou V, Bhattacharyya S, Malenka RC., Free PMC Article | 01/21/2010 |
| By the use of two separate cohorts of mice and by means of two different animal models, namely the cue-induced reinstatement and alcohol deprivation effect paradigms, we could show that the GluR-C subunit is involved in alcohol seeking and relapse. | Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse.
Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, Sprengel R, Spanagel R., Free PMC Article | 01/21/2010 |
| limited proteolysis is another post-translational mechanism through which functional diversity and specialization between closely related GluR subunits is accomplished | Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase.
Meyer EL, Strutz N, Gahring LC, Rogers SW. | 01/21/2010 |
| Mice treated with anti-Glur3 antisense peptide nucleic acids had significantly extended survival compared to mice injected with a nonsense sequence in a mouse model of Amyotrophic lateral sclerosis | Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS.
Rembach A, Turner BJ, Bruce S, Cheah IK, Scott RL, Lopes EC, Zagami CJ, Beart PM, Cheung NS, Langford SJ, Cheema SS. | 01/21/2010 |