| An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice. | An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice.
Okuzono S, Fujii F, Setoyama D, Taira R, Shinmyo Y, Kato H, Masuda K, Yonemoto K, Akamine S, Matsushita Y, Motomura Y, Sakurai T, Kawasaki H, Han K, Kato TA, Torisu H, Kang D, Nakabeppu Y, Ohga S, Sakai Y., Free PMC Article | 09/13/2024 |
| Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription. | Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription.
Lu Y, Meng L, Ren R, Wang X, Sui W, Xue F, Xie L, Chen A, Zhao Y, Yang J, Zhang W, Yu X, Xi B, Xu F, Zhang M, Zhang Y, Zhang C. | 05/30/2024 |
| LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation. | LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation.
Chen S, Wang J, Zhang K, Ma B, Li X, Wei R, Nian H., Free PMC Article | 09/19/2023 |
| NONO regulates B-cell development and B-cell receptor signaling. | NONO regulates B-cell development and B-cell receptor signaling.
Zhang Y, Cui D, Huang M, Zheng Y, Zheng B, Chen L, Chen Q. | 03/16/2023 |
| NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway. | NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway.
Niu Y, Xu G, Zhu S, Wei X, Wu C, Zhang R, Chen C, Yan L, Luo H, Deng S, Wu W, Li Y, Liu M, Jiang Y, Zhang X. | 01/28/2023 |
| Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention. | Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.
Wang X, Han M, Wang S, Sun Y, Zhao W, Xue Z, Liang X, Huang B, Li G, Chen A, Li X, Wang J., Free PMC Article | 08/6/2022 |
| A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells. | A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.
Yamamoto K, Goyama S, Asada S, Fujino T, Yonezawa T, Sato N, Takeda R, Tsuchiya A, Fukuyama T, Tanaka Y, Yokoyama A, Toya H, Kon A, Nannya Y, Onoguchi-Mizutani R, Nakagawa S, Hirose T, Ogawa S, Akimitsu N, Kitamura T. | 02/12/2022 |
| Transcriptional silencing of fetal hemoglobin expression by NonO. | Transcriptional silencing of fetal hemoglobin expression by NonO.
Li X, Chen M, Liu B, Lu P, Lv X, Zhao X, Cui S, Xu P, Nakamura Y, Kurita R, Chen B, Huang DCS, Liu DP, Liu M, Zhao Q., Free PMC Article | 12/18/2021 |
| Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury. | Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury.
Xu (徐兴丽) X, Xu (徐兴华) X, Mao (毛洋) Y, Lu (卢琳) L, Ma (马静) J, Zheng (郑腾飞) T, Zhang (张杰) J, Zhang (章萌) M, Meng (孟霖霖) L, Ma (马连越) L, Cheng (程晶) J, Chen (陈文强) W, Jiang (姜虹) H, Zhang (张运) Y, Zhang (张澄) C. | 06/5/2021 |
| Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro. | Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.
Fefilova A, Melnikov P, Prikazchikova T, Abakumova T, Kurochkin I, Mazin PV, Ziganshin R, Sergeeva O, Zatsepin TS., Free PMC Article | 02/20/2021 |
| G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA. | G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA.
Simko EAJ, Liu H, Zhang T, Velasquez A, Teli S, Haeusler AR, Wang J., Free PMC Article | 09/19/2020 |
| Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells. | Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells.
Li W, Karwacki-Neisius V, Ma C, Tan L, Shi Y, Wu F, Shi YG., Free PMC Article | 09/12/2020 |
| Silencing of NONO inhibits abdominal aortic aneurysm in apolipoprotein E-knockout mice via collagen deposition and inflammatory inhibition. | Silencing of NONO inhibits abdominal aortic aneurysm in apolipoprotein E-knockout mice via collagen deposition and inflammatory inhibition.
Xu X, Zhang F, Lu Y, Yu S, Sun W, Sun S, Cheng J, Ma J, Zhang M, Zhang C, Zhang Y, Zhang K., Free PMC Article | 09/12/2020 |
| NONO deficiency was associated with developing heart defects in mice. | Deficiency of NONO is associated with impaired cardiac function and fibrosis in mice.
Xu X, Jiang H, Lu Y, Zhang M, Cheng C, Xue F, Zhang M, Zhang C, Ni M, Zhang Y. | 07/11/2020 |
| NONO Regulates Cortical Neuronal Migration and Postnatal Neuronal Maturation. | NONO Regulates Cortical Neuronal Migration and Postnatal Neuronal Maturation.
Liu X, Zheng J, Qi S, Shen Q., Free PMC Article | 05/16/2020 |
| NONO post-transcriptionally coordinates circadian mRNA expression of metabolic genes with the feeding/fasting cycle, thereby playing a critical role in energy homeostasis. | The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding.
Benegiamo G, Mure LS, Erikson G, Le HD, Moriggi E, Brown SA, Panda S., Free PMC Article | 06/8/2019 |
| Nono overexpression increased the expression of pro-inflammatory cytokines leading to increased atherosclerotic plaque formation. | Silencing of Non-POU-domain-containing octamer-binding protein stabilizes atherosclerotic plaque in apolipoprotein E-knockout mice via NF-κB signaling pathway.
Zhang K, Zhang F, Yang JM, Kong J, Meng X, Zhang M, Zhang C, Zhang Y. | 12/22/2018 |
| These findings argue that Nono collaborates with Erk signaling to regulate the integrity of bivalent domains and Mouse embryonic stem cell pluripotency. | Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency.
Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F, Shi Y., Free PMC Article | 11/26/2017 |
| NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo. | Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes.
Li S, Shu FJ, Li Z, Jaafar L, Zhao S, Dynan WS., Free PMC Article | 07/29/2017 |
| Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1)-aldehyde dehydrogenase 1 (NONO/PSPC1-ALDH1A1) in the modulation of Sertoli cells (SCs) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge. | Synergistic upregulation of NONO and PSPC1 regulates Sertoli cell response to MEHP via modulation of ALDH1A1 signaling.
Dong BW, Jin XH, Yan CY, Yang T, Cai GQ, Lu J. | 06/3/2017 |
| This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 to one of its target RNAs. | Structure, Dynamics, and Interaction of p54(nrb)/NonO RRM1 with 5' Splice Site RNA Sequence.
Duvignaud JB, Bédard M, Nagata T, Muto Y, Yokoyama S, Gagné SM, Vincent M. | 04/29/2017 |
| mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets | Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).
Desai SS, Kharade SS, Parekh VI, Iyer S, Agarwal SK., Free PMC Article | 02/20/2016 |
| Cytoplasmic granule containing HERMES, NonO, PSF, and G3BP1 is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation. | Interaction and colocalization of HERMES/RBPMS with NonO, PSF, and G3BP1 in neuronal cytoplasmic RNP granules in mouse retinal line cells.
Furukawa MT, Sakamoto H, Inoue K. | 09/26/2015 |
| Quantitative proteomics reveals dynamic interaction of JNK with RNA transport granule proteins Sfpq and Nono during neuronal differentiation | Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.
Sury MD, McShane E, Hernandez-Miranda LR, Birchmeier C, Selbach M., Free PMC Article | 09/5/2015 |
| We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis. | AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis.
Xu K, Yang L, Zhao D, Wu Y, Qi H. | 01/24/2015 |