| A gain-of-function variation in PLCG1 causes a new immune dysregulation disease. | A gain-of-function variation in PLCG1 causes a new immune dysregulation disease.
Tao P, Han X, Wang Q, Wang S, Zhang J, Liu L, Fan X, Liu C, Liu M, Guo L, Lee PY, Aksentijevich I, Zhou Q., Free PMC Article | 11/13/2023 |
| Endothelial VEGFR2-PLCgamma signaling regulates vascular permeability and antitumor immunity through eNOS/Src. | Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src.
Sjöberg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love DT, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L., Free PMC Article | 11/1/2023 |
| Expression of BCL11A in chronic lymphocytic leukaemia. | Expression of BCL11A in chronic lymphocytic leukaemia.
Tosic N, Ugrin M, Marjanovic I, Kostic T, Vukovic V, Tomic K, Otasevic V, Antic D, Mihaljevic B, Pavlovic S, Karan-Djurasevic T. | 01/21/2023 |
| A frequent PLCgamma1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells. | A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.
Prawiro C, Bunney TD, Kampyli C, Yaguchi H, Katan M, Bangham CRM. | 12/31/2022 |
| Loss of phospholipase Cgamma1 suppresses hepatocellular carcinogenesis through blockade of STAT3-mediated cancer development. | Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3-mediated cancer development.
Seo EB, Jang HJ, Kwon SH, Kwon YJ, Kim SK, Lee SH, Jeong AJ, Shin HM, Kim YN, Ma S, Kim H, Lee YH, Suh PG, Ye SK., Free PMC Article | 10/29/2022 |
| Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCgamma1 axis. | Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis.
Xu J, Zhong Y, Yin H, Linneman J, Luo Y, Xia S, Xia Q, Yang L, Huang X, Kang K, Wang J, Niu Y, Li L, Gou D., Free PMC Article | 08/27/2022 |
| PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. | PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
Schnoeder TM, Schwarzer A, Jayavelu AK, Hsu CJ, Kirkpatrick J, Döhner K, Perner F, Eifert T, Huber N, Arreba-Tutusaus P, Dolnik A, Assi SA, Nafria M, Jiang L, Dai YT, Chen Z, Chen SJ, Kellaway SG, Ptasinska A, Ng ES, Stanley EG, Elefanty AG, Buschbeck M, Bierhoff H, Brodt S, Matziolis G, Fischer KD, Hochhaus A, Chen CW, Heidenreich O, Mann M, Lane SW, Bullinger L, Ori A, von Eyss B, Bonifer C, Heidel FH., Free PMC Article | 03/5/2022 |
| Phospholipase Cgamma1 (PLCG1) overexpression is associated with tumor growth and poor survival in IDH wild-type lower-grade gliomas in adult patients. | Phospholipase Cγ1 (PLCG1) overexpression is associated with tumor growth and poor survival in IDH wild-type lower-grade gliomas in adult patients.
Li T, Yang Z, Li H, Zhu J, Wang Y, Tang Q, Shi Z., Free PMC Article | 02/19/2022 |
| A computational in silico approach to predict high-risk coding and non-coding SNPs of human PLCG1 gene. | A computational in silico approach to predict high-risk coding and non-coding SNPs of human PLCG1 gene.
Khan SM, Faisal AM, Nila TA, Binti NN, Hosen MI, Shekhar HU., Free PMC Article | 01/22/2022 |
| PLCgamma1dependent invasion and migration of cells expressing NSCLCassociated EGFR mutants. | PLCγ1‑dependent invasion and migration of cells expressing NSCLC‑associated EGFR mutants.
Mittal S, Kamath A, Joseph AM, Rajala MS. | 07/17/2021 |
| Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening. | Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
Kim SH, Yang S, Lim KH, Ko E, Jang HJ, Kang M, Suh PG, Joo JY., Free PMC Article | 05/22/2021 |
| Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells. | Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells.
Grebert C, Becq F, Vandebrouck C. | 03/28/2021 |
| FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer. | FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer.
Kim KB, Kim Y, Rivard CJ, Kim DW, Park KS., Free PMC Article | 02/13/2021 |
| Reduced PLCG1 expression is associated with inferior survival for myelodysplastic syndromes. | Reduced PLCG1 expression is associated with inferior survival for myelodysplastic syndromes.
Shiseki M, Ishii M, Miyazaki M, Osanai S, Wang YH, Yoshinaga K, Mori N, Tanaka J., Free PMC Article | 02/6/2021 |
| PLCgamma1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. | PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia.
Saliakoura M, Rossi Sebastiano M, Pozzato C, Heidel FH, Schnöder TM, Savic Prince S, Bubendorf L, Pinton P, A Schmid R, Baumgartner J, Freigang S, Berezowska SA, Rimessi A, Konstantinidou G., Free PMC Article | 02/2/2021 |
| Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes. | Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
Liu Y, Bunney TD, Khosa S, Macé K, Beckenbauer K, Askwith T, Maslen S, Stubbs C, de Oliveira TM, Sader K, Skehel M, Gavin AC, Phillips C, Katan M., Free PMC Article | 10/3/2020 |
| BDNF activates TrkB/PLCgamma1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis. | BDNF activates TrkB/PLCγ1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis.
Xu Y, Jiang WG, Wang HC, Martin T, Zeng YX, Zhang J, Qi YS. | 09/19/2020 |
| Frequent and Persistent PLCG1 Mutations in Sezary Cells Directly Enhance PLCgamma1 Activity and Stimulate NFkappaB, AP-1, and NFAT Signaling. | Frequent and Persistent PLCG1 Mutations in Sézary Cells Directly Enhance PLCγ1 Activity and Stimulate NFκB, AP-1, and NFAT Signaling.
Patel VM, Flanagan CE, Martins M, Jones CL, Butler RM, Woollard WJ, Bakr FS, Yoxall A, Begum N, Katan M, Whittaker SJ, Mitchell TJ. | 09/12/2020 |
| we describe the 2.5 A-resolution crystal structure of essentially full-length PLC-gamma1. The structure highlights a regulatory array exquisitely positioned to prevent membrane engagement of the catalytic core while simultaneously arranged to scaffold tyrosine kinases and additional regulatory proteins into a signaling nexus. | Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations.
Hajicek N, Keith NC, Siraliev-Perez E, Temple BR, Huang W, Zhang Q, Harden TK, Sondek J., Free PMC Article | 06/13/2020 |
| a combination of various biophysical methods has been employed to shed light on the atomistic interactions between PLCgamma1 and its known binding partners. Indeed, molecular modeling of PLCgamma1 with SLP76 peptide and with previously reported inhibitors | Investigation of Phospholipase Cγ1 Interaction with SLP76 Using Molecular Modeling Methods for Identifying Novel Inhibitors.
Tripathi N, Vetrivel I, Téletchéa S, Jean M, Legembre P, Laurent AD., Free PMC Article | 02/8/2020 |
| Induced miR-222 represses expression of ZBP1 and PLCgamma1 at the posttranscriptional level. | miR-222 represses expression of zipcode binding protein-1 and phospholipase C-γ1 in intestinal epithelial cells.
Jiang LP, Wang SR, Chung HK, Buddula S, Wang JY, Rao JN., Free PMC Article | 01/11/2020 |
| PLCgamma1 overexpression is a strong predictive surrogate marker of development of metastases in early Luminal-A and -B breast cancer patients, being able to discriminate patients with high and low risk of metastases. | PLC-gamma-1 phosphorylation status is prognostic of metastatic risk in patients with early-stage Luminal-A and -B breast cancer subtypes.
Lattanzio R, Iezzi M, Sala G, Tinari N, Falasca M, Alberti S, Buglioni S, Mottolese M, Perracchio L, Natali PG, Piantelli M., Free PMC Article | 01/4/2020 |
| PLCgamma1: Potential arbitrator of cancer progression. | PLCγ1: Potential arbitrator of cancer progression.
Jang HJ, Suh PG, Lee YJ, Shin KJ, Cocco L, Chae YC. | 09/14/2019 |
| novel insight into autophagy regulation by PLCgamma1 in colon cancer and hepatocellular carcinoma cells | Phosphoinositide-specific phospholipase Cγ1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Dai L, Chen X, Lu X, Wang F, Zhan Y, Song G, Hu T, Xia C, Zhang B., Free PMC Article | 07/20/2019 |
| In pancreatic cancer (PC) tissue samples expression of TSPAN1 was markedly increased compared to normal samples. siRNA knockdown of TSPAN1 in PC cell lines suppressed PC cell migration and invasion and downregulated MMP2 expression. Transfection with siRNA targeted to PLCgamma revealed that TSPAN1 siRNA suppressed PC cell migration and invasion, and MMP2 expression by blocking the translocation and phosphorylation of P... | TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ.
Zhang X, Shi G, Gao F, Liu P, Wang H, Tan X., Free PMC Article | 07/6/2019 |