| Hepatic progesterone receptor membrane component 1 attenuates ethanol-induced liver injury by reducing acetaldehyde production and oxidative stress. | Hepatic progesterone receptor membrane component 1 attenuates ethanol-induced liver injury by reducing acetaldehyde production and oxidative stress.
Jo SL, Baek IJ, Ko JW, Kwun HJ, Shin HJ, Hong EJ., Free PMC Article | 05/19/2023 |
| PGRMC1 Exerts Its Function of Anti-Influenza Virus in the Central Nervous System. | PGRMC1 Exerts Its Function of Anti-Influenza Virus in the Central Nervous System.
Huang K, Zhang Y, Gong W, Yang Y, Jiang L, Zhao L, Yang Y, Wei Y, Li C, He X, Sun X, Zou Z, Jin M., Free PMC Article | 02/5/2022 |
| Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer. | Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer.
Lee SR, Lee YH, Jo SL, Heo JH, Kim G, Lee GS, An BS, Baek IJ, Hong EJ., Free PMC Article | 01/29/2022 |
| Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism. | Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism.
McGuire MR, Mukhopadhyay D, Myers SL, Mosher EP, Brookheart RT, Kammers K, Sehgal A, Selen ES, Wolfgang MJ, Bumpus NN, Espenshade PJ., Free PMC Article | 12/18/2021 |
| PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones. | PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.
Chen YJ, Knupp J, Arunagiri A, Haataja L, Arvan P, Tsai B., Free PMC Article | 11/6/2021 |
| PGRMC1 in animal breast cancer tissue and blood is associated with increased tumor growth with norethisterone in contrast to progesterone and dydrogesterone: four-arm randomized placebo-controlled xenograft study. | PGRMC1 in animal breast cancer tissue and blood is associated with increased tumor growth with norethisterone in contrast to progesterone and dydrogesterone: four-arm randomized placebo-controlled xenograft study.
Cai G, Ruan X, Gu M, Zhao Y, Wang Y, Mueck AO. | 08/28/2021 |
| Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes. | Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.
Furuhata R, Kabe Y, Kanai A, Sugiura Y, Tsugawa H, Sugiyama E, Hirai M, Yamamoto T, Koike I, Yoshikawa N, Tanaka H, Koseki M, Nakae J, Matsumoto M, Nakamura M, Suematsu M., Free PMC Article | 06/19/2021 |
| Pgrmc1 may exert neuroprotective effects by blocking Tnf-alpha induction of downstream gene targets including gbp4, ifit3, and rtp4. In addition, Pgrmc1 may alter neuroinflammation by regulating neurosteroid synthesis, both directly through steroidogenic enzyme activation and indirectly through Nr4a1 regulation of steroidogenic enzyme expression. | Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells.
Intlekofer KA, Clements K, Woods H, Adams H, Suvorov A, Petersen SL., Free PMC Article | 02/15/2020 |
| Loss of Pgrmc1 increased mature SREBP-1 protein level, suggesting that induction of hepatic steatosis in Pgrmc1 KO mice might be triggered by de novo lipogenesis. Moreover, Pgrmc1 KO mice were also more vulnerable to early stage of non-alcoholic steatohepatitis, showing high levels of alanine aminotransferase, obesity-linked pro-inflammatory cytokines, and fibrosis markers. | Loss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis.
Lee SR, Kwon SW, Kaya P, Lee YH, Lee JG, Kim G, Lee GS, Baek IJ, Hong EJ., Free PMC Article | 11/23/2019 |
| survival of adult primordial ovarian follicles dependent in part on progesterone receptor membrane component 1 and 2 | PGRMC1/2 promotes luteal vascularization and maintains the primordial follicles of mice.
Peluso JJ, Liu X, Uliasz T, Pru CA, Kelp NC, Pru JK., Free PMC Article | 05/4/2019 |
| These results indicated that PGRMC1 mediated progesterone-induced suppression of oocyte meiotic progression and primordial folliculogenesis by decreasing intra-oocyte cAMP levels. | Progesterone Receptor Membrane Component 1 Mediates Progesterone-Induced Suppression of Oocyte Meiotic Prophase I and Primordial Folliculogenesis.
Guo M, Zhang C, Wang Y, Feng L, Wang Z, Niu W, Du X, Tang W, Li Y, Wang C, Chen Z., Free PMC Article | 05/12/2018 |
| The current studies establish the presence of PGRMC1 in retina and lay the foundation for analysis of its biological function. | Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina.
Shanmugam AK, Mysona BA, Wang J, Zhao J, Tawfik A, Sanders A, Markand S, Zorrilla E, Ganapathy V, Bollinger KE, Smith SB., Free PMC Article | 10/14/2017 |
| required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. | Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence.
Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK., Free PMC Article | 07/1/2017 |
| PGRMC1 expressed on the cell surface of beta cells was shown to interact with the activated GLP-1R to enhance the insulinotropic actions of GLP-1. | Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Zhang M, Robitaille M, Showalter AD, Huang X, Liu Y, Bhattacharjee A, Willard FS, Han J, Froese S, Wei L, Gaisano HY, Angers S, Sloop KW, Dai FF, Wheeler MB., Free PMC Article | 10/24/2015 |
| The aim of this study was to assess the expression, localization and hormonal regulation of two novel P(4) receptor candidates, P(4) receptor membrane component (PGRMC) 1 and PGRMC2, as well as the PGRMC1 partner Serpine 1 mRNA binding protein (SERBP1). | Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human.
Zhang L, Kanda Y, Roberts DJ, Ecker JL, Losel R, Wehling M, Peluso JJ, Pru JK. | 01/21/2010 |
| spectroscopic and biochemical characterization of binding to heme | Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p.
Ghosh K, Thompson AM, Goldbeck RA, Shi X, Whitman S, Oh E, Zhiwu Z, Vulpe C, Holman TR., Free PMC Article | 01/21/2010 |