| Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation. | Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation.
Xing M, Yang X, Jin S, Xu X. | 04/24/2024 |
| The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration. | The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration.
Zhou J, Wade SD, Graykowski D, Xiao MF, Zhao B, Giannini LAA, Hanson JE, van Swieten JC, Sheng M, Worley PF, Dejanovic B., Free PMC Article | 04/4/2023 |
| Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch. | Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch.
Kanehisa K, Koga K, Maejima S, Shiraishi Y, Asai K, Shiratori-Hayashi M, Xiao MF, Sakamoto H, Worley PF, Tsuda M., Free PMC Article | 05/14/2022 |
| Neuropathic pain-induced cognitive dysfunction and down-regulation of neuronal pentraxin 2 in the cortex and hippocampus. | Neuropathic pain-induced cognitive dysfunction and down-regulation of neuronal pentraxin 2 in the cortex and hippocampus.
Wang R, Man Y, Zhou M, Zhu Y, Wang L, Yang J., Free PMC Article | 12/25/2021 |
| Neuronal activity regulated pentraxin (narp) and GluA4 subunit of AMPA receptor may be targets for fluoxetine modulation. | Neuronal activity regulated pentraxin (narp) and GluA4 subunit of AMPA receptor may be targets for fluoxetine modulation.
Heinrich IA, Freitas AE, Wolin IAV, Nascimento APM, Walz R, Rodrigues ALS, Leal RB. | 11/13/2021 |
| Central nervous system-specific, tamoxifen-induced, and hippocampus-specific deletion demonstrate that the effects of Nptx2 deletion on anxiety-like behavior are hippocampus-specific and not developmentally related. In addition, mice with Nptx2 deletion exhibit decreased hippocampal cell proliferation and increased stress-induced neuronal activity. | NPTX2 is a key component in the regulation of anxiety.
Chang S, Bok P, Tsai CY, Sun CP, Liu H, Deussing JM, Huang GJ., Free PMC Article | 03/16/2019 |
| findings indicate that Narp contributes to the antidepressant action of Electroconvulsive Therapy and implicate the ability of Electroconvulsive Shock to induce dendritic arborization of differentiating granule cells as a relevant step in eliciting this response. | Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures.
Chang AD, Vaidya PV, Retzbach EP, Chung SJ, Kim U, Baselice K, Maynard K, Stepanian A, Staley M, Xiao L, Blouin A, Han S, Lee J, Worley PF, Tamashiro KL, Hempstead BL, Martinowich K, Ann Wilson M, Baraban JM, Reti IM., Free PMC Article | 02/9/2019 |
| PTX2 was identified PTX2 as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages. | Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.
Muczynski V, Aymé G, Regnault V, Vasse M, Borgel D, Legendre P, Bazaa A, Harel A, Loubière C, Lenting PJ, Denis CV, Christophe OD. | 08/12/2017 |
| Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials | Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, Karlsson RM, Cameron HA, Murata Y, Colonnese MT, Worley PF, McBain CJ., Free PMC Article | 05/23/2015 |
| Nptx2 contributes to the development of L-DOPA-induced dyskinesia. | Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia.
Charbonnier-Beaupel F, Malerbi M, Alcacer C, Tahiri K, Carpentier W, Wang C, During M, Xu D, Worley PF, Girault JA, Hervé D, Corvol JC., Free PMC Article | 03/21/2015 |
| These findings suggest that Narp, and perhaps other neuronal pentraxins, also regulate inflammation in the nervous system. | Selective expression of Narp in primary nociceptive neurons: role in microglia/macrophage activation following nerve injury.
Miskimon M, Han S, Lee JJ, Ringkamp M, Wilson MA, Petralia RS, Dong X, Worley PF, Baraban JM, Reti IM., Free PMC Article | 11/22/2014 |
| Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus. | Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.
Blouin AM, Lee JJ, Tao B, Smith DR, Johnson AW, Baraban JM, Reti IM., Free PMC Article | 06/28/2014 |
| the results of this study indicated that Narp released from mPFC neurons plays a key role in mediating synaptic changes underlying instrumental reinforcer devaluation. | Localized disruption of Narp in medial prefrontal cortex blocks reinforcer devaluation performance.
Johnson AW, Han S, Blouin AM, Saini J, Worley PF, During MJ, Holland PC, Baraban JM, Reti IM., Free PMC Article | 04/2/2011 |
| Narp prominently accumulated at excitatory synapses on parvalbumin-expressing interneurons, propose that Narp recruits AMPARs at excitatory synapses onto interneurons to rebalance network excitation/inhibition dynamics following increased circuit activity | Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons.
Chang MC, Park JM, Pelkey KA, Grabenstatter HL, Xu D, Linden DJ, Sutula TP, McBain CJ, Worley PF., Free PMC Article | 10/23/2010 |
| data indicate that the loss of NP1/2 disrupts several aspects of retinogeniculate development including the initial establishment of AMPAR transmission and the subsequent elimination of inappropriate circuit connections | Neuronal pentraxins mediate silent synapse conversion in the developing visual system.
Koch SM, Ullian EM., Free PMC Article | 05/31/2010 |
| findings indicate that Narp plays a selective role in extinction of morphine-induced place preference, possibly by its effects on AMPA receptor trafficking | Narp deletion blocks extinction of morphine place preference conditioning.
Crombag HS, Dickson M, Dinenna M, Johnson AW, Perin MS, Holland PC, Baraban JM, Reti IM., Free PMC Article | 01/21/2010 |
| these findings provide compelling evidence that Narp is secreted from vasopressin neurons in an activity-dependent fashion | Activity-dependent secretion of neuronal activity regulated pentraxin from vasopressin neurons into the systemic circulation.
Reti IM, Miskimon M, Dickson M, Petralia RS, Takamiya K, Bland R, Saini J, During MJ, Huganir RL, Baraban JM., Free PMC Article | 01/21/2010 |
| Neuronal pentraxin 1 and 2 are necessary for early synaptic refinements in mammalian retina and dorsal lateral geniculate nucleus. May exert their effects through mechanisms paralleling known role of short pentraxins outside the CNS. (Pentraxin 1 and 2) | Neuronal pentraxins mediate synaptic refinement in the developing visual system.
Bjartmar L, Huberman AD, Ullian EM, Rentería RC, Liu X, Xu W, Prezioso J, Susman MW, Stellwagen D, Stokes CC, Cho R, Worley P, Malenka RC, Ball S, Peachey NS, Copenhagen D, Chapman B, Nakamoto M, Barres BA, Perin MS., Free PMC Article | 01/21/2010 |