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    PLAU plasminogen activator, urokinase [ Homo sapiens (human) ]

    Gene ID: 5328, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Bioinformatics Analysis of the Expression and Prognostic Value of PLAU Gene in Wilms' Tumor.

    Bioinformatics Analysis of the Expression and Prognostic Value of PLAU Gene in Wilms' Tumor.
    Li D, Ding C, Huang F, Chang M, Lu Z, Li G, Li Y, Gao H, Sun F.

    10/7/2024
    PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration.

    PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration.
    Guo J, Wang H, Huang C, Lai C, Shang W, Luo S, Chen L.

    06/6/2024
    PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway.

    PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway.
    Cui X, Sun H, Liu X, Bai Y, Bai Y, Cui Y, Wang B, Zhang S, Li X.

    05/31/2024
    Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.

    Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.
    Cetinsoy O, Anyanwu I, Krishnanand H, Natarajan G, Ramachandran N, Thomas A, Brookes KJ.

    05/7/2024
    Inflammatory cytokines and oral lichen planus: a Mendelian randomization study.

    Inflammatory cytokines and oral lichen planus: a Mendelian randomization study.
    Chen X, Zhang S, Wu X, Lei Y, Lei B, Zhao Z., Free PMC Article

    03/25/2024
    Pan-cancer analysis of PLAU indicates its potential prognostic value and correlation with neutrophil infiltration in BLCA.

    Pan-cancer analysis of PLAU indicates its potential prognostic value and correlation with neutrophil infiltration in BLCA.
    Shi K, Zhou J, Li M, Yan W, Zhang J, Zhang X, Jiang L.

    01/5/2024
    Prognostic evaluation of oral squamous cell carcinoma based on pleiotrophin, urokinase plasminogen activator, and glycoprotein nonmetastatic melanoma protein B expression.

    Prognostic evaluation of oral squamous cell carcinoma based on pleiotrophin, urokinase plasminogen activator, and glycoprotein nonmetastatic melanoma protein B expression.
    Ma Y, Liu Y, Meng H., Free PMC Article

    11/18/2023
    PLAU contributes to the development of cholangiocarcinoma via activating NF-kappaB signaling pathway.

    PLAU contributes to the development of cholangiocarcinoma via activating NF-κB signaling pathway.
    Hu MD, Jia LH, Wang ML.

    07/17/2023
    Involvement of matrix metalloproteinase 1 and urokinase-type plasminogen activator in the PKCalpha-p38 MAPK pathway-mediated progression of human liver cancer cells.

    Involvement of matrix metalloproteinase 1 and urokinase-type plasminogen activator in the PKCα-p38 MAPK pathway-mediated progression of human liver cancer cells.
    Ye JC, Hsieh YS, Chen PN, Liu JY, Hsieh YH.

    06/16/2023
    Recent Advances in Targeting the Urokinase Plasminogen Activator with Nanotherapeutics.

    Recent Advances in Targeting the Urokinase Plasminogen Activator with Nanotherapeutics.
    Kumar AA, Vine KL, Ranson M.

    06/15/2023
    m6A Methyltransferase, WTAP, Promotes Cancer Progression in Laryngeal Squamous Cell Carcinoma by Regulating PLAU Stability.

    m6A Methyltransferase, WTAP, Promotes Cancer Progression in Laryngeal Squamous Cell Carcinoma by Regulating PLAU Stability.
    Liu F, Xia F, Wang C, Ren R, Zhang M, Gong J, Zhang Q.

    04/26/2023
    Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU).

    Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU).
    Hosen SMZ, Uddin MN, Xu Z, Buckley BJ, Perera C, Pang TCY, Mekapogu AR, Moni MA, Notta F, Gallinger S, Pirola R, Wilson J, Ranson M, Goldstein D, Apte M., Free PMC Article

    01/14/2023
    PLAU is associated with cell migration and invasion and is regulated by transcription factor YY1 in cervical cancer.

    PLAU is associated with cell migration and invasion and is regulated by transcription factor YY1 in cervical cancer.
    Gao Y, Ma X, Lu H, Xu P, Xu C., Free PMC Article

    12/31/2022
    METTL3 promotes colorectal cancer metastasis by stabilizing PLAU mRNA in an m6A-dependent manner.

    METTL3 promotes colorectal cancer metastasis by stabilizing PLAU mRNA in an m6A-dependent manner.
    Yu T, Liu J, Wang Y, Chen W, Liu Z, Zhu L, Zhu W.

    06/11/2022
    In situ hybridization for the assessment of urokinase plasminogen activator and plasminogen activator inhibitor type1 in formalinfixed paraffinembedded breast cancer specimens.

    In situ hybridization for the assessment of urokinase plasminogen activator and plasminogen activator inhibitor type‑1 in formalin‑fixed paraffin‑embedded breast cancer specimens.
    Boissière-Michot F, Mollevi C, Baecker V, Crapez E, Jacot W.

    05/7/2022
    Long non-coding RNA TRPM2-AS regulates microRNA miR-138-5p and PLAU (Plasminogen Activator, Urokinase) to promote the progression of gastric adenocarcinoma.

    Long non-coding RNA TRPM2-AS regulates microRNA miR-138-5p and PLAU (Plasminogen Activator, Urokinase) to promote the progression of gastric adenocarcinoma.
    Sun J, Zhou F, Xue J, Ji C, Qu Y, Pan Y., Free PMC Article

    02/19/2022
    Two Rare Variants in PLAU and BACE1 Genes-Do They Contribute to Semantic Dementia Clinical Phenotype?

    Two Rare Variants in PLAU and BACE1 Genes-Do They Contribute to Semantic Dementia Clinical Phenotype?
    Gaweda-Walerych K, Sitek EJ, Borczyk M, Berdyński M, Narożańska E, Brockhuis B, Korostyński M, Sławek J, Zekanowski C., Free PMC Article

    02/12/2022
    Roles of the Na(+)/H(+) Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion.

    Roles of the Na(+)/H(+) Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion.
    Li X, Buckley B, Stoletov K, Jing Y, Ranson M, Lewis JD, Kelso M, Fliegel L., Free PMC Article

    02/5/2022
    Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.

    Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
    Kang Y, Chen J, Li X, Luo M, Chen H, Cui B, Wang L, Lv D, Feng Y, Zhang P.

    01/15/2022
    The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation.

    The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation.
    Vorstandlechner V, Laggner M, Copic D, Klas K, Direder M, Chen Y, Golabi B, Haslik W, Radtke C, Tschachler E, Hötzenecker K, Ankersmit HJ, Mildner M., Free PMC Article

    12/4/2021
    uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils.

    uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils.
    Uhl B, A Mittmann L, Dominik J, Hennel R, Smiljanov B, Haring F, B Schaubächer J, Braun C, Padovan L, Pick R, Canis M, Schulz C, Mack M, Gutjahr E, Sinn P, Heil J, Steiger K, Kanse SM, Weichert W, Sperandio M, Lauber K, Krombach F, Reichel CA., Free PMC Article

    10/30/2021
    Overexpression of PSMC2 promotes the tumorigenesis and development of human breast cancer via regulating plasminogen activator urokinase (PLAU).

    Overexpression of PSMC2 promotes the tumorigenesis and development of human breast cancer via regulating plasminogen activator urokinase (PLAU).
    Wang Y, Zhu M, Li J, Xiong Y, Wang J, Jing H, Gu Y., Free PMC Article

    09/25/2021
    In Vitro Study of the Fibrinolytic Activity via Single Chain Urokinase-Type Plasminogen Activator and Molecular Docking of FGFC1.

    In Vitro Study of the Fibrinolytic Activity via Single Chain Urokinase-Type Plasminogen Activator and Molecular Docking of FGFC1.
    Gao C, Shen Q, Tang P, Cao Y, Lin H, Li B, Sun P, Bao B, Wu W., Free PMC Article

    05/15/2021
    Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors.

    Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors.
    Buckley BJ, Kumar A, Aboelela A, Bujaroski RS, Li X, Majed H, Fliegel L, Ranson M, Kelso MJ., Free PMC Article

    04/24/2021
    Studies on the changes of uPA system in a co-culture model of bone marrow stromal cells-leukemia cells.

    Studies on the changes of uPA system in a co-culture model of bone marrow stromal cells-leukemia cells.
    Zhou L, Guo H, Jia F, Chen X, Zhang X, Dong S, Zhao L., Free PMC Article

    04/17/2021
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